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Detail of "58569-55-4"

  • CAS Number:
  • 58569-55-4
  • Name:
  • 1-5-Adrenorphin (human)(9CI)

  • Superlist Name:
  • Tyrosylglycyl-glycyl-phenylalanyl-methionine
  • Molecular Structure:
  • Formula:
  • C27H35 N5 O7 S
  • Molecular Weight:
  • 573.6611
  • Synonyms:
  • Adrenorphin(human), 6-de-L-arginine-7-de-L-arginine-8-de-L-valinamide-; 105: PN:US20030119021 SEQID: 92 unclaimed sequence; 106: PN: US20090048431 SEQID: 105claimed sequence; 10: PN: WO2008008805 SEQID: 10 unclaimed protein; 12: PN:US6258556 SEQID: 12 unclaimed sequence; 132: PN: WO2008125902 SEQID: 122unclaimed sequence; 153: PN: US20030176421 PAGE: 54-55 claimed protein; 16: PN:EP1498113 PAGE: 14 claimed protein; 16: PN: WO2009012472 SEQID: 16 unclaimedsequence; 18: PN: US6284459 SEQID: 33 unclaimed sequence; 18: PN: WO2006068768SEQID: 16 claimed sequence; 1: PN: US6265563 SEQID: 1 unclaimed sequence; 1:PN: WO03102015 SEQID: 1 claimed sequence; 1: PN: WO2004075843 PAGE: 5 unclaimedsequence; 1: PN: WO2005097158 SEQID: 1 unclaimed sequence; 210: PN: WO0069900SEQID: 882 unclaimed sequence; 211: PN: WO0069900 SEQID: 883 unclaimedsequence; 215: PN: WO0069900 SEQID: 887 unclaimed sequence; 25: PN:WO2005095443 SEQID: 25 claimed protein; 2: PN: US20040186059 PAGE: 2 unclaimedsequence; 2: PN: US20080045610 SEQID: 2 unclaimed sequence; 2: PN: WO2004073646TABLE: 3 unclaimed sequence; 2: PN: WO2008011381 SEQID: 58 unclaimed sequence;328: PN: WO2007106799 SEQID: 105 unclaimed sequence; 34: PN: US6319668 SEQID:33 unclaimed sequence; 3: PN: WO2008052043 SEQID: 2 claimed protein; 46: PN:US6017496 PAGE: 120 claimed protein; 4: PN: US20040209344 SEQID: 9 unclaimedsequence; 4: PN: US6395513 SEQID: 7 unclaimed sequence;5-L-Methionine-enkephalin; 5-Methionine enkephalin; 53: PN: US20090104234SEQID: 53 unclaimed protein; 5: PN: US20080039404 SEQID: 5 unclaimed sequence;6: PN: WO0130371 TABLE: 1 unclaimed sequence; 707: PN: US20090175821 SEQID: 882claimed protein; 7: PN: WO0130371 TABLE: 1 unclaimed sequence; 7: PN:WO2008106043 TABLE: 6 claimed protein; 9: PN: WO03061683 FIGURE: 1 unclaimedsequence; 9: PN: WO2004041151 SEQID: 9 unclaimed sequence; Enkephalin,methionine; Human b-endorphin(1-5); L-Methionine-enkephalin; Lupex; Met-enkephalin;Met5-enkephalin; Metenkefalin; Methionine enkephalin;
  • EINECS:
  • 261-335-8
  • Density:
  • 1.324 g/cm3
  • Boiling Point:
  • 1052.9 °C at 760 mmHg
  • Flash Point:
  • 590.6 °C
  • Solubility:
  • Soluble in water
  • Appearance:
  • White lyophilised solid
  • Safety:
  • 22-24/25 Details

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CAS No.58569-55-4 Tyrosylglycyl-glycyl-phenylalanyl-methionine

Met-Enkephaline Tyr-Gly-Gly-Phe-Met

Supplier:Alabiochem. Tech.Co., Ltd. [ China (Mainland)]

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CAS No.58569-55-4 Tyrosylglycyl-glycyl-phenylalanyl-methionine

H-TYR-GLY-GLY-PHE-MET-OH

Supplier:Labinova AB [ Senegal]

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Address:Labinova AB

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CAS No.58569-55-4 Tyrosylglycyl-glycyl-phenylalanyl-methionine

more information,pls contact with us!

Supplier:PEPTIDELAB [ United States]

610Integral
610

Tel:707 745 1500

Address:Primary SIC: Leather Goods, Not Elsewhere Classified, Primary NAICS: All Other Leather Good Manufacturing

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Reference

Neuronal actions of endorphins and enkephalins among brain regions: A comparative microiontophoretic study
Neuronal actions of endorphins and enkephalins among brain regions: A comparative microiontophoretic study. Nicoll, Roger A.; Siggins, George R.; Ling, Nicholas; Bloom, Floyd E.; Guillemin, Roger (Arthur Vining Davis Cent. Behav. Neurobiol., Salk Inst. Biol. Stud., La Jolla, Calif., USA). Proc. Natl. Acad. Sci. U. S. A., 74(6), 2584-8 (English) 1977. CODEN: PNASA6. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 1 .beta.-Endorphin [60617-12-1], a-endorphin [61512-76-3], 5-leucine enkephalin [58822-25-6], 5-methionine enkephalin [58569-55-4], and normorphine [466-97-7]were evaluated by microiontophoresis for their effects on neuronal activity in several regions of the rat brain. In cerebral cortex, brainstem, caudate nucleus, and thalamus, most responsive cells were inhibited by the peptides and by normorphine, whereas in the hippocampus all responsive cells were excited. Both inhibitory and excitatory responses were blocked by the narcotic antagonist naloxone. Occurrence of responsive cells encountered in a particular region was loosely correlated with d. of stereospecific opiate binding sites. The endorphins and enkephalins may represent a new class of central neurotransmitters; among other functions, these peptides may play a role in the regulation of behavior and the expression of psychopharmacol. agents such as the opiate alkaloids.
Enkephalin catabolism in vitro and in vivo
Enkephalin catabolism in vitro and in vivo. Meek, J. L.; Yang, H.-Y. T.; Costa, E. (Natl. Inst. Mental Health, St. Elizabeth's Hosp., Washington, D. C., USA). Neuropharmacology, 16(2), 151-4 (English) 1977. CODEN: NEPHBW. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Rat brain contained an aminopeptidase [9031-94-1] that metabolized methionine enkephalin [58569-55-4] and leucine enkephalin [58822-25-6], but not .beta.-endorphin [60617-12-1], and which released tyrosine from the enkephalins 20 times faster than glycine or leucine. The enzyme was inhibited by O-phenanthroline. Over 90% of an intraventricular dose of enkephalin was broken down in 1 min. Rapid metab. of enkephalins and related compds. should be prevented if assessment of their relative potency is required.
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