Detail of "5933-40-4"

Reference

Cyclic b-iminophosphine: New P-stereogenic ligand for the asymmetric catalysed hydrogenation of ketones

All Rights Reserved. Cyclic b-iminophosphine: New P-stereogenic ligand for the asymmetric catalysed hydrogenation of ketones. Christ, M. Lorraine; Zablocka, Maria; Spencer, Sally; Lavender, Rebecca J.; Lemaire, Marc; Majoral, Jean Pierre (Laboratoire de Catalyse et Synthese Organique, CNRS, Villeurbanne 69622, Fr.). Journal of Molecular Catalysis A: Chemical, 245(1-2), 210-216 (English) 2006 Elsevier B.V. CODEN: JMCCF2. ISSN: 1381-1169. DOCUMENT TYPE: Journal CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Section cross-reference(s): 29, 78 A novel type of asym. C=O hydrogenation catalysts based on chiral b-iminophosphine rhodium and ruthenium complexes was developed. The chirality of the ligand is centered on the phosphorus atom which can induce moderate enantioselectivity. A synergetic effect on both activity and enantioselectivity is obsd. 5933-40-4 and 1445-91-6 which are cas registry numbers of substances are two of reagents here. when amines are introduced as co-ligands. Acetophenone is thus completely hydrogenated with ee values up to 68%. .

Preparation of optically active 5,9-methanocycloocta[b]pyridines as intermediates for anti-Alzheimer's (-)-huperzine A

Preparation of optically active 5,9-methanocycloocta[b]pyridines as intermediates for anti-Alzheimer's (-)-huperzine A. Terajima, Atsuro; Yoshino, Toshiji; Nakajima, Noryuki (Sagami Chem Res, Japan). Jpn. 5933-40-4 and 185741-46-2 are also occured in this study. Kokai Tokkyo Koho JP 08301850 A2 19 Nov 1996 Heisei, 10 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: C07D221-22. ICS: C07M007-00. APPLICATION: JP 1995-107475 1 May 1995. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 The title compds. I [R1, R2 = (substituted) alkyl, silyl] are prepd. by treating hydroxydihydroquinolines II (R1, R2 = same as I) with methacrolein in the presence of optically active bases, sulfonylation of the resulting optically active adducts III (R1, R2 = same as I, X = H), and desulfonation of III (X = sulfonyl group). II (R1 = R2 = Me) was treated with methacrolein and cinchonidine in CH2Cl2-PhMe at -10° for 253 h to give 45% III (R1 = R2 = Me, X = H), which was sulfonylated by MeSO3Cl, NEt3, and 4-dimethylaminopyridine in CH2Cl2 at room temp. for 2 h to give 77% III (R1 = R2 = Me, X = MeSO2). Treatment of the sulfonate with AcONa/AcOH at 120° for 24 h gave 60% (+)-I (R1 = R2 = Me) with 64.1% ee, which was converted into (-)-huperzine A in 5 steps. .