CAS No.59198-70-8,Pregna-1,4-diene-3,20-dione,6,9-difluoro-11-hydroxy-16-methyl-21-[(1-oxopentyl)oxy]-, (6a,11b,16a)- Suppliers

Detail of "59198-70-8"

CAS Number:

59198-70-8

Name:

Pregna-1,4-diene-3,20-dione,6,9-difluoro-11-hydroxy-16-methyl-21-[(1-oxopentyl)oxy]-, (6a,11b,16a)-

Superlist Name:

Diflucortolone valerate

Molecular Structure:

Formula:

C₂₇H₃₆F₂O₅

Molecular Weight:

478.63

Synonyms:

Diflucortolone21-valerate;6a,9-Difluoro-11b,21-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-valerate;Neriforte;Nerisona;Nerisone;Temetex;Texmeten;Travazol;

EINECS:

261-655-8

Density:

1.225 g/cm³

Melting Point:

220 °C

Boiling Point:

578.5 °C at 760 mmHg

Flash Point:

303.7 °C

Reference

An animal model for evaluating the local and systemic effects of topically applied corticosteroids on epidermal DNA synthesis: An animal model for evaluating the local and systemic effects of topically applied corticosteroids on epidermal DNA synthesis. Du Vivier, Anthony; Marshall, R. C.; Brookes, L. G. (Dermatol. Dep., St. Mary's Hosp., London, Engl.). Br. J. Dermatol., 98(2), 209-15 (English) 1978. CODEN: BJDEAZ. ISSN: 0007-0963. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 2 A simple animal model for studying topically applied glucocorticosteroids for their effect on epidermal DNA synthesis is described. It is designed so that their potential for systemic side effects may be predicted and its usefulness in this respect is illustrated by the results obtained with 2 of the steroids investigated. One, a new formulation Temetex [59198-70-8], is predicted to have considerable systemic potential. The other, Molivate (I) [25122-57-0], is remarkable for having moderate local, without demonstrable systemic activity.

Toxicity study of diflucortolone valerate: Toxicity study of diflucortolone valerate. 3. Chronic toxicity study in rat. Ezumi, Kichizo; Nakao, Hisao; Iwai, Katsumi; Ishimori, Kenmyo (Nihon Schering K. K. Lab., Osaka, Japan). Iyakuhin Kenkyu, 9(1), 36-63 (Japanese) 1978. CODEN: IYKEDH. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Diflucortolone valerate (I) [59198-70-8] (4 mg/kg/day, s.c. for 6 mo) given to rats decreased body wt. gain, leukocyte and lymphocyte counts, the wt. of the adrenal gland, thymus, and spleen, and induced the atrophy of the adrenal cortex and lymphatic tissues. These changes returned to normal after the cessation of I administration. The safe dose seems to be ~ 0.4 mg/kg.

Detail of "59198-70-8"

Pregna-1,4-diene-3,20-dione,6,9-difluoro-11-hydroxy-16-methyl-21-[(1-oxopentyl)oxy]-, (6a,11b,16a)-

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CAS No.59198-70-8 Diflucortolone valerate

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CAS No.59198-70-8 Diflucortolone valerate

CAS No.59198-70-8 Diflucortolone valerate

CAS No.59198-70-8 Diflucortolone valerate

CAS No.59198-70-8 Diflucortolone valerate

CAS No.59198-70-8 Diflucortolone valerate

CAS No.59198-70-8 Diflucortolone valerate

CAS No.59198-70-8 Diflucortolone valerate

Reference