Reference

Effect of antioxidants on changes in the lipid content of rat liver lysosomes after thermal burn

Effect of antioxidants on changes in the lipid content of rat liver lysosomes after thermal burn. Burlakova, E. B.; Zaets, T. L.; Dubinskaya, N. I.; Molochkina, E. M.; Arkhipova, G. V. (Inst. Khim. Fiz., Moscow, USSR). Patol. Fiziol. Eksp. Ter., (5), 13-17 (Russian) 1984. CODEN: PAFEAY. ISSN: 0031-2991. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 18 I.p. treatment with dibunol [128-37-0], fenozan [90804-34-5], or vitamin E acetate [58-95-7] partially or completely normalized changes in liver lysosomal phospholipids induced in rats by skin burns.

Stability of doxorubicin-liposomes on storage: as an aqueous dispersion, frozen or freeze-dried

Stability of doxorubicin-liposomes on storage: as an aqueous dispersion, frozen or freeze-dried. Van Bommel, E. M. G.; Crommelin, D. J. A. (Subfac. Pharm., Univ. Utrecht, Utrecht 3511 GH, Neth.). Int. J. Pharm., 22(2-3), 299-310 (English) 1984. CODEN: IJPHDE. ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The shelf-life of doxorubicin (I) [23214-92-8]-contg. neg. charged liposomes was studied under various conditions. The following parameters were monitored: I-latency, stability against aggregation or fusion, and chem. stability or bilayer components and assocd. I. As an alternative for storing aq. dispersions, the liposomes were frozen and freeze-dried. Variables under investigation were: type of cryoprotectant [saccharides, poly(vinylpyrrolidone) [9003-39-8] and mannitol [69-65-8]], particle size (~0.1, 0.25 and 0.65 mm), and phys. state of the bilayer (gel- or fluid-like, inclusion of a-tocopherol acetate [58-95-7]). A comparison was made between the behavior of a bilayer interacting compd. (I) and a noninteracting compd. (carboxyfluorescein, CF). When stored as aq. dispersions extruded multilamellar structures (0.25 mm) showed lower I leakage rates than sonicated vesicles (0.1 mm). In the presence of various saccharides freezing and freeze-drying resulted in similar I latencies on thawing or rehydration; they provided adequate protection against aggregation or fusion. Other cryoprotectants failed. Latency of a bilayer-interacting drug like I, was hardly sensitive to variation of the bilayer structure; in contrast to this observation, latency of CF strongly depended on the bilayer compn. Under the exptl. conditions no effects of aging could be obsd. in terms of changing leakage profiles, aggregation behavior or chem. decompn. of I.