Detail of "5868-05-3"

CAS Number:
5868-05-3
Name:
3-Pyridinecarboxylicacid, 3,3'-[2,2-bis[[(3-pyridinylcarbonyl)oxy]methyl]-1,3-propanediyl] ester
Molecular Structure:
Formula:
C29H24 N4 O8
Molecular Weight:
556.57
Synonyms:
3-Pyridinecarboxylicacid, 2,2-bis[[(3-pyridinylcarbonyl)oxy]methyl]-1,3-propanediyl ester (9CI);Nicotinic acid, neopentanetetrayl ester (7CI,8CI); Pentaerythritol,tetranicotinate (8CI); 8-AL; Bufor; Niceritrol; Perycit; SK 1; SK 1(pharmaceutical)
Density:
1.347g/cm³
Boiling Point:
746.7°Cat760mmHg
Flash Point:
405.4°C
Safety:
Mildly toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x. See also ESTERS. Details

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Pharmacological studies on pentaerythritol tetranicotinate (SK-1): Pharmacological studies on pentaerythritol tetranicotinate (SK-1). V. General pharmacological actions. Hayashi, Motohide; Suzuki, Tsunemasa; Asano, Kyoichi; Uchiyama, Kaoru; Tanaka, Koji; Sugawara, Tsutomu; Asano, Osamu; Fujimura, Hajime (Res. Lab., Sanwakagaku Kenkyusho Co. Ltd., Kasugai, Japan). Oyo Yakuri, 14(5), 719-40 (Japanese) 1977. CODEN: OYYAA2. ISSN: 0369-8033. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) SK 1 (I) [5868-05-3] slightly induced the relaxation of isolated ileum, inhibited the hemolytic activity induced by heating, and had no affinity for erythrocytes, but had no effects on the central nervous system in mice and on the peripheral nervous system in rats. Apparently, the antihypertensive and anticholesteremic I has few side effects.

Pharmacological studies of pentaerythritol tetranicotinate (SK-1): Pharmacological studies of pentaerythritol tetranicotinate (SK-1). II. Effects on various experimental hyperlipemia of rats. Hayashi, Motohide; Suzuki, Tsunemasa; Asano, Kyoichi; Uchiyama, Kaoru; Tanaka, Koji; Sugawara, Tsutomu; Asano, Osamu; Fujimura, Hajime (Res. Lab., Sanwakagaku Kenkyusho Co. Ltd., Kasugai, Japan). Oyo Yakuri, 14(5), 679-87 (Japanese) 1977. CODEN: OYYAA2. ISSN: 0369-8033. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In the rat, SK 1 (I) [5868-05-3] decreased lipid levels in the liver and blood and increased lipoprotein lipase [9004-02-8] activity in hyperlipidemia. I showed therapeutic effects on spontaneous hypertensive rats.