CAS No.59-63-2,ISOCARBOXAZID (200 MG) Suppliers

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Basic Information

Molecular Structure:
CAS No.:	59-63-2
Name:	ISOCARBOXAZID (200 MG)
Article Data:	5

Formula:	C12H13 N3 O2
Molecular Weight:	231.254
Synonyms:	3-Isoxazolecarboxylicacid, 5-methyl-, 2-benzylhydrazide (6CI,7CI,8CI); 1-Benzyl-2-(5-methyl-3-isoxazolyl-carbonyl)hydrazine;5-Methyl-3-isoxazolecarboxylic acid 2-benzylhydrazide; BMIH; Benazide; Enerzer;Isocarboxazid; Isocarboxazide; Isocarboxyzid; Marplan; Marplon; NSC 169893;N'-Benzyl N-methyl-5-isoxazolecarboxylhydrazide-3; Ro 5-0831
Density:	1.206g/cm³
Melting Point:	98-1000C
Boiling Point:	394.5°Cat760mmHg
Flash Point:	192.4°C
Solubility:	0.8g/L(25 oC)
Safety:	A poison by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects: monoamine oxidase effects. Mutation data reported. A pharmaceutical and veterinary drug. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	67.16000
LogP:	2.19940

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Chemistry

IUPAC Name: N'-Benzyl-5-methyl-1,2-oxazole-3-carbohydrazide
Synonyms of Isocarboxazid (CAS NO.59-63-2) : 3-Isoxazolecarboxylic acid, 5-methyl-, 2-(phenylmethyl)hydrazide ; 5-Methyl-N'-(phenylmethyl)isoxazole-3-carbohydrazide ; N'-Benzyl-5-methyl-1,2-oxazole-3-carbohydrazide ; 3-(N-Benzylhydrazinocarbonyl)-5-methylisoxazole
Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
CAS NO:59-63-2
Molecular Formula:C₁₂H₁₃N₃O₂
Molecular Weight : 231.2505
Molecular Structure :
EINECS: 200-438-4
Index of Refraction:1.573
Surface Tension: 48.7 dyne/cm
Density: 1.206 g/cm³
Flash Point: 192.4 °C
Melting point: 98-100°C
Enthalpy of Vaporization: 64.45 kJ/mol
Boiling Point: 394.5 °C at 760 mmHg
Vapour Pressure: 1.97E-06 mmHg at 25°C
Appearance:Pale Yellow Solid

Uses

Isocarboxazid (CAS NO.59-63-2) (Enerzer, Marplan, Marplon) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class used as an antidepressant and anxiolytic. It is one of the few hydrazine MAOIs still in clinical use, along with phenelzine.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 40mg/kg (40mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Annals of the New York Academy of Sciences. Vol. 80, Pg. 626, 1959.
monkey	LD50	oral	160mg/kg (160mg/kg)		Annals of the New York Academy of Sciences. Vol. 80, Pg. 626, 1959.
mouse	LD50	intraperitoneal	138mg/kg (138mg/kg)		Journal of Medicinal and Pharmaceutical Chemistry. Vol. 2, Pg. 133, 1960.
mouse	LD50	oral	193mg/kg (193mg/kg)		Annals of the New York Academy of Sciences. Vol. 80, Pg. 626, 1959.
mouse	LD50	subcutaneous	150mg/kg (150mg/kg)		Toxicology and Applied Pharmacology. Vol. 39, Pg. 141, 1977.
rat	LD50	intraperitoneal	199mg/kg (199mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 240, 1972.
rat	LD50	oral	280mg/kg (280mg/kg)		Annals of the New York Academy of Sciences. Vol. 80, Pg. 626, 1959.
women	TDLo	oral	4800ug/kg/21W (4.8mg/kg)		Journal of Clinical Pyschopharmacology. Vol. 3, Pg. 42, 1983.
women	TDLo	oral	4800ug/kg/21W (4.8mg/kg)		Journal of Clinical Pyschopharmacology. Vol. 3, Pg. 42, 1983.

Safety Profile

A poison by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects: monoamine oxidase effects. Mutation data reported. A pharmaceutical and veterinary drug. When Isocarboxazid (CAS NO.59-63-2) is heated to decomposition, it emits toxic fumes of NO_x.

RIDADR 3249
HazardClass 6.1(b)
PackingGroup III