Detail of "58895-64-0"

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Inducing anorexia with nalbuphine or nalmetrene

Inducing anorexia with nalbuphine or nalmetrene. Smith, Dewey Howard, Jr. (du Pont de Nemours, E. I., and Co. , USA). Eur. Pat. Appl. EP 107855 A1 9 May 1984, 10 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: A61K031-485. APPLICATION: EP 83-110661 26 Oct 1983. PRIORITY: US 82-437324 28 Oct 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 17 Anorexia is induced in mammals by the oral administration of nalbuphine (I) [20594-83-6] or nalmetrene (II) [55096-26-9]. These compds. are neither stimulants nor depressants and do not cause central nervous system excitement, sedation, hypothermia or other side effects. Thus, tablets are prepd. each contg. II-HCl [58895-64-0] 40, lactose 230, microcryst. cellulose 23 and stearic acid 7 mg.

The permeation of nalmefene hydrochloride across different regions of ovine nasal mucosa

All Rights Reserved. The permeation of nalmefene hydrochloride across different regions of ovine nasal mucosa. Du, Gani; Gao, Yongliang; Nie, Shufang; Pan, Weisan (Department of Pharmacy, School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang 110016, Peop. Rep. China). Chemical & Pharmaceutical Bulletin, 54(12), 1722-1724 (English) 2006 Pharmaceutical Society of Japan. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The permeability of nalmefene hydrochloride (NH) across different regions of ovine nasal mucosa was investigated in vitro. Five different regions of ovine nasal mucosa (superior turbinate mucosa, middle turbinate mucosa, inferior turbinate mucosa, posterior septum mucosa, and anterior septum mucosa) were studied. The results showed that the permeability coeffs. of NH through different regions of nasal mucosa were different, and the suitable regions for the absorption of NH were the middle turbinate mucosa, the posterior septum mucosa and the superior turbinate. At the same time, the middle turbinate mucosa was the largest region among the five regions, thus it was the main absorption region for NH.In this experiment, several chemicals are used like 58895-64-0 The high uniformity of the middle turbinate mucosa also made it the most suitable model for the permeation of NH in vitro. .