Detail of "59-05-2"

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CAS Number:
59-05-2
Name:
L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
Superlist Name:
Methotrexate
Molecular Structure:
Formula:
C₂₀H₂₂N₈O₅
Molecular Weight:
454.44 .
Synonyms:
Glutamicacid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-(8CI);(+)-Amethopterin;Amethopterin;Amethopterine;Antifolan;CL 14377;EMT 25299;Emtexate;Emthexate PF;L-Amethopterin;L-Methotrexate;Ledertrexate;Metatrexan;Mexate;N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(+)-glutamicacid;NSC 740;R 9985;Rheumatrex;Trexall;
EINECS:
200-413-8
Density:
1.536 g/cm³
Melting Point:
195 °C
Solubility:
insoluble in water
Appearance:
yellow crystalline powder
Hazard Symbols:
T
Risk Codes:
61-25-36/38-46
Safety:
53-26-36/37-45-36/37/39 Details
Transport Information:
UN 2811 6.1/PG 3

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Reference

Pharmacokinetics of methotrexate and 7-hydroxymethotrexate in rabbits after intravenous administration: Pharmacokinetics of methotrexate and 7-hydroxymethotrexate in rabbits after intravenous administration. Chen, Mei Ling; Chiou, Win L. (Coll. Pharm., Univ. Illinois, Chicago, IL 60612, USA). J. Pharmacokinet. Biopharm., 11(5), 499-513 (English) 1983. CODEN: JPBPBJ. ISSN: 0090-466X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The pharmacokinetics of methotrexate (MTX) [59-05-2] and 7-hydroxymethotrexate (7-OH-MTX) [5939-37-7], a major metabolite, were investigated in rabbits after i.v. bolus injection and infusion. Arterial sampling (from the carotid artery) was used in all the studies, since peculiar and significant arteriovenous differences in the plasma concn. of MTX and 7-OH-MTX were found following bolus administration of the drug. The disposition kinetics of MTX appeared polyexponential, with a small terminal phase having a half-life of 10.2-27.5 h. Extensive formation of 7-OH-MTX occurred at the 2 dose levels used (15 and 50 mg/kg).In this article, certain chemicals are used. Some of their cas registry numbers are 5939-37-7 and 59-05-2 Nonlinear disposition of MTX was reflected in several aspects of data anal. A disproportionate increase with dose in the area under the plasma concn.-time curve was obsd. An increase in dose not only reduced the mean total body clearance (7.49 vs. 4.26 mL/min/kg) and renal clearance (4.89 vs. 2.76 mL/min/kg), but also prolonged the mean residence time (26.2 vs. 43.3 min). The steady-state vol. of distribution of MTX was estd. to be 0.16-0.25 L/kg. More than 90% of the dose was excreted as MTX and 7-OH-MTX within 8 h after dosing. Renal clearances decreased with the increasing plasma levels, suggesting active tubular secretion as one of the excretion mechanisms. A similar pattern for renal clearance of 7-OH-MTX was obtained. Infusion studies of 7-OH-MTX revealed that this metabolite had a longer residence time and a larger stead-state vol. of distribution than MTX, which is in accordance with its physicochem. properties. Essentially complete doses of 7-OH-MTX could be recovered in the rabbit urine. .

Enzyme-amplified determination of methotrexate with a pCO2 membrane electrode: Enzyme-amplified determination of methotrexate with a pCO2 membrane electrode. Seegopaul, Purneshwar; Rechnitz, G. A. (Dep. Chem., Univ. Delaware, Newark, DE 19711, USA). Anal. Chem., 56(4), 852-4 (English) 1984. CODEN: ANCHAM. ISSN: 0003-2700. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) An enzyme cycling amplification procedure (potentiometric) in conjunction with a pCO2 membrane electrode is described for the detn. of methotrexate [59-05-2] in microgram quantities. The method is based on the inhibition of dihydrofolate reductase [9002-03-3] which couples with 6-phosphogluconic dehydrogenase to recycle the NADP+/NADPH redox system. Inhibition of the reductase by methotrexate decreases the extent of cycling which is then directly related to the drug concn. 9002-03-3 and 59-05-2 which are cas registry numbers of substances are two of reagents here. The method gave good anal. precision and accuracy with a detection limit of 1.5 mg methotrexate/L. .

Detail of "59-05-2"

L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-

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Reference