Detail of "59264-04-9"
- CAS Number:
- 59264-04-9
- Name:
Rifamycin,1,4-dideoxy-1,4-dihydro-30-hydroxy-1,4-dioxo-
- Molecular Structure:
- Formula:
- C37H45 N O13
- Synonyms:
- 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan,rifamycin deriv.; Rifamycin R
Rifamycin,1,4-dideoxy-1,4-dihydro-30-hydroxy-1,4-dioxo-
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Reference
- Rifamycins
- Rifamycins. White, Richard John; Lancini, Giancarlo; Antonini, Piero (Gruppo Lepetit S.p.A., Italy). Brit. GB 1470426 14 Apr 1977, 26 pp. (English). (United Kingdom). CODEN: BRXXAA. CLASS: IC: C12D009-14. APPLICATION: GB 74-37913 30 Aug 1974. DOCUMENT TYPE: Patent CA Section: 16 (Fermentations) Section cross-reference(s): 28 Rifamycin P [59232-87-0], rifamycin Q [59232-88-1], rifamycin R (I) [59264-04-9], and rifamycin U [59232-89-2] were obtained by cultivating mutant Nocardia mediterranea strains ATCC 31064(D-2), ATCC 31065(MM18-6), and ATCC 31066(M-36) under aerobic conditions in a nutrient medium contg. C and N sources and mineral salts at 25-37° for 180-200 h at pH 6.4-8.5. The fermn. broth was extd. with a H2O-immiscible solvent at pH <5; the rifamycins were sepd. by column chromatog. The mutant strains were prepd. by treating a suspension of spores of Streptomyces mediterranei ATCC 13685 with N-methyl-N'-nitro-N-nitrosoguanidine at pH 9 and ~28°, incubating the treated spores, and isolating the surviving colonies which were able to inhibit the growth of Bacillus subtilis. The antibiotic activities of the rifamycins were assessed in vitro against a variety of organisms and in mice injected with Staphylococcus aureus or Escherichia coli. Rifamycin P, the most active compd., showed ED50 0.3 mg/kg on s.c. administration to S. aureus-infected mice; LD50 for rifamycin P in mice was >500 mg/kg i.p.