Reference

Products of the reactions of 1-aroyl-2,2-dimethylhydrazines with propargyl and allyl bromides

Products of the reactions of 1-aroyl-2,2-dimethylhydrazines with propargyl and allyl bromides. Nakhmanovich, A. S.; Nizovtseva, T. V.; Karnaukhova, R. V.; Komarova, T. N.; Albanov, A. I.; Lopyrev, V. A. 1128-86-5 and 586-75-4 are cas registry numbers of chemicals which are used as reagents here. (Siberian Division, Favorskii Irkutsk Institute of Chemistry, Russian Academy of Sciences, Irkutsk, Russia). Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii), 73(4), 583-585 (English) 2003 MAIK Nauka/Interperiodica Publishing. CODEN: RJGCEK. ISSN: 1070-3632. DOCUMENT TYPE: Journal CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) 1-Aroyl-2,2-dimethylhydrazines underwent alkylation with propargyl and allyl bromides to form 1,1-dimethyl-1-(2-propyn-1-yl)- and 1,1-dimethyl-1-(2-propen-1-yl)-2-aroylhydrazinium bromides, resp. Treatment of these compds. with an NaOH soln. yielded ammonioaroylimides I (R1 = Ph, 4-BrC6H4; R2 = HCYC, H2C=CH; R1 = 2-ClC6H4; R2 = HCYC). .

Anti-tumor and antimicrobial compound, its microbiological preparation and its use as a medicament

Anti-tumor and antimicrobial compound, its microbiological preparation and its use as a medicament. Umezawa, Hamao; Takeuchi, Tomio; Hamada, Masa; Naganawa, Hiroshi; Takahashi, Yoshikazu; Iinuma, Hironobu; Sawa, Tsutomu; Tamamura, Tsuyoshi; Isshiki, Kunio (Microbial Chemistry Research Foundation, Japan). Eur. Pat. Appl. EP 205981 A2 30 Dec 1986, 16 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (European Patent Organization) CODEN: EPXXDW. CLASS: ICM: C12P001-06. ICS: C12N001-20. ICI: C12P001-06, C12R001-01. APPLICATION: EP 86-107339 30 May 1986. PRIORITY: JP 85-128580 12 Jun 1985. DOCUMENT TYPE: Patent CA Section: 16 (Fermentation and Bioindustrial Chemistry) Section cross-reference(s): 1, 10 Antibiotic MF730-N6, useful as an antitumor and antimicrobial agent, is produced by cultivation of Actinomycetes strain MF730-N6. Actinomycetes Was cultivated in medium contg. 69734-23-2 and 586-75-4 are also in the experiment. glucose, galactose, maltose, dextrin, bactosoytone, (NH4)2SO4 and antifoaming agent for 30 h at 27 °C with agitation and aeration. The antibiotic was isolated from the culture filtrate by chromatog. and purified by extn. with methanol to obtain 39 mg antibiotic from 24 L. Its MIC against Micrococcus albus was 0.39 mcg/mL. The antibiotic was also active against leukemia L1210 and Ehrlich's ascitic cancer in mice. .