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59-02-9

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  • MSDS Download
  • CAS Number:
  • 59-02-9
  • Name:
  • 2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,[2R-[2R*(4R*,8R*)]]-

  • Superlist Name:
  • d-a-Tocopherol
  • Molecular Structure:
  • Formula:
  • C29H50O2
  • Molecular Weight:
  • 430.79
  • Deleted CAS:
  • 364-49-8
  • Synonyms:
  • (+)-a-Tocopherol;(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol;(2R,4'R,8'R)-a-Tocopherol;(R,R,R)-a-Tocopherol;(all-R)-a-Tocopherol;5,7,8-Trimethyltocol;Covitol F 1000;Covitol F 1300;Covitol IK 00069;Denamone;Endo E;Eprolin;Eprolin S;Epsilan;Esorb;Etavit;NSC 20812;NatAlc;Natur-E micelle;Phytogermin;Spavit E;Syntopherol;Tenox GT 1;Tokopharm;Vascuals;Verrol;Viteolin;alpha-Tocopherol;a-Vitamin E;Vitamin E;
  • EINECS:
  • 200-412-2
  • Density:
  • 0.93 g/cm3
  • Melting Point:
  • 2.5-3.5 °C
  • Boiling Point:
  • 485.856 °C at 760 mmHg
  • Flash Point:
  • 210.229 °C
  • Solubility:
  • insoluble in water
  • Appearance:
  • light yellow liquid
  • Hazard Symbols:
  • IrritantXi
  • Risk Codes:
  • 36/37/38
  • Safety:
  • 23-24/25-37/39-26 Details

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CAS No.59-02-9 d-a-Tocopherol

Min. Order:1 Kilogram USD:80-120 /Kilogram

Assay:67%-96%(1000IU-1430IU) Appearance:Clear,amber, viscous oil Package:Aluminum Drum(5kg, 20kg), stainless steel drum(50kg,185kg) Storage:Store in dry places and keep away from strong direct light and heat. Application:Pharm, Food, Nutrition, Health Products Others:              Specifications 1.USP/EP/BP/FCC/CP 2.GMP/DMF/KOSHER/HALAL/HACCP...More

  • Supplier:HANGZHOU TOYOND BIOTECH CO., LTD[ China (Mainland)]
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  • HANGZHOU TOYOND BIOTECH CO., LTD is a professional supplier of Vitamins, Nutrition, Food additives, Feed additives and APIs. Our plant had 20 years experience in this field, which proved by GMP system, ISO system and HACCP system....More
  • Contact:Mr. James Claudio Chai  Tel:+86-571-86965177 Fax:+86-571-86961633
  • Address:No. 189, Fengqi East Road, Hangzhou, China
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CAS No.59-02-9 d-a-Tocopherol

Appearance:pale-yellow to yellowish-brown, clear viscous, oily liquid

DetailDesc:  

Tel:86-571-56926320

Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG

Introduction:Xinchang Yueding Chemical Co., Ltd. was established in 2006. As an integrated company, we are specializing in Feed Additives, Food Additives, pharmaceuticals and other chemicals. Main products are as...more

Min. Order:20Kilogram

Supplier:Xinchang Yueding Chemical Co., Ltd.

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CAS No.59-02-9 d-a-TocopherolCompetitive Product

Assay:99%

Appearance:clear yellow liquid

Package:25kg plastic pail

DetailDesc:  

Tel:+86-310-8892458;8892278

Address:Quzhou Industrial Estate, Handan, Hebei, China

Introduction:Welcome to Hebei Yaguang (Hebei Yaguang Fine Chemical Co., Ltd). We are the first manufacturer for 5,5-dimethyl hydantoin and its ramifications in China. We own two facilities covering 40,000 square ...more

Min. Order:100Kilogram USD:1-100 /Kilogram

Supplier:Hebei Yaguang Fine Chemical Co.,Ltd

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Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

Storage:10

Assay:98%

Package:drum

Tel:+86-571-88938639

Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China

Introduction:Hangzhou Dayangchem Co.,Ltd dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredient(s); Nutritional products; C...more

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CAS No.59-02-9 d-a-Tocopherol

Storage:store in dry and clean environment

Assay:99%

Appearance:white powder

Package:1 kg in aluminum bag

DetailDesc:  

Tel:+86-13938578871

Address:No.39 Zhengtong Road,Zhengzhou,Henan

Introduction:Zhengzhou Xingren Chemical Products Co., Ltd. was a chemical enterprise affiliated to Japan-owned Xingren Group. After reorganization, our company now has become a specialized manufacturing company w...more

Min. Order:1Kilogram

Supplier:Zhengzhou Xingren Chemical Products Co.,Ltd.

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Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

Storage:keep in a clean and dry place

Assay:99%

Appearance:withe powder

Package:1kg/bag;25kgs/drum

DetailDesc: Product name:Tocopheryl Specification: 99%

Tel:86-29-88232053

Address:No.18 Keji Road, High-tech Zone, Xi’an.

Introduction:Yan'an Changtai Pharmaceutical Co., Ltd. (China) is an international pharmaceutical enterprise integrating the production, purchase, sales, import and export of herbal/plant extracts, chemicals produ...more

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CAS No.59-02-9 d-a-Tocopherol

Storage:store in a cool, dry place and keep away from direct strong light,44 years shelf time

Appearance:fine powder

Package:296 kg/vacuum aluminum foil bag, 25 kgs/fiber drum or as customer's request

DetailDesc:PeterYang

Tel:+86-29-85733402

Address:No.108 ,west sector,south er huan,xi'an,china

Introduction:Shaanxi Top Pharm Chemical Co., Ltd. has been primarily engaged in the research, development, and marketing of various photochemical products since 1999. We take full advantages of natural pharmaceut...more

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Business Type:Lab/Research institutions

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CAS No.59-02-9 d-a-Tocopherol

Assay:Min.50% of vitamin E

Appearance:White or off-white free-flowing powder

Package:25kg/drum

DetailDesc:1.Product name: Vitamin E / 2.Other name: VE,D-alpha-Tocopherol / 3.MF: C29H50O2 / / 4.Grade Standard: Food Grade, Medicine Grade / 5.Storage:Kept in a lig

Tel:86-024-66692426

Address:NO.4 North Yunfeng Street,Tiexi.District,Shenyang

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:  

Tel:86-29-85352872

Address:SAN XING YUAN,ZHU QUE STREET,YAN TA ZONE, XI AN 710065

Introduction:Y&L BIOTECH CO.,LTD Mainly engaes in the development,production and sales of natural herb extract, Amino-acids, API and chemical intermediated, Chemical synthesis materials. We are one of the key N...more

Supplier:Y&L Biotech Co., Ltd.

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CAS No.59-02-9 d-a-Tocopherol

Tel:+86-311-89643238

Address:No.19 pingan North street,Qiaodong District,Shijiazhuang,P.R. China

Introduction: Shijiazhuang Sute Trade Co., Ltd., located in the Norther China, Shijiazhuang,is a big integrative chemical enterprise being engaged in supplying pharmaceut...more

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CAS No.59-02-9 d-a-Tocopherol

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Address:Hang Xing Road

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CAS No.59-02-9 d-a-Tocopherol

Storage:stored in cool and air place

Assay:>50%

Appearance:White or off-white free-flowing powder

Package:25KG/CARTON

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Address:ZHONGSHAN ROAD SHIJIAZHUANG

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:  

Tel:0013777223024,13738483102

Address:ningbo

Introduction:NINGBO HONGDA CHEM INTERNATIONAL CO., LTD is specialized in the export of Chinese pharmaceutical raw materials, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc. We also...more

Supplier:huang shijie

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:Vitamin E

Tel:+86-571-85617789

Address:Rm 409 Wenxin Building No.207, Wen'er Road, Hangzhou, China

Introduction: Hangzhou Amazingchem Co., Ltd. is subject to an Imp.& Exp. enterprise. Hangzhou Amazingchem Co., Ltd. is a professional company engagine in researching, deve...more

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:VITAMIN E 50% feed grade

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Address:50 Sang Yuan Road,Jinan,China

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CAS No.59-02-9 d-a-Tocopherol

Tel:+86-512-5636 2180

Address:Zhangjiagang Free Trade Zone

Introduction:  Synochem Ingredients Co., Ltd., is a leading Vitamin K3 and L-Carnitine supplier in China, which specilizes in Vitamins, Amino Acids, food/feed additves, n...more

Supplier:Synochem Ingredients Corp., Ltd.

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CAS No.59-02-9 d-a-Tocopherol

MSDS/COA Download

Storage:In a cool dry place. Protect from heat or moisture.

Assay:depends on specifications

Appearance:Pale yellow or reddish oil or white powder

Package:25kg/paper drum OR 50/200/950kg/stainess steal drum

DetailDesc:            Mixed   Tocopherols Powder

Tel:+86-551-2827005

Address:Jinrong Mansion, No. 384 Jinzhai Rd

Introduction:We focus on human health care for more than 10 years. We only offer top quality products. We are dedicated to providing full line of Nutritional additives, Cosmetic ingredients, Botanical extra...more

Min. Order:100Kilogram USD:1-300 /Kilogram

Supplier:Hongkong KING PLUS INTERNATIONAL CO., LIMITED

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

Storage:in the dark place without light, heat and air.

Assay:67.1%, 73.82%, 80.54%, 87.25%

Appearance:light yellow to brownish red

Package:stainless steel drum

DetailDesc: Appearance: D-alpha tocopherol is a light yellow to brownis

Tel:86-527-18800613040

Address:No. 38,Cixi Road,Shuyang Economic Development Zone, Jiangsu, China

Min. Order:50Kilogram USD:90-130 /Kilogram

Supplier:Jiangsu xixin vitamin

[ China (Mainland)]

Business Type:Manufacturers

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ISOHALALKOSHER

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CAS No.59-02-9 d-a-Tocopherol

Storage:Store in cool & dry place,Keep away from strong light and heat.

Assay:T3 92%

Appearance:Light yellow Oily

Package:PE double sealed plastic bags outsourcing aluminum foil, transport the outer packing for paper barrel

DetailDesc:About Tocopherol & TocotrienolThe main molecular structure of tocopherol (TP, T1) and tocotrienol (TT ,T3) are the same, and their differences are expressed by their different side chain, which the

Tel:+86-29-88324612-8058

Address:80# JinYe 1ST Road, Xi'an National Hi-tech Industrial Development Zone, China.

Introduction:Xi’an HaoTian Bio-Engineering Technology Co., Ltd. was established on Feb. 14th, 2003. Since the company has been established, our company exerted its technical privileges sufficiently to extra...more

Min. Order:1Kilogram USD:803-806 /Kilogram

Supplier:Xi'an HaoTian Bio-engineering Co., Ltd

[ China (Mainland)]

Business Type:Manufacturers

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CAS No.59-02-9 d-a-Tocopherol

Storage:Store in a well-closed container away from moisture and direct sunlight

Assay:1000IU/ 1300IU

Appearance:pale-yellow to yellowish-brown, clear viscous oily liquid

Package:20KG/STEEL DRUM,50KG/STEEL DRUM

DetailDesc: Introduction:D-alpha-Tocopherol is a kind of pale-yellow to yellowish-brown, clear viscous oily liquid, nearly odorless, 

Tel:+86-025-84650384

Address:#38 Hongwu Road, Nanjing Nan Road, Nanjing China

Introduction:Dedicated to supply for human health, Kangcare is specialized in developing, manufacturing and marketing natural nutraceutical ingredients for the Dietary supplements, Food, Cosmetic and Pharmaceutic...more

Min. Order:20Kilogram

Supplier:Kangcare Bioindustry Co., Ltd.

[ China (Mainland)]

Business Type:Manufacturers

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CAS No.59-02-9 d-a-Tocopherol

Storage:keep in dark place

Assay:1000IU/1100IU

Appearance:A light yellow-brownish red liquid

Package:50KG/DRUM;200KG/DRUM

DetailDesc:PRODUCT NAME: NATRUAL VITAMIN E Other Name: Non GMO d alpha Tocopherol Oil / Powder Molecular Formula: C29H50O2 Specification: PHARM/FOOD/FEED/USP/BP/EP/FCC NON-GMO/IP/KOSHER/HALAL/HACCP/IS

Tel:+86-021-57585157

Address:No.1000,Road JiuDu,Songjiang District,ShangHai,China

Introduction:Shanghai HOPE Industry Co.,LTD We are a professional supplier of Vitamins, Amino Acid and its Derivatives, Plant extracts, Pharmaceutical intermediates, Pharmaceutical raw materials, Fine chemic...more

Min. Order:200Kilogram

Supplier:ShangHai HOPE Industry Co.,Ltd.

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

Storage:It should be protected from light and oxygen. Keep the container tightly closed. Once opened, use contents quickly.

Assay:950IU~1200IU

Appearance:pale-yellow to yellowish-brown, clear viscous, oily liquid; nearly odorless. Darkens slowly in air and on exposure to light.

Package:(20/50/190kg)/drum

DetailDesc:1000IU d-α-tocopherol is a pale-yellow to yellowish-brown, clear viscous oily liquid, nearly odorless, darkens slowly in air and on exposure to light. It is derived from natural sources, i.e. from ed

Tel:+86-23-67683887

Address:B1-1205, Xinke International Plaza, 68 Jinyu Avenue, Northern New District, Chongqing, 401122, China

Introduction:Our company specializes in high quality Human Nutrition, Animal Nutrition, Cosmetic ingredient and Pharmaceutical Intermediate. Such as Beta-Carotene, Carotenoids, Vitamin A, Vitamin C, Vitamin E, Sy...more

Min. Order:50Kilogram

Supplier:Nutrachem Limited

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

Assay:99.5%

DetailDesc:  Vitamin E, VE, Natural Vitamin E, Gamma tocopherol, Alpha tocopherol           

Tel:86-551-62878590

Address:6-1607, Wanda Plaza,130 Wuhu Road, Hefei, 230002, China.,Anhui,China (Mainland)

Introduction:Q-Full specializes in Food and Feed and Cosmetic Nutrition products and Cosmetic materials from 2002. Q-Full plants have advanced product line and excellent administration system with ISO , HAPPC...more

Min. Order:100Kilogram

Supplier:SHANGHAI Q-FULL INTERNATIONAL CO.,LTD.

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:D-alpha Tocopherol Oil/Natural Vitamin E/Tocopherol PRODUCT NAME: NATRUAL VITAMIN E Other Name: Non GMO Natural Mixed Tocopherol / d-alpha Tocopherol Molecular Formula: C29H50O2 CAS Num

Tel:+86-21-54265599-8092

Address:26F,Xingyuan Technology Building,No. 418, Guiping Road, Shanghai

Introduction:Uniserchem was founded in shanghai, China in 1995. Since then we have strived to meet the requirements of our customers through an understanding of their individual needs, sourcing a wide range ...more

Min. Order:50Kilogram USD:20-100 /Kilogram

Supplier:shanghai uniser chemical co.,ltd

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

Storage:24 months

Package:20kg , 50kg , 200kg, 950kg

DetailDesc:ITEM STANDARD Appearance Brownish red oil Acidity ≤1.0ml Potency,IU/g 1000IU ~ 1300IU

Tel:+86-551-62878570 EXT8006

Address:6-1607, Wanda Plaza,130 Wuhu Road, Hefei, 230002, China.

Introduction:Shanghai Q-Full International Co., Ltd. (HONGKONG Q-FULL Industrial Limited) specializes in Food and Feed and Cosmetic Nutrition products and Cosmetic materials from 2002. Q-Full plants have advan...more

Supplier:HONGKONG Q-FULL INDUSTIRAL LIMITED

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Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:1, CAS:59-02-9, Name:VItamin E OIL 2, White or colorless crystal 3, Specification: USP32/98% 4, Packing: 200 kg/drum 5, 10MT per month

Tel:+86-571-28195962

Address:Hangzhou zhongshan road

Introduction:  Zhejiang Medicines and Health Products Import &Export Co., Ltd (herein after called ZMC) is a subsidiary of Zhejiang International Business Group Co., ...more

Min. Order:1Kilogram USD:29-32 /Kilogram

Supplier:zmc

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Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

Assay:20-50%

Appearance:Yellow viscous liquid

Package:packed in 180KG new iron drums, total 98 drums per 20' container

Tel:+86-571-61103963

Address:Yuda Building, Tiyuchang Road, Xiacheng District

Introduction:Zhejiang Zhengtai Industrial Co.,Ltd is a leading China producer&supplier of Organic Chemicals,Inorganic chemicals,pharmaceutical intermediates.With a wide experience in exporting chemicals, We have ...more

Supplier:Zhejiang Zhengtai Industrial Co.,Ltd

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Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

Assay:96-102%

DetailDesc:Product Name:Vitamin E Specification:assay:96-102%;Come from famous international brand Appearance and Properties: brown red or light yellow oil liquid,with a mild special flavor easily soluble i

Tel:(020)61736388

Address:No.A1, Sanlian Industrial Zone, Licheng Street, Zengcheng City , Guangzhou, China

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Supplier:Kevin Food Co.,Ltd

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Business Type:

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:we can supply high quality of vitamin e,kindly contact us when you have this need.thank you.

Tel:86-551-3502023 13856968278

Address:D13 building, Swan Lake, Dongliu Road, Hefei, Anhui, China

Introduction:   ...more

Min. Order:1Kilogram USD:1-1000 /Kilogram

Supplier:Anhui Leafchem Co., Ltd.

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:Vitamin C: 1. Purity 99.9% 2. White Crystalline powder 3. BP2010/E300/USP32/FCC7/EP7 4. ISO/GMP/Halal/Kosher Appearance: White granular powder, melting at about 190degrees centigrade. Graduall

Tel:+86-571-85113358

Address:5/F, No.178 Tian Mu Shan Road.

Introduction:   ...more

Min. Order:1000Kilogram

Supplier:Hangzhou Cntech Company

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:Name Vitamin E Synonyms D-alpha-Tocopherol; (2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol Molecular Structure Molecular Formula C29H5

Tel:86-510-86106900

Address:No.205,zhencheng Road, HI-TECT District, Wuxi, Jiangsu,China

Introduction:         Wuxi Mizat Chemical Technology Co., Ltd.is a professional enterprise for the manufacture and development, sales and ou...more

Supplier:Wuxi Mizat Chemical Technology Co., Ltd

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:Mixed tocopherol Oil 50%~90% (Natural tocopherol): Natural Vitamin E (Tocopherol) is derived from vegetable oil, as nature's fat-soluble antioxidant constitutes: It exists as a mixture of 4 homol

Tel:+86-29-86030149 86030234

Address:JingHe Industrial Park, Xi'an Economic & Technology Development Zone, Xi'an China

Introduction:Shaanxi Tianwei Biological Products Co.Ltd., a high-tech private enterprise engaged in the biochemistry, which was established in 1998 and located in Jinghe Industrial Park, Xi'an Economic and Techno...more

Supplier:Shaanxi Tianwei Biological Products Co.Ltd.

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:Mixed tocopherol 30% powder.It is a water-dispersible fine powder which is light tan in color with a bland odor taste. It contains nature mixed tocopherols which are obtained from edible vegetable oi

Tel:+86-029-89192175

Address:D-10908. Oak Block, No. 36 FengHui South Rd. Xi'an High-tech Development Zone. Xi'an 710075, P.R. China

Supplier:Xi'an Healthful Biotechnology Co.,Ltd

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:Gallic acid CAS NO.149-91-7 Myricetin CAS NO.529-44-2 Shikimic Acid CAS NO.138-59-0 Natural vitamin E (mixed tocopherol) CAS NO.59-02-9 Phytosterol CAS NO.83-46-5 N,N’-Dicyclohexy

Tel:13566347633

Address:21 Jiangxia Str.,Ningbo,315000 China

Introduction:Ningbo Dekang Biochem Co., Ltd main products : Plant Extracts and Raw Material,Natural herbs, Herbal Supplements,Spices,Vitamins , Botanicals,Multi-herb formulas Extract,powder, granules, minced, c...more

Supplier:Sinochem Ningbo Ltd.

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:D-alpha-Tocopherol Nature Vitamin E cas 59-02-9 d-a-tocopherol Vitamin E oil nature density: 0.95 melting point :3.2 degree specs : 50% ,70% ,80% , 90% packing size :180kgs/ c

Tel:86-717-6305888

Address:wenshayayuan18D

Supplier:Yichang Trade INC

[ China (Mainland)]

Business Type:Trading Company

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc: Natural Vitamin E (Tocopherol) is derived from soybean oil or rapeseed oil,as nature’s fat-soluble antioxidant constitutes:Alpha-tocopherol, Beta-tocopherol, Gamma-tocopherol, Delta-tocopherol. Beta

Tel:+86-27-87641416 87668853

Address:11/F Hongsheng building, Guangba road, Hongshan district, Wuhan,China.

Introduction:Wuhan Kaidi Fine Chemical Industrial Co., LTD is a high-tech enterprise engaged in the fine chemistry, biochemistry and water-treatment. The shares of its parent company, Wuhan Kaidi Electric Power C...more

Supplier:Wuhan Kaidi Fine Chemical Industrial Co., LTD

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CAS No.59-02-9 d-a-Tocopherol

DetailDesc:D-alpha-Tocopherol 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, (2R)- Covitol F 1000 Etamican Endo E Vita E Mixed tocopherols alpha-Tokoferol c

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Protective effect of coenzyme Q on adriamycin toxicity in beating heart cells
Protective effect of coenzyme Q on adriamycin toxicity in beating heart cells. Kishi, Takeo; Takahashi, Kyoko; Mayumi, Tadanori; Hama, Takao (Fac. Pharm. Sci., Kobe-Gakuin Univ., Kobe 673, Japan). Biomed. Clin. Aspects Coenzyme Q, 4, 181-94 (English) 1984. CODEN: BCAQDA. ISSN: 0167-8450. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 18 Inhibition by adriamycin (ADM) [23214-92-8] of the beating of cultured mouse heart cells was dose- and time-dependent. A 50% cessation of beating was obsd. with doses of 430-520 mM ADM for 0.5 h, 70-100 mM ADM for 4 h, or 3.5 mM ADM for 36 h. When cultured heart cells were incubated with 3.5 mM [3H]ADM, the isotope was found to have been fully incorporated into the cells by 24 h, but the beating cell count continued to decrease gradually from 80% at 24 h to 10% at 72 h. The lipid peroxide level in the cells in the presence of 3.5 mM ADM had not significantly increased by 24 h, but had increased to about 1.5 times the control level, by 48 h. Addn. of 120 mM a-tocopherol (Toc) [59-02-9] in advance of the ADM treatment, depressed lipid peroxidn. by 86%, but did not protect beating from ADM toxicity. In contrast, 120 mM coenzyme Q10 (CoQ10) [303-98-0] reduced the lipid peroxidn. only by 33%, but increased the beating count at 48 h from 42% to 68%. Further, CoQ10 did not affect uptake of ADM by the cells. ADM inhibition of O uptake by the cells, was strongly correlated with percent cessation of beating, in the dosage range of 70-520 mM ADM. The ATP content of the cells in the presence of 3.5 mM ADM decreased following decrease in the beating cell count. Apparently stimulation of lipid peroxidn. by ADM does not initiate beat inhibition of the cultured heart cells; the protective effect of CoQ10 seems to be based on biochem. actions other than redn. of lipid peroxidn. and inhibition of ADM uptake.
Anthralin compositions for treating psoriasis
Anthralin compositions for treating psoriasis. Stiefel, W. K.; Nicolai, D. W. (Stiefel Laboratories, Inc., USA). Belg. BE 899975 A1 15 Oct 1984, 17 pp. (French). (Belgium). CODEN: BEXXAL. ICI: A61. APPLICATION: BE 21-186 20 Jun 1984. PRIORITY: US 83-506414 21 Jun 1983; US 84-585515 2 Mar 1984. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Topical compns. for psoriasis treatment consist of anthralin (I) [1143-38-0] 0.05-5%, a lipid-sol. antioxidant 0.02-2%, an emulsion contg. water and a liq. hydrocarbon in a ratio of 5:1 and 1 or more water-sol. substances such as carboxylic acids and a bifunctional sesquestering agent 0.02-2%. A topical compn. was prepd. by using the following ingredients: an oily phase contained mineral oil 6.0, paraffin 2.3, petrolatum 2.3, Al stearate 0.7, glyceryl oleate 1.5, anthralin 0.22, ascorbyl palmitate [137-66-6] 0.02, 2-octyldodecanol 3.0 and salicylic acid [69-72-7] 0.4%; an aq. phase contained water 68.82, citric acid [77-92-9] 0.9, di-Na EDTA [139-33-3] 0.06, sorbitol 13.5, Me p-hydroxybenzoate 0.15, Pr p-hydroxybenzoate 0.10 and a-tocopherol [59-02-9] 0.03%. The 2 phases were homogenized to form the emulsion.
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