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| CAS No.: | 593-51-1 |
|---|---|
| Name: | Methylamine hydrochloride |
| Article Data: | 100 |
| Molecular Structure: | |
|
|
|
| Formula: | CH6ClN |
| Molecular Weight: | 67.5183 |
| Synonyms: | Methanamine,hydrochloride (9CI);Methanaminium chloride;Methylamine monohydrochloride;Methylammonium chloride; |
| EINECS: | 209-795-0 |
| Density: | 0.8306 (rough estimate) |
| Melting Point: | 231-233 °C(lit.) |
| Boiling Point: | 38.2 °C at 760 mmHg |
| Flash Point: | 225-230°C/15mm |
| Solubility: | soluble in water |
| Appearance: | white to light tan solid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22-36/37/38 |
| Safety: | 26-37/39 |
| PSA: | 26.02000 |
| LogP: | 1.07720 |
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- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
| Conditions | Yield |
|---|---|
| With hydrogenchloride | A n/a B 99% |
- 39885-14-8
N-Nitroso-N-methylmethoxymethylamine
- 593-51-1
methylamine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol for 2h; Heating; | 97% |
- 115584-91-3
(E)-2-Chloro-3-hydroxy-but-2-enoic acid methyl ester
- 109-89-7
diethylamine
A
- 593-51-1
methylamine hydrochloride
| Conditions | Yield |
|---|---|
| In diethyl ether at -40℃; for 1h; | A n/a B 96% |
- 650-52-2
bis(trifluoromethyl)chlorophosphine
A
- 431-98-1
methylamino-bis-trifluoromethyl-phosphine
B
- 593-51-1
methylamine hydrochloride
| Conditions | Yield |
|---|---|
| With CH3NH2 In gaseous matrix 0°C; | A 95% B n/a |
- 18197-25-6
N-formyl-N-methylformamide
- 593-51-1
methylamine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In ethanol; water for 168h; Ambient temperature; | 94% |
- 77287-34-4, 77287-35-5, 60100-09-6
formamide
- 593-51-1
methylamine hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: formamide With bis(tetrahydrofuran)calcium di(bis(trimethylsilyl)amide); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 120℃; for 36h; Inert atmosphere; Schlenk technique; Stage #2: With hydrogenchloride In diethyl ether; toluene Inert atmosphere; Schlenk technique; | 90% |
| Stage #1: formamide With [(aNHC)KN(SiMe3)2]2; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 40℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique; Stage #2: With water; sodium hydroxide In diethyl ether; toluene at 40℃; for 1h; Inert atmosphere; Glovebox; Schlenk technique; Stage #3: With hydrogenchloride In diethyl ether; water Inert atmosphere; Glovebox; Schlenk technique; | 98 %Spectr. |
| Conditions | Yield |
|---|---|
| Stage #1: glycine With (R)-Carvone In propan-1-ol at 20 - 190℃; under 11251.1 Torr; for 0.216667h; Sealed tube; Microwave irradiation; Stage #2: With hydrogenchloride In propan-1-ol; water at 190℃; for 0.0833333h; Microwave irradiation; | 86% |
- 593-51-1
methylamine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In propan-1-ol at 190℃; for 0.216667h; Temperature; Microwave irradiation; Green chemistry; | 86% |
| Conditions | Yield |
|---|---|
| In ethanol; dichloromethane under N2 soln. Mo(HB(Me2pyz)3)(NO)Cl2 in dichloromethane treated with methylamine (33% ethanolic soln.) and mixt. stirred at room temp. for 30 min; volume solvent reduced in vacuo, Et2O added, (NH3Me)Cl filtered off, filtrate reduced in vacuo; elem. anal.; | A 83% B n/a |
| Conditions | Yield |
|---|---|
| Stage #1: nitromethane With hydrazine hydrate; zinc In methanol at 20℃; for 0.0666667h; Stage #2: With hydrogenchloride | 80% |
| With hydrogenchloride; zinc; hydrazinium monoformate In water for 0.0416667h; | 75% |
| Stage #1: nitromethane With formic acid; nickel In methanol at 20℃; for 0.0833333h; Reduction; Stage #2: With hydrogenchloride Addition; | 45% |
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Specification
The IUPAC name of this chemical is Methanamine,hydrochloride. With the CAS registry number 593-51-1 and EINECS registry number 209-795-0, it is also named as methanaminium chloride. In addition, the molecular formula is CH6ClN. It is a kind of white to light tan solid and incompatible with strong oxidizing agents. And it may be sensitive with moisture. In addition, it can be used as a reagent for the analysis and used for organic synthesis.
Physical properties about Methylamine hydrochloride are:
(1)ACD/LogP: -0.66; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.76; (4)ACD/LogD (pH 7.4): -3.54; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)Enthalpy of Vaporization: 25.6 kJ/mol; (12)Boiling Point: 38.2 °C at 760 mmHg; (13)Vapour Pressure: 3970 mmHg at 25°C.
Preparation of Methylamine hydrochloride:
It can be prepared by carboamine solution. Add the hydrochloric acid into the carboamine solution. The pH value should be controlled at 2-3. And then after a series of decoloring, filtration, concentration and crystallization you can get the desired product. The equation is as follows:
Uses of Methylamine hydrochloride:
It can be used to get methylsulfamoyl chloride. This reaction will need reagent SO2Cl2, catalyst SbCl5 and solvent acetonitrile. The yield is about 66%.
Safety information of Methylamine hydrochloride:
When you are using Methylamine hydrochloride, please be cautious about it as the following:This chemical is harmful if swallowed. It is irritating to eyes, respiratory system and skin. Whenever you will contact it, please wear gloves and eye/face protection. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: [Cl-].[NH3+]C
(2)InChI: InChI=1/CH5N.ClH/c1-2;/h2H2,1H3;1H
(3)InChIKey: NQMRYBIKMRVZLB-UHFFFAOYAJ
The toxicity data of Methylamine hydrochloride is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | skin | > 2gm/kg (2000mg/kg) | Kodak Company Reports. Vol. 21MAY1971, | |
| mouse | LD50 | intraperitoneal | 2160mg/kg (2160mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977. | |
| rat | LD50 | oral | 1600mg/kg (1600mg/kg) | Inhalation Toxicology. Vol. 2, Pg. 29, 1990. |
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