CAS No.59-61-0,Benzenemethanol,3,4-dichloro-a-[[(1-methylethyl)amino]methyl]- Suppliers

CAS Number:
59-61-0
Name:
Benzenemethanol,3,4-dichloro-a-[[(1-methylethyl)amino]methyl]-
Formula:
C11H15 Cl2 N O
Molecular Structure:
Synonyms:
Benzylalcohol, 3,4-dichloro-a-[(isopropylamino)methyl]- (8CI); (?à)-3',5'-Dichloroisoproterenol; (?à)-Dichlorisoproterenol; (?à)-Dichloroisoproterenol;1-(3,4-Dichlorophenyl)-1-hydroxy-2-isopropylaminoethane;1-(3',4'-Dichlorophenyl)-2-isopropylaminoethanol; 20522; 3,4-Dichloro-a-[(isopropylamino)methyl]benzylalcohol; 3,4-Dichloroisopropylnoradrenaline; 3,4-Dichloroisoproterenol; DCI;DCI (pharmaceutical); Dichlorisoprenaline; Dichlorisoproterenol;Dichloroisoprenaline; Dichloroisopropylarterenol;Dichloroisopropylnoradrenaline; Dichloroisoproterenol; Isoproterenol,dichloro-; L 20522
Molecular Weight:
248.17
Density:
1.221g/cm³
Boiling Point:
361°Cat760mmHg
Flash Point:
172.1°C
Safety:
Poison by ingestion and intravenous routes. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.Details

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Qualitative relationship between molecular structure and pharmacological action: A hypothesis on the nature of the b-adrenergic receptor: Qualitative relationship between molecular structure and pharmacological action: A hypothesis on the nature of the b-adrenergic receptor. Martin, Miguel L.; Hernandez, J. A. (Fac. Med., Univ. Auton. Barcelona, Bellaterra, Spain). Afinidad, 35(354), 187-92 (Spanish) 1978. CODEN: AFINAE. ISSN: 0001-9704. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Electrostatic mol. potentials were calcd., using Mulliken's approxn., for isoprenaline [7683-59-2], DCI [59-61-0], INPEA [5704-60-9], o-doberol [67834-82-6], m-doberol [20917-89-9], and p-doberol [34380-06-8]. The results are discussed in relation to the applicability of mol.In this study，7683-59-2 is also used. potentials in analyzing structure-activity relations and in elucidating the electrostatic structure of adrenergic receptors. .

Pharmacological analysis of b-adrenoceptor-mediated agonism in the guinea pig, isolated, right atrium: Pharmacological analysis of b-adrenoceptor-mediated agonism in the guinea pig, isolated, right atrium. Black, J. W.; Gerskowitch, V. P.; Leff, P.; Shankley, N. P. (Wellcome Res. Lab., Beckenham/Kent BR3 3BS, UK). Br. J. Pharmacol., 84(3), 779-85 (English) 1985. CODEN: BJPCBM. ISSN: 0007-1188. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The recently developed, operational model of pharmacol. agonism defines the efficacy of agonists by t = [Ro]/KE, where [Ro] is the total functional concn. of receptors and KE is the concn. of agonist-occupied receptors for half-maximal effect. Theor., variations in [Ro] and KE affect t and, in turn effect/concn. (E/[A]) curve profiles similarly. Expts. on the b-adrenoceptor-mediated chronotropic responses of the guinea pig isolated right atrial prepn. were used to investigate the consequences of exptl. [Ro] and KE variation. The irreversible b-receptor antagonist bromoacetylalprenolol menthane produced displacements of isoprenaline [7683-59-2] and dichloroisoprenaline [59-61-0] E/[A] curves consistent with [Ro] redn. Cholrea toxin produced displacements consistent with decreases in KE. The operational model provides a simple conceptual framework for the prediction and interpretation of changes in E/[A] curve profile resulting from exptl. interventions at the postreceptor (KE) level as well as at the receptor ([Ro]) level.

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