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Comparison between a new low dose urea capsule test and the conventional UBiT tablet test for the detection of Helicobacter pylori infection

All Rights Reserved. Several substances are used for example 58069-82-2 which is its cas registry number. Comparison between a new low dose urea capsule test and the conventional UBiT tablet test for the detection of Helicobacter pylori infection. Park, Seo-Jin; Park, Youn Hee; Lee, Sang In; Lee, Duk Chul; Yong, Dongeun; Kim, Jeong-Ho (Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, S. Korea). Daehan Jindan Geomsa Ui Haghoeji, 26(2), 81-85 (Korean) 2006 Korean Society for Laboratory Medicine. CODEN: DJGUAI. ISSN: 1598-6535. DOCUMENT TYPE: Journal CA Section: 9 (Biochemical Methods) Background: The urea breath test (UBT) is regarded as a highly reliable, noninvasive tool for diagnosing Helicobacter pylori infection. We compared a recently developed low-dose 38 mg 13C-urea capsule, which is able to eliminate oral urease effects and does not require positional changes during the test, with the conventionally used 100 mg 13C-urea tablet method. Methods: Thirty-nine volunteers were tested under informed consent with both 13C-UBT methods, Helifinder and UBiT-IR300, with a min. 2-wk washout period. The pre-ingestion and 20-min post-ingestion breath samples were analyzed with an isotope ratio mass spectrometer for Helifinder, and a nondispersive isotope-selective IR spectrophotometer for UBiT samples. Results: Helifinder method showed excellent agreement with UBiT among 19 pos. and 20 neg. cases (weighted kappa value, 1.0). Helifinder results (y) showed good agreement but with a proportional bias compared to UBiT results (x) by Passing and Bablok method (y=0.551x-0.255, r=0.74, P<0.0001). Conclusions: Since the low-dose 38 mg 13C-urea capsule (Helifinder) test, which is more convenient and economic, showed comparable results with the conventional UBiT method, it can be used as an alternative for the diagnosis of H. pylori infection. .

The 13C-urea breath test to detect Helicobacter pylori infection: A validated simple methodology with 50 mg 13C-urea

The 13C-urea breath test to detect Helicobacter pylori infection: A validated simple methodology with 50 mg 13C-urea. Liao, C.-C.; Lee, C.-L.; Chiang, T.-C.; Lee, S.-C.; Huang, S.-H.; Tu, T.-C.; Chen, T.-K.; Wu, C.There are some reagents like 58069-82-2 is used in this study.-H. (Division of Gastroenterology, Cathay General Hospital, Taipei 106, Taiwan). Alimentary Pharmacology and Therapeutics, 16(4), 787-792 (English) 2002 Blackwell Publishing Ltd. CODEN: APTHEN. ISSN: 0269-2813. DOCUMENT TYPE: Journal CA Section: 9 (Biochemical Methods) Background: Several modifications of the 13C-urea breath test have been published. For reasons of cost efficiency and practicability, the urea dose and measurement duration should be reduced while still maintaining excellent diagnostic accuracy. Aims: To establish a validated simple protocol for the urea breath test with 50 mg 13C-urea and to compare this protocol with the conventional urea breath test with 100 mg 13C-urea. Methods: Conventional urea breath test with 100 mg 13C-urea was performed on 152 dyspeptic patients. Full-cream cow's milk was used as the test meal. Breath tests were repeated using 50 mg 13C-urea and the breath samples were collected at baseline and at 10 (protocol t10), 15 (protocol t15) and 30 min (protocol t30). Helicobacter pylori status was assessed by rapid urease test, histol. and conventional urea breath test with 100 mg 13C-urea. Results: With protocol t15, the best combination of sensitivity (99.1%), specificity (97.3%) and accuracy (98.7%) was obtained with a cut-off of 2.5m. There was an extremely high correlation coeff. between the three protocols and conventional 13C-urea breath test (all P < 0.001). Conclusions: A urea breath test with 50 mg 13C-urea using a simple test meal and a 15-min sampling interval with a low cut-off seems to be cost-effective and convenient. In a well-standardized lab., this modification is not assocd. with any loss of diagnostic accuracy. .