CAS No.59-40-5,Sulfaquinoxaline Suppliers

Products Categories

Pharmaceutical (97)
Organic Chemicals (16)
Others (16)
Reagent (5)
Materials (4)
Plant Extract (3)
(1)
Food Additives (1)
Synthetic Flavours & Fragrances (1)

Basic Information

Molecular Structure:
CAS No.:	59-40-5
Name:	Sulfaquinoxaline
Article Data:	7

Formula:	C₁₄H₁₂N₄O₂S
Molecular Weight:	300.341
Synonyms:	Sulfanilamide,N1-2-quinoxalinyl- (6CI,7CI,8CI);2-(p-Sulfanilamido)quinoxaline;2-Sulfanilamidobenzopyrazine;2-p-Aminobenzenesulfonamidoquinoxaline;2-p-Aminobenzenesulphonamidoquinoxaline;Avicocid;Compound 3-120;Italquina;Kokozigal;N1-(2-Quinoxalinyl)sulfanilamide;NSC 41805;SQ 40;SQX;Sulfa-Q 20;Sulfabenzpyrazine;Sulfaline;Sulfaquinoxaline;Sulphaquinoxaline;Sulquin;Ursokoxaline;
EINECS:	200-423-2
Density:	1.491 g/cm³
Melting Point:	247-248 °C
Boiling Point:	551.1 °C at 760 mmHg
Flash Point:	287.1 °C
Solubility:	Insoluble in water, ethanol and acetone, soluble in alkaline solution
Appearance:	light yellow crystalline powder
Hazard Symbols:	Xn
Risk Codes:	22-42/43
Safety:	22-36/37-45
PSA:	106.35000
LogP:	3.74780

Synthetic route

: 63-74-1
sulfanilamide

: 79-11-8
chloroacetic acid

: 95-54-5
1,2-diamino-benzene

: 59-40-5
sulphaquinoxaline

Conditions

Conditions	Yield
Stage #1: chloroacetic acid; 1,2-diamino-benzene With N'-methyl-N-heptylimidazolium hydroxide salt at 100℃; for 2h; Stage #2: sulfanilamide With trichlorophosphate at 100℃; for 3h; Concentration; Temperature;	93%

...Expand

: 6632-67-3
N-[4-(quinoxalin-2-ylsulfamoyl)phenyl]acetamide

: 59-40-5
sulphaquinoxaline

Conditions

Conditions	Yield
With sodium hydroxide In water for 2h; Heating;	91.2%
With hydrogenchloride; ethanol; water

: 1448-87-9
2-chloroquinoxaline

: 63-74-1
sulfanilamide

: 59-40-5
sulphaquinoxaline

: 5424-05-5
quinoxalin-2-ylamine

: 59-40-5
sulphaquinoxaline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 31.6 percent / pyridine / 25 °C 2: 91.2 percent / NaOH / H2O / 2 h / Heating View Scheme
Multi-step reaction with 2 steps 1: pyridine 2: water; ethanol; HCl View Scheme

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

4-acetoxy-N1-acetyl-o-phenylenediamine: 4-acetoxy-N1-acetyl-o-phenylenediamine

: 59-40-5
sulphaquinoxaline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 31.6 percent / pyridine / 25 °C 2: 91.2 percent / NaOH / H2O / 2 h / Heating View Scheme

: 85414-82-0
2-aminoquinoxaline-3-carboxylic acid

: 59-40-5
sulphaquinoxaline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: nitrobenzene 2: pyridine 3: water; ethanol; HCl View Scheme

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

: 59-40-5
sulphaquinoxaline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine 2: water; ethanol; HCl View Scheme

: 490-59-5
alloxazine

: 59-40-5
sulphaquinoxaline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water; H2SO4 2: pyridine 3: water; ethanol; HCl View Scheme
Multi-step reaction with 4 steps 1: water; NH3 / 175 °C 2: nitrobenzene 3: pyridine 4: water; ethanol; HCl View Scheme

: 59-40-5
sulphaquinoxaline

: 439-14-5
diazepam

: 4-([4-{7-chloro-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl}phenyl]diazenyl)-N-(quinoxalin-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
Stage #1: sulphaquinoxaline With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.0833333h; Green chemistry; Stage #2: diazepam With sodium acetate In ethanol; water Green chemistry;	90%

: 463-71-8
thiophosgene

: 59-40-5
sulphaquinoxaline

: 681235-15-4
4-isothiocyanato-N-(quinoxalin-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
In water for 1h;	86%

Raw Materials

121-60-8

490-59-5

63-74-1

Total:118 Page 1 of 4 1 2 3 4 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 59-40-5

Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The IUPAC name of Sulfaquinoxaline is 4-amino-N-quinoxalin-2-ylbenzenesulfonamide. With the CAS registry number 59-40-5, it is also named as 2-(p-Sulfanilamido)quinoxaline. The product's categories are Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds. It is light yellow crystalline powder which is insoluble in water, ethanol and acetone, soluble in alkaline solution. When heated to decomposition it emits very toxic fumes of NO_x and SO_x. Additioanlly, this chemical should be sealed in the container.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.63; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.57; (4)ACD/LogD (pH 7.4): -0.48; (5)ACD/BCF (pH 5.5): 1.52; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 45.01; (8)ACD/KOC (pH 7.4): 4.07; (9)#H bond acceptors: 6; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.733; (13)Molar Refractivity: 80.7 cm³; (14)Molar Volume: 201.3 cm³; (15)Polarizability: 31.99×10^-24 cm³; (16)Surface Tension: 83.7 dyne/cm; (17)Enthalpy of Vaporization: 83.13 kJ/mol; (18)Vapour Pressure: 3.42E-12 mmHg at 25°C; (19)Rotatable Bond Count: 3; (20)Tautomer Count: 2; (21)Exact Mass: 300.068096; (22)MonoIsotopic Mass: 300.068096; (23)Topological Polar Surface Area: 106; (24)Heavy Atom Count: 21; (25)Complexity: 442.

Preparation of Sulfaquinoxaline: Using o-phenylenediamine as raw material. Firstly, o-phenylenediamine reacts with sodium cyanide, formaldehyde in acidic media to obtain N-cyanomethyl-o-phenylenediamine. Secondly, the cyclization of N-cyanomethyl-o-phenylenediamine and potassium hydroxide to generate 2-amino-3,4-dihydro-yl. Thirdly, using hydrogen peroxide to dehydrogenize in the presence of ferrous chloride to get 2-amino-quinoxaline. Finally, after condensation and hydrolysis with acetylsulfanilyl chloride
sulfonamides, we can get the product.

Uses of Sulfaquinoxaline: It is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis. It is also used as an animal-specific broad-spectrum antimicrobial agent, which is more toxic to mammals.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. And it also may cause sensitization by inhalation and skin contact, so people should not breathe dust. If you want to contact this product, you must wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
1. SMILES:O=S(=O)(c1ccc(N)cc1)Nc2nc3ccccc3nc2
2. InChI:InChI=1/C14H12N4O2S/c15-10-5-7-11(8-6-10)21(19,20)18-14-9-16-12-3-1-2-4-13(12)17-14/h1-9H,15H2,(H,17,18)
3. InChIKey:NHZLNPMOSADWGC-UHFFFAOYAA

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	15gm/kg (15000mg/kg)		"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A370, Pg. 1983,
rat	LD50	oral	1370mg/kg (1370mg/kg)		Personal Communication from W.M. Mahlburg, Hopkins Agricultural Chemical Co., P.O. Box 7532, Madison, WI 53707, Nov. 16, 1982Vol. 16NOV1982,