Detail of "590371-81-6"

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Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids

Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids. Cottet, Fabrice; Schlosser, Manfred (Ecole Polytechnique Federale, Institut de Chimie moleculaire et biologique, CHLausanne 1015, Switz.). Tetrahedron, 60(51), 11869-11874 (English) 2004 Elsevier B.V. CODEN: TETRAB. ISSN: 0040-4020. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Although there are many conceivable ways to functionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prep. only 2-chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid from this precursor and 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl)pyridine into only the 4- and 6-carboxylic acids and to make the 3-carboxylic acid from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine. 590371-81-6 and 53939-30-3 are just another two chemicals used in this study. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. .