Reference

Stable pharmaceutical preparations, for oral use, containing homopyrimidazole derivatives

Stable pharmaceutical preparations, for oral use, containing homopyrimidazole derivatives. (Chinoin Gyogy es Vegyeszeti Termekek Gyara Rt., Hung.). Belg. BE 844449 16 Nov 1976, 16 pp. (Unavailable). (Belgium). CODEN: BEXXAL. CLASS: IC: A61K. PRIORITY: HU 75-1596 25 Jul 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Stable, analgesic prepns. for oral administration contain a homopyrimidazole deriv. I and a stabilizing acid. Normally, humidity which is adsorbed during processing of the pharmaceutical causes discoloration of the prepn. due to tautomeric transformation of I. However, this is prevented by adding an acid to the formulation to acidify the humidity. For example, 30 kg Probon (II) [28610-84-6], 3 kg cryst. cellulose, 0.6 kg hydrophobic colloidal, silicic acid, 0.3 kg betaine-HCl [590-46-5], and 0.1 kg stearin were mixed to give a fine powder, which was made into coated tablets.

Enzyme-containing digestive aid compostions

Enzyme-containing digestive aid compostions. Bilton, Gerald L. (USA ). U.S. US 4447412 A 8 May 1984,4 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K037-48; A61K009-42; A61K009-28. NCL: 424016000. APPLICATION: US 83-462995 1 Feb 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Oval compns. for decreasing the symptoms of digestive dysfunction contain a pancreatic enzyme ext., a protelytic enzyme from plants, a choleretic agent, a HCl source and pepsin [9001-75-6]. Bromelain [9001-00-7] and pancreatin [8049-47-6] were adsorbed onto digestible sucrose-starch beads which were coated with while lac glaze. These beads were then coated with stearic acid and carnauba wax. A mixt. of ox bile ext., pepsin, betaine-HCl [590-46-5] and guar gum was blended with H2O to give a dough which was screened, dried, and the resultant granules ground and dry-screened to the mesh. The granules were mixed with the coated beads and blended with hydrogenated vegetable oil, microcryst. cellulose, and Mg stearate. The mixt. was punched into tablets and coated with a zein soln.