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| CAS No.: | 58957-92-9 |
|---|---|
| Name: | Idarubicin |
| Article Data: | 8 |
| Molecular Structure: | |
|
|
|
| Formula: | C26H27NO9 |
| Molecular Weight: | 497.502 |
| Synonyms: | 5,12-Naphthacenedione,9-acetyl-7-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-,(7S-cis)-;1-Demethoxydaunorubicin;4-DMD;4-Demethoxydaunomycin;4-Demethoxydaunorubicin;Demethoxydaunorubicin; |
| EINECS: | 1806241-263-5 |
| Density: | 1.565 g/cm3 |
| Boiling Point: | 725.435 °C at 760 mmHg |
| Flash Point: | 392.529 °C |
| Hazard Symbols: |
 T+
|
| Risk Codes: | 60-61-28-40 |
| Safety: | 53-45 |
| Transport Information: | UN 2811 6.1/PG 2 |
| PSA: | 176.61000 |
| LogP: | 1.72060 |
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Chemistry
IUPAC Name: Idarubicin
The MF of Idarubicin (58957-92-9) is C26H28ClNO9.
The MW of Idarubicin (58957-92-9) is 533.95.
Synonyms of Idarubicin (58957-92-9): 11-Trihydroxy-(7s-cis)-alpha-l-lyxo-hexopyranosyl)oxy)- ; 4-Demethoxy-daunomyci ; 4-Demethoxy-daunorubicin ; 7,8,9,10-Tetrahydro-9-acetyl-7-((3-amino-2,3,6-trideoxy-12-naphthacenedione ; Nsc-256439;(7s-cis)-9-acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione
Product Categories: Active Pharmaceutical Ingredients
Index of Refraction: 1.705
Density: 1.56 g/ml
Flash Point: 392.5 °C
Boiling Point: 725.4 °C
Storage temp: 2-8 °C
Form: solid
Uses
Idarubicin (58957-92-9) is used for acute myelogenous leukemia, inhibit tumor growth, anti-breast cancer.
Toxicity Data With Reference
| 1. | mmo-sat 2 µg/plate | ENMUDM Environmental Mutagenesis. 7 (1985),129. | ||
| 2. | dns-rat:lvr 2 mg/L | CNREA8 Cancer Research. 44 (1984),5599. | ||
| 3. | dnd-mus:fbr 1800 nmol/L | CNREA8 Cancer Research. 37 (1977),4523. | ||
| 4. | dnd-mam:lym 200 nmol/L | BBRCA9 Biochemical and Biophysical Research Communications. 69 (1976),744. | ||
| 5. | orl-mus LD50:16 mg/kg | CTRRDO Cancer Treatment Reports. 61 (1977),893. | ||
| 6. | ipr-mus LD50:3 mg/kg | CNREA8 Cancer Research. 48 (1988),926. | ||
| 7. | ivn-mus LD50:4 mg/kg | CTRRDO Cancer Treatment Reports. 61 (1977),893. |
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also DAUNOMYCIN.
Safety information of Idarubicin (58957-92-9):
Hazard Codes .gif){kind=small}
T+
Risk Statements
60 May impair fertility
61 May cause harm to the unborn child
28 Very Toxic if swallowed
40 Limited evidence of a carcinogenic effect
Safety Statements
53 Avoid exposure - obtain special instruction before use
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
RTECS HB7877000