Detail of "586-98-1"

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CAS Number:
586-98-1
Name:
2-(Hydroxymethyl)pyridine
Molecular Structure:
Formula:
C₆H₇NO
Molecular Weight:
109.14
Synonyms:
2-Pyridylcarbinol;5-21-02-00150 (Beilstein Handbook Reference);Piconolum [Latin];pyridin-2-ylmethanol;Pyridine-2-carbinol;Piconol [INN];2-Pyridylmethanol;2-Pyridinylmethanol;alpha-Picolyl alcohol;Pyridin-2-yl-methanol;Pyridine-2-methanol;2-Hydromethyl Pyridine;2-Pyridine methanol;
EINECS:
209-592-7
Density:
1.131 g/cm³
Melting Point:
5 °C
Boiling Point:
222.6 °C at 760 mmHg
Flash Point:
81.6 °C
Solubility:
miscible with water
Appearance:
Clear colorless to yellow or brown liquid
Hazard Symbols:
Xn, Xi
Risk Codes:
36/37/38-22
Safety:
26-36-37/39 Details

Substituted 2-Pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors: Substituted 2-Pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors. Ducharme, Yves; Friesen, Richard W.; Blouin, Marc; Cote, Bernard; Dube, Daniel; Ethier, Diane; Frenette, Richard; Laliberte, France; Mancini, Joseph A.; Masson, Paul; Styhler, Angela; Young, Robert N.; Girard, Yves (Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, QC H9R 4P8, Can.). Bioorganic & Medicinal Chemistry Letters, 13(11), 1923-1926 (English) 2003 Elsevier Science B.V. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 The synthesis and the phosphodiesterase-4 (PDE4) inhibitory activity of 2-pyridinemethanol derivs. are described. The evaluation of the structure-activity relation (SAR) in this series of novel PDE4 inhibitors led to the identification of compd. I which exhibits excellent in vitro activity, desirable pharmacokinetic parameters and good efficacy in animal models of bronchoconstriction.

Effect of vasoactive substances on glucose absorption and lactate production in isolated soleus muscles from healthy rats: Effect of vasoactive substances on glucose absorption and lactate production in isolated soleus muscles from healthy rats. Jungmann, E.; Schoeffling, K. (Zent. Inn. Med., Univ. Frankfurt, Frankfurt/Main, Ger.). Verh. Dtsch. Ges. Inn. Med., 82(1), 801-3 (German) 1976. CODEN: VDGIA2. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 2 In isolated rat soleus muscles, .beta.-pyridylcarbinol [586-98-1], nicotinic acid [59-67-6], and pentoxiphyllin [6493-05-6] increased glucose [50-99-7] uptake and lactate [50-21-5] prodn. In the presence of insulin [9004-10-8], these substances inhibited glucose uptake but had no effect on lactate release. ATP [56-65-5] (2 .times. 10-8 moles/mL) stimulated lactate release in an insulin-free medium without influencing glucose metab. At concns. 100-fold higher ATP stimulated glucose uptake and lactate release significantly. AMP [61-19-8] had no effect alone but combined with ATP blocked the ATP-induced lactate release. In the presence of insulin, however, ATP had no influence on glucose uptake but AMP + ATP stimulated glucose uptake but had no effect on lactate release. The significance of these studies to in vivo findings is discussed.