Welcome to LookChem.com Sign In|Join Free
  • or
Home > Pharmaceutical > 58581 > 

58581-89-8

Basic Information
CAS No.: 58581-89-8
Name: Azelastine
Article Data: 7
Molecular Structure:
Molecular Structure of 58581-89-8 (Azelastine)
Formula: C22H24ClN3O
Molecular Weight: 381.905
Synonyms: 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one;
EINECS: 253-720-4
Density: 1.25 g/cm3
Boiling Point: 533.9 °C at 760 mmHg
Flash Point: 276.7 °C
Appearance: white crystal powder
Hazard Symbols: N,T
Risk Codes: R50/53; R23/25
PSA: 38.13000
LogP: 4.23540
Synthetic route
53242-88-9

4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone

2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride

A

4-(p-Chlorbenzyl)-2-<2-(N-methylpyrrolidin-2-yl)-ethyl>-1(2H)-phthalazinon

B

58581-89-8

azelastine

Conditions
ConditionsYield
With sodium hydroxide at 70℃; for 1h; Yield given;
53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

2-Benzoyl-1-(hexahydro-1-methyl-1H-azepin-4-yl)hydrazin-hydrochlorid

58581-89-8

azelastine

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide 1.) reflux, 3 h, 2.) methanol, reflux, 2 h; Yield given. Multistep reaction;
1878-66-6

4-chlorophenylacetic Acid

58581-89-8

azelastine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: CH3COONa / 3 h / 245 - 250 °C
2: aq. NaOH / 2 h / Heating
3: 1.) 23percent aq. HCl, 2.) KOH / 1.) reflux, 3 h, 2.) methanol, reflux, 2 h
View Scheme
Multi-step reaction with 4 steps
1: CH3COONa / 3 h / 245 - 250 °C
2: aq. NaOH / 2 h / Heating
3: 90 percent / hydrazine sulfate, aq. NaOH / 2 h / Heating
4: aq. NaOH / 1 h / 70 °C
View Scheme
1859-33-2

1-methyl-1,2,3,5,6,7-hexahydroazepin-4-one

58581-89-8

azelastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2.) NaBH4 / 1.) CH3OH, room temp.
2: 1.) 23percent aq. HCl, 2.) KOH / 1.) reflux, 3 h, 2.) methanol, reflux, 2 h
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hydroxide / water / 1 h / 25 - 35 °C
1.2: 2 h / 0 - 10 °C
2.1: tetrahydrofuran / 1 h / 0 - 10 °C / Reflux
3.1: hydrogenchloride / 2 h / 20 °C / Reflux
3.2: 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hydroxide / water / 1 h / 25 - 35 °C
1.2: 2 h / 0 - 10 °C
2.1: tetrahydrofuran / 1 h / 0 - 10 °C / Reflux
3.1: hydrogenchloride / 2 h / 20 °C / Reflux
3.2: 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hydroxide / water / 1 h / 25 - 35 °C
1.2: 2 h / 0 - 10 °C
2.1: acetonitrile / 1 h / 0 - 10 °C / Reflux
3.1: hydrogenchloride / 2 h / 20 °C / Reflux
3.2: 2 h / Reflux
View Scheme
85-44-9

phthalic anhydride

3-<2-carboxy-phenyl>-pyridine-carboxylic acid-(2)

3-<2-carboxy-phenyl>-pyridine-carboxylic acid-(2)

58581-89-8

azelastine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: CH3COONa / 3 h / 245 - 250 °C
2: aq. NaOH / 2 h / Heating
3: 1.) 23percent aq. HCl, 2.) KOH / 1.) reflux, 3 h, 2.) methanol, reflux, 2 h
View Scheme
Multi-step reaction with 4 steps
1: CH3COONa / 3 h / 245 - 250 °C
2: aq. NaOH / 2 h / Heating
3: 90 percent / hydrazine sulfate, aq. NaOH / 2 h / Heating
4: aq. NaOH / 1 h / 70 °C
View Scheme
105279-16-1

(Z)-3-(4-chlorophenyl)methylidenephthalide

58581-89-8

azelastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. NaOH / 2 h / Heating
2: 1.) 23percent aq. HCl, 2.) KOH / 1.) reflux, 3 h, 2.) methanol, reflux, 2 h
View Scheme
Multi-step reaction with 3 steps
1: aq. NaOH / 2 h / Heating
2: 90 percent / hydrazine sulfate, aq. NaOH / 2 h / Heating
3: aq. NaOH / 1 h / 70 °C
View Scheme
53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

58581-89-8

azelastine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / hydrazine sulfate, aq. NaOH / 2 h / Heating
2: aq. NaOH / 1 h / 70 °C
View Scheme

1H-azepine, 4-hydrazinohexahydro-1-methyl, dihydrochloride

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

58581-89-8

azelastine

Conditions
ConditionsYield
Stage #1: 1H-azepine, 4-hydrazinohexahydro-1-methyl, dihydrochloride; 2‐(4-chlorophenylacetyl)benzoic acid With sodium hydroxide In methanol; water for 4h; Heating / reflux;
Stage #2: With hydrogenchloride In methanol; 2,8-dimethylnonan-5-one; water
79307-93-0

azelastine hydrochloride

58581-89-8

azelastine

Conditions
ConditionsYield
With sodium hydroxide In water pH=10; Inert atmosphere;

C14H23N3O(2+)*C4H2O4(2-)

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

58581-89-8

azelastine

Conditions
ConditionsYield
Stage #1: C14H23N3O(2+)*C4H2O4(2-) With hydrogenchloride at 20℃; for 2h; Reflux;
Stage #2: 2‐(4-chlorophenylacetyl)benzoic acid for 2h; Reflux;
8.1 g
  • Display:default sort

    New supplier

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 3.0-3.0

    As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

    Dayang Chem (Hangzhou) Co.,Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredi

  •  Dayang Chem (Hangzhou) Co.,Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-88938639

    Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China

       Inquiry Now

  • Factory Price API 99% Azelastine 58581-89-8 GMP Manufacturer

  • Casno:

    58581-89-8

    Factory Price API 99% Azelastine 58581-89-8 GMP Manufacturer

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.1-0.1

    1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

    Xi'an Xszo Chem Co. Ltd is a wholly-owned subsidiary of the SZO Chem Group. SZO Group is composed of Xi'an Xszo Chem Co. Ltd & Shaanxi SZO Tech Co., Ltd. SZO industry Group have mo

  •  Xi'an Xszo Chem Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-029-88698540

    Address:No.16,Jingqin Rd. JingWei Industrial park,Shaanxi,China,710200

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 5 Kiloliter

    FOB Price:  USD $ 1.2-5.0

    Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

    Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Fine chemicals, Active pharmaceutical ingredients(APIs), Veterinary, In

  •  Chemwill Asia Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:021-51086038

    Address:High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

    Our company engages in Electronic chemicals such as OLED,Photoresist chemical,Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

       Inquiry Now

  • Pharmaceutical Grade CAS 58581-89-8 with competitive price

  • Casno:

    58581-89-8

    Pharmaceutical Grade CAS 58581-89-8 with competitive price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 139.0-210.0

    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is (Wen Xi Pharma), including three subs

  •  Zhuozhou Wenxi import and Export Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

    Shandong Hanjiang Chemical Co., Ltd. is located in Qilu Petrochemical Industrial Park, Zibo City, Shandong Province, involving pesticide, medicine, chemical industry, coating, dy

  •  Shandong Hanjiang Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:18369939125

    Address:95A, Xingyuan East Road, Zhangdian District

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

    AFINE CHEMICALS LIMITED is specialized in the fine chemicals and pharmaceuticals and we have enjoyed great popularity in world markets. Since 2005, we have been rapidly growing to

  •  Afine Chemicals Limited

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-85134551

    Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

    J&H Chemical is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other

  •  Hangzhou J&H Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-87396432

    Address:No.200 Zhenhua Rd.Xihu Industrial Park, Hangzhou 310030, China

       Inquiry Now

  • Factory Supply Azelastine

  • Casno:

    58581-89-8

    Factory Supply Azelastine

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0

    The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

    Ality Chemical, established in 2007, is a comprehensive Chemical Production&Supply Group with Patent Technology as its core. Ality Chemical operates sales branches in Shanghai, Xia

  •  Ality Chemical Corporation

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:0513-87616220

    Address:Fine chemical industry park, Nantong,Jiangsu

       Inquiry Now

  • Azelastine hydrochloride

  • Casno:

    58581-89-8

    Azelastine hydrochloride

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

    Our company was funded in 2018. In order to adapt to the trend of world development, we established B2B e-commerce sector in Hangzhou. We supply raw material of chemicals, like API

  •  Hangzhou Fonlynn Health Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86 13291832373

    Address:Room 622, Building 11, Yifeng City, Nanyuan Street, Yuhang District

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0

    Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

    TaiChem was established in 2015 and registered in China medical city - Taizhou, Jiangsu Province. The company has about 1800 square meters of class A plant facility. TaiChem focuse

  •  TaiChem Taizhou Limited

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-0523-86810091

    Address:Changjiang Dadao 18

       Inquiry Now

  • AzelastineCAS NO.: 58581-89-8

  • Casno:

    58581-89-8

    AzelastineCAS NO.: 58581-89-8

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 3.0-3.0

    1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

    The company is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds,

  •  Henan Wentao Chemical Product Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-370-2722992

    Address:32 Room, 5th Floor, Building 11, No. 6 Yinxing Road, High-tech Industrial Development Zone, Zhengzhou City, Henan Province

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 1 Milligram

    FOB Price:  USD $ 0.0-0.0

    GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

  •  Xiamen Jenny Chemical Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86

    Address:xiameng

       Inquiry Now

  • Azelastine 58581-89-8

  • Casno:

    58581-89-8

    Azelastine 58581-89-8

    Min.Order: 10 Kilogram

    FOB Price:  USD $ 0.0-0.0

    CAS RN.: 58581-89-8 Molecular Weight: 382.9059 Molecular Formula:

    Wuhan Fortuna Chemical Co., Ltd, located in the predominant Wu Han City where is a traffic hinge of China, is a big integrative chemical enterprise being engaged in producing and

  •  Wuhan Fortuna Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-27-59207850

    Address:A2705,Dong Yi Shi Qu,129# XinHua Road,WuHan,China

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

    Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong

  •  Hangzhou Huarong Pharm Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-571-86758373

    Address:Room1707, 7Th Floor, Xin Chuanmei Industry Building , No.58 of Xintang Road, Jianggan District, Hangzhou, China.

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0

    Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

    Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, s

  •  Shandong Mopai Biotechnology Co., LTD

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-15965530500

    Address:shandong

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

    Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns

  •  Hunan chemfish Pharmaceutical co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:0731-85567275

    Address:No.10048, xiangjiang centry bulding ,kaifu district ,changsha city ,Hunan

       Inquiry Now

  • 58581-89-8  CAS NO.58581-89-8

  • Casno:

    58581-89-8

    58581-89-8 CAS NO.58581-89-8

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 7.0-8.0

    1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

    KAISA GROUP INC.is the enterprise which is specialize in manfacturing and exporting avariety of Chemical in China. We have the strong economic base and comprehensive technology.We

  •  KAISA GROUP INC

    United States  |  Contact Details

    Business Type:Trading Company

    Tel:15131197030

    Address:1312 17th Street Suite 1402 Denver CO 80202

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:shenzhen/shanghai

    Wuhan Vanz Pharm Inc. is a manufacturer&trading company.

  •  Hubei Vanz Pharm Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-27-84492310

    Address:FANHU INDUSTRY PARK

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

    GIHI CHEMICALS CO.,LIMITED, its former company is a small manufacturer who is specialized in the production of ester products which are used in the daily chemicals ,cosmetic produc

  •  GIHI CHEMICALS CO.,LIMITED

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:571-86217390

    Address:Huacai International Building,Sandun,Westlake District,Hangzhou 310030,Zhejiang,China

       Inquiry Now

  • 99% up by HPLC Azelastine 58581-89-8

  • Casno:

    58581-89-8

    99% up by HPLC Azelastine 58581-89-8

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API

    Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of ph

  •  Sinoway Industrial Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-592-583819

    Address:16/F,Huicheng Comm,Complex,No839 XiaHe Rd, Xiamen,China

       Inquiry Now

  • Acmec Azelastine 1g

  • Casno:

    58581-89-8

    Acmec Azelastine 1g

    Min.Order: 1 bottle

    FOB Price:  USD $ 0.0-0.0

    Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

  •  Shanghai Acmec Biochemical Technology Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86--

    Address:Room 1301, No. 1, Lane 1588, South Wangyuan Road, Nanqiao Town, Fengxian District, Shanghai

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

    Located in Zhengdong New District,?Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is a comprehensive high-tech modern enterprises integrating professional R&D, pro

  •  Henan Allgreen Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-0371-87507775

    Address:No 260 Dongming Road,Jinshui District

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

    Xiamen Aeco Chemical Industrial Co., Ltd(same as Aecochem Corp.) An ISO 9001:2015 Certified Company Your Partner in China, a Professional chemical raw material supplier, our

  •  Aecochem Corp.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-592 599 8717

    Address:No 611 Sishui Road,Huli

       Inquiry Now

  • Guanidine,N,N'''-1,3-propanediylbis-, hydrochloride (1:2)

  • Casno:

    58581-89-8

    Guanidine,N,N'''-1,3-propanediylbis-, hydrochloride (1:2)

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

    Antimex Chemical Limied, was founded in 2001, we are specializing in manufacturing & researching of Active pharmaceutical Ingredients,Veterinary pharm APIs,cosmetic ingredients,and

  •  Antimex Chemical Limied

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:0086-21-50563169

    Address:Room1027,No.Jinyu Road,Pudong

       Inquiry Now

  • Azelastine CAS No.58581-89-8

  • Casno:

    58581-89-8

    Azelastine CAS No.58581-89-8

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

    Guangdong Juda Chemical Industrial Co.,Limited is a company specializing in APIs,pharmaceutical intermediates, electronic chemicals, plant extracts,fine chemicals and cosmetics raw

  •  Guangdong Juda Chemical Industrial Co.,Limited

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 13510152023(whatsapp)

    Address:Guangzhou chemical city Tianhe District Guangzhou Guangdong China

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:intermediate

    HANGZHOU TIANYE CHEMICALS Co.LTD , Located in Eastern Science and Innovation Park Hangzhou . We are a high-tech enterprise specialized in technical research and development, produc

  •  HANGZHOU TIANYE CHEMICALS CO., LTD.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:0571-85083592

    Address:1208# HuaCe Building-B,Wuchanggang Road,XIHU District,Hangzhou City,Zhejiang Province ,China

       Inquiry Now

  • 58581-89-8

  • Casno:

    58581-89-8

    58581-89-8

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Supply top quality products with a reasonable price Application:api

    Changchun Artel Import and Export Trade Co., Ltd. is located in Changchun City, Jilin Province. It is a high-tech modern private enterprise specializing in the research, developme

  •  Changchun Artel lmport and Export trade company

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-0431-80543058

    Address:Dianshi Plazza,Chaoyang District

       Inquiry Now

  • Azelastine cas  58581-89-8

  • Casno:

    58581-89-8

    Azelastine cas 58581-89-8

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Azelastine cas 58581-89-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

    Welcome to Hangzhou Fandachem Co.,Ltd (www.FandaChem.com) Hangzhou Fandachem Co.,Ltd (Fandachem),an experienced and professional China-based Fine Chemical supplier. We supply the

  •  Hangzhou Fandachem Co.,Ltd

    China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86-571-28800458

    Address:Room 5010, No.9 YanAn Road,Hangzhou,Zhejiang,China

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10years Storage:Room temperature storage Pack

    Chongqing Ihlen Biotechnology Co., LTD., located in the first economic and technological development zone in Southwest China, is a young company mainly engaged in the research, dev

  •  Chongqing Ihlen Biotechlogy Co.,Ltd

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:13308389250

    Address:chongqing

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    *stable and better quality products*efficient and meticulous servicesAppearance:Powder Storage:Store in dry, cool and ventilated place Package:1kg/tin 5kg/tin 25kg/carton Application:Pharmaceutical raw materials, making injection powder oral agent Tr

    ASURE BIOCHEM Co., Ltd was established in March 2016. It is located in Hangzhou, a very beautiful city. It is a comprehensive chemical service provider with business scope coverin

  •  Asure Biochem CO.,LTD.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:15068760982

    Address:hangzhou

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.Appearanc

    BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-info

  •  BOC Sciences

    United States  |  Contact Details

    Business Type:Trading Company

    Tel:1-631-485-4226

    Address:Ramsey Road

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:100mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po

    Shanghai Yuanye Bio-Technology Co., Ltd. is a comprehensive enterprise of life science, specializing in the research, development and sales of biochemical reagents, analytical stan

  •  Shanghai Yuanye Bio-Technology Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-21-61845781

    Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    bulk?production Application:Pharmaceutical intermediates

    Introduction Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical manufacturing for overseas customers, in the field

  •  Chemsigma International Co.,Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-025-58748998

    Address:Rm.705, 15th Building,Rd.Xinke II

       Inquiry Now

  • Azelastine 58581-89-8

  • Casno:

    58581-89-8

    Azelastine 58581-89-8

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

    Shenzhen Foris Technology Co.LTD is located in Shenzhen ,Guangdong, is the leading supplier for electronic chemicals,APIs, pharmaceutical intermediates, fine chemicals which can be

  •  Shenzhen Foris Technology Co. LTD

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86 15889746615

    Address:BuildingA7, KingloryTongxin International Industry Park, Wanglei Avenue, Hi-tec District

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

    Zhejiang Jiuzhou Chemical Co.,Ltd is a market-oriented and innovation-driven biopharmaceutical company. The company is focusing on the R&D, manufacturing and sales of pharmaceutica

  •  ZHEJIANG JIUZHOU CHEM CO.,LTD

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 19334956669

    Address:Waisha Road,Jiaojiang

       Inquiry Now

  • Azelastine

  • Casno:

    58581-89-8

    Azelastine

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

  •  LEAP CHEM Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:0571-87317139

    Address:hangzhou

       Inquiry Now

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 58581-89-8

Chemistry

Chemical Name: Azelastine  
IUPAC Name: 4-[(4-Chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one 
CAS No.: 58581-89-8
Molecular Formula: C22H24ClN3O
Molecular Weight: 381.9 g/mol
Polar Surface Area: 35.91 Å2
Index of Refraction: 1.641
Molar Refractivity: 109.97 cm3
Molar Volume: 304.5 cm3
Surface Tension: 47.4 dyne/cm
Density: 1.25 g/cm3
Flash Point: 276.7 °C
Enthalpy of Vaporization: 81 kJ/mol
Boiling Point: 533.9 °C at 760 mmHg
Vapour Pressure: 1.77E-11 mmHg at 25°C
Following is the structure of Azelastine (CAS NO.58581-89-8):

            
The chemical synonymous of Azelastine (CAS NO.58581-89-8) are 1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin ; 4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1h-azepin-4-yl)-1-(2h)-phthalazinon ; AZELASTINE ; 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)- ; 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one ; CAS 790307-93-0 ; 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-y1)-1(2H)-phthalazinone .

Uses

 Azelastine (CAS NO.58581-89-8) is used for bronchial asthma, nasalallergy treatment.and used as a nasal spray (Astelin or Astepro)for hay fever and as eye drops (Optivar) for allergicconjunctivitis.

Toxicity Data With Reference

dog LD50 intravenous 13700ug/kg (13.7mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
dog LD50 oral 51300ug/kg (51.3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse LD50 intramuscular 59700ug/kg (59.7mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 intraperitoneal 42800ug/kg (42.8mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse LD50 intravenous 25400ug/kg (25.4mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 oral 124mg/kg (124mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
mouse LD50 subcutaneous 54200ug/kg (54.2mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat LD50 intramuscular 115mg/kg (115mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat LD50 intraperitoneal 43200ug/kg (43.2mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat LD50 intravenous 26900ug/kg (26.9mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat LD50 oral 310mg/kg (310mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
rat LD50 subcutaneous 59600ug/kg (59.6mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1184, 1981.
 

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Cl.

Specification

Side effects of Azelastine (CAS NO.58581-89-8) spray vary somewhat depending on the condition being treated. The most common side effects include bitter taste, headache, rhinitis, nose bleed, and somnolence. Adults being treated for vasomotor rhinitis may also experience dysesthesia and sinusitis.