Detail of "5845-67-0"

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Enhanced striatal 3H-spiroperidol binding induced by chronic haloperidol treatment inhibited by peptides administered during the withdrawal phase

Enhanced striatal 3H-spiroperidol binding induced by chronic haloperidol treatment inhibited by peptides administered during the withdrawal phase. Bhargava, Hemendra N. (Health Sci. Cent., Univ.Chemicals with cas numbers 2002-44-0 and 52-86-8 also play role. Illinois, Chicago, IL 60612, USA). Life Sci., 34(9), 873-9 (English) 1984. CODEN: LIFSAK. ISSN: 0024-3205. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Chronic intragastric administration of haloperidol [52-86-8] (1.5 mg/kg/day) for 21 days followed by a 3-day withdrawal period resulted in the development of enhanced locomotor activity response to apomorphine, and an increase in the no. of binding sites for 3H-spiroperidol in the striatal membranes of the rat brain. S.c. administration of Pro-Leu-Gly-NH2 [2002-44-0] or cyclo(Leu-Gly) [5845-67-0] in doses of 2 mg/kg/day given for 3-days after termination of haloperidol treatment inhibited the enhanced response to apomorphine, as well as the increases in the no. of [3H]spiroperidol binding sites in the striatum. If indeed, the supersensitivity of striatal dopamine receptors is one of the mechanisms in the development of tardive dyskinesia symptoms, the present results suggest that the above peptides may be helpful in ameliorating some of the symptoms of tardive dyskinesia induced by neuroleptic drugs. .

Effects of prolyl-leucyl-glycinamide and cyclo(leucyl-glycine) on the supersensitivity of dopamine receptors in brain induced by chronic administration of haloperidol to rats

Effects of prolyl-leucyl-glycinamide and cyclo(leucyl-glycine) on the supersensitivity of dopamine receptors in brain induced by chronic administration of haloperidol to rats. Bhargava, H. N. (Dep. Pharmacodyn., Univ. Illinois, Chicago, IL 60612, USA). Neuropharmacology, 23(4), 439-44 (English) 1984. CODEN: NEPHBW. ISSN: 0028-3908. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 1 The effects of Pro-Leu-Gly-NH2 (MIF) [2002-44-0], derived from the hypothalamus, and its enzymically stable analog, cyclo(Leu-Gly) [5845-67-0] on the supersensitivity of dopamine receptors in brain induced by chronic administration of haloperidol [52-86-8] to male Sprague-Dawley rats was detd. Oral administration of haloperidol (1.5 mg/kg/day) for 21 days induced supersensitivity of dopamine receptors as shown by enhanced locomotor activity in response to apomorphine, and an increase in the no. of binding sites for [3H]spiroperiodol in the striatum. The s.c. 2002-44-0 and 52-86-8 which are cas registry numbers of chemicals are mentioned. administration of MIF or cyclo(Leu-Gly) in doses of 2 mg/kg/day, given prior to the injection of haloperidol, inhibited both the enhanced response to apomorphine as well as the increase in the no. of binding sites for [3H]spiroperidol in the striatum. Chronic administration of either of the peptides did not modify the apomorphine-induced response or the binding of [3H]spiroperidol in the striatum. MIF and its long-acting analog can apparently prevent the development of both behavioral and biochem. supersensitivity of dopamine receptors in brain induced by neuroleptic drugs. These peptides may be useful in preventing the development of neuroleptic-induced tardive dyskinesia. .