Detail of "5874-97-5"

Reference

Investigation of the mutagenic activity of some drugs manufactured by Polfa using microbial genetic methods

Investigation of the mutagenic activity of some drugs manufactured by Polfa using microbial genetic methods. Starosciak, Bohdan; Pachecka, Jan; Dobrzanski, Wladyslaw T.; Bicz, Wlodzimierz (Zakl. Mikrobiol. Farm., Akad. Med., Warsaw 02-007, Pol.). Farm.Several substances with their cas registry numbers 738-70-5 and 59-66-5 may be metioned in this study. Pol., 39(7), 399-402 (Polish) 1983. CODEN: FAPOA4. ISSN: 0014-8261. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) No mutagenic activity of astmopent [5874-97-5], Baclofen [1134-47-0], binazine [3778-76-5], chirurcoll [25154-80-7], chlorpropamide [94-20-2], clonazepam [1622-61-3], craviten [55769-64-7], diuramide [59-66-5], furosemide [54-31-9], glafenine [3820-67-5], mirenil [2376-43-4], sadamine [437-74-1], and salbutamol [18559-94-9] was obsd. in the microbial tests used. Metronidazole [443-48-1], biseptol [8064-90-2], trimethoprim [738-70-5], and butapirazole [50-33-9] were mutagenic, the latter, however, only at high concns. .

Compatibility and stability of sympathomimetic bronchodilators in inhalant preparations

Compatibility and stability of sympathomimetic bronchodilators in inhalant preparations. Kawakatsu, Kazuo; Kuwata, Hiroshi (Dep. Pharm., Chest Dis. Res. Inst. Hosp., Kyoto 606, Japan). Byoin Yakugaku, 9(1), 45-52 (Japanese) 1983. CODEN: BYYADW. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The compatibility and stability of sympathomimetic bronchodilators clorprenaline-HCl (CP) [6933-90-0], isoproterenol-HCl (IP) [7683-59-2], orciprenaline sulfate (OP) [5874-97-5], salbutamol sulfate (SM) [51022-70-9] and trimetoquinol-HCl (TQ) [18559-59-6] with physiol. saline, Bisolvon Soln. or Alevaire were studied using high-pressure liq. chromatog. No visual change was obsd. when each soln.Several substances with their cas registry numbers 611-75-6 and 7683-59-2 may be metioned in this study. of the bronchodilator was mixed with physiol. saline or Bisolvon Soln. All of the bronchodilators maintained >96% of the initial amt. in the mixed soln. for 2 wk at room temp. When mixed with Alevaire, however, most of the bronchodialators except CP showed a decrease in content, developing a brown color, and TQ and IP showed a marked decrease. This color was due to oxidative degrdn. of bronchodilators in Alevaire. Thus, TQ, IP, OP and SM are incompatible with alk. solns. .