Detail of "59-63-2"

Reference

Effects of adrenalectomy on gonadal hormone-induced changes in hepatic microsomal carboxylesterase activities in rats

Effects of adrenalectomy on gonadal hormone-induced changes in hepatic microsomal carboxylesterase activities in rats. Hosokawa, Masakiyo; Satoh, Tetsuo; Ohkawara, Satoshi; Ohmori, Shigeru; Igarashi, Takashi; Ueno, Koichi; Kitagawa, Haruo (Fac. Pharm. Sci., Chiba Univ., Chiba, Japan). Res. Commun. Chem. Pathol. Pharmacol., 47(2), 285-8 (English) 1985. CODEN: RCOCB8. ISSN: 0034-5164. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Hepatic microsomal carboxylesterase (E.C. 3.1.1.1) [9016-18-6] showed a different capacity for the hydrolysis of various substrates after adrenalectomyin rats. Adrenalectomy in castrated male rats slightly decreased the activities towards p-nitrophenylacetate [830-03-5] and malathion [121-75-5]. Testosterone [58-22-0]-induced changes in hydrolase activities by liver microsomes in adrenalectomized-castrated male rats was markedly less than that in only castrated male rats. However, when 5a-dihydrotestosterone [521-18-6] was administered to adrenalectomized-castrated male rats, malathion and p-nitrophenylacetate hydrolase activities increased. In all cases, however, isocarboxazid [59-63-2] and acetanilide [103-84-4] hydrolase activities were not affected by physiol. states. Hepatic microsomal carboxylesterases may be, at least in part, regulated by adrenal and gonadal hormones which exert different effects on the several isozymes of carboxylesterases.

Determination of hydrazine in pharmaceuticals

Determination of hydrazine in pharmaceuticals. IV: Hydrazine and benzylhydrazine in isocarboxazid. Lovering, E. G.; Matsui, F.; Robertson, D.; Curran, N. M. (Bur. Drug Res., Health Welfare Canada, Ottawa, ON K1A 0L2, Can.). J. Pharm. Sci., 74(1), 105-7 (English) 1985. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) A gas chromatog. procedure for the simultaneous detn. of hydrazine [302-01-2] and benzylhydrazine [555-96-4] in isocarboxazide [59-63-2] bulk and tablet formulations is based on the reaction of benzoyltrifluoroacetone [326-06-7] with hydrazine and benzylhydrazine to form the corresponding pyrazole derivs. The min. detectable amts. of hydrazine and benzylhydrazine in isocarboxazide are 0.002 and 0.2%, resp.