Detail of "592-34-7"

Reference

Mydecamycin derivatives

Mydecamycin derivatives. Krausz, Francois; Calvet, Alain (CM Industries, Fr.). Ger. Offen.Chemicals with cas numbers 592-34-7 and 62622-16-6 also play role. DE 2629593 27 Jan 1977, 27 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07H017-08. PRIORITY: FR 75-21432 8 Jul 1975. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) Section cross-reference(s): 27, 63 Bactericidal mydecamycin (I, R = R1 = H) (II) esters I (R = H, R1 = R2XCO, R2 = Me, Et, Bu, Ph, Me2CHCH2, allyl, X = O, R2 = Me, Et, Pr, X = S) (9 compds.) and the 10,11,12,13-tetrahydro derivs. of I (R = H, R1 = Me, Et, Bu, allyl, X = O; R2 = Et, X = S) were prepd. by treatment II or tetrahydro deriv. of II in pyridine with R2XCOCl. Thus, 15 g II in pyridine was treated with EtO2CCl to give 13 g I (R = H, R1 = EtO2C), which (2.6 g) was treated with Ac2O to give 1.65 g I (R = Ac, R1 = EtO2C). I (R = Ac, R1 = EtO2C) at 200 mg/kg daily for 6 days in mice infected with diplococcus increased the survival time by 50% over the controls. .

Preparation of androstanol or androstenol alkyl carbonate derivatives

Preparation of androstanol or androstenol alkyl carbonate derivatives. Pan, Chaoyang; Tang, Jie; Jiang, Shengli; Yang, Fan; Chen, Jianhua; Hong, Yongyu (Xingye Chemicals Factory; Huadong Normal University, Peop. Rep.In this study， 648922-14-9 and 592-34-7 are also used. China). Faming Zhuanli Shenqing Gongkai Shuomingshu CN 1371912 A 2 Oct 2002, 10 pp. (Chinese). (People's Republic of China). CODEN: CNXXEV. CLASS: ICM: C07J003-00. ICS: C07J009-00. APPLICATION: CN 2002-110831 8 Feb 2002. DOCUMENT TYPE: Patent CA Section: 32 (Steroids) Androstanol I or androstenol alkyl carbonate derivs. (R = R' = R = R' = methoxycarboxy, propoxycarboxy, isopropoxycarboxy, butoxycarboxy, isobutoxycarboxy, tert-butoxycarboxy, benzyloxycarboxy, or cyclohexyloxycarboxy; when R not equal to R', one of the R or R' is the same as above mentioned, the other one is hydroxy or carbnyl), were prepd. from the esterification of alkyl chloroformate with the corresponding androstanol or androstenol. Thus, 1-androstene-3b,17b-diol dissolved in methylene chloride, mixed with triethylamine, and stirred under nitrogen atm., slowly added Me chloroformate to control the temp. 55 to 60° for five hours, then washed with 10% HCl and satd. NaCl soln., dried with anhyd. sodium sulfate, after concd. and column chromatograph with petroleum ether Et acetate as eluent, got the product with yield 96.2%. .