Detail of "59588-86-2"

CAS Number:
59588-86-2
Name:
Alamethicin I
Molecular Structure:
Formula:
C92H150 N22 O25
Molecular Weight:
1964.31
Deleted CAS:
66473-80-1
Synonyms:
Alamethicin(synthetic Trichoderma viride);Alamethicin F 30;Alamethicin RF 30;Alamethicin g;Antibiotic U 22324;L-Glutamamide,N-acetyl-2-methylalanyl-L-prolyl-2-methylalanyl-L-alanyl-2-methylalanyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-valyl-2-methylalanylglycyl-L-leucyl-2-methylalanyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-a-glutamyl-N1-[1-(hydroxymethyl)-2-phenylethyl]-,(S)-;
Melting Point:
277-278ºC
Solubility:
Soluble in DMSO and ethanol
Appearance:
Tan or light brown solid
Hazard Symbols:
T
Risk Codes:
25
Safety:
45 Details
Transport Information:
UN 3462 6

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Synthesis of a 19-residue peptide with alamethicin-like activity: Synthesis of a 19-residue peptide with alamethicin-like activity. Gisin, Balthasar F.; Kobayashi, Shigeru; Hall, James E. (Dep. Biochem., Rockefeller Univ., New York, N. Y., USA). Proc. Natl. Acad. Sci. U. S. A., 74(1), 115-19 (English) 1977. CODEN: PNASA6. DOCUMENT TYPE: Journal CA Section: 34 (Synthesis of Amino Acids, Peptides, and Proteins) A compd. with voltage-gating characteristics similar to those obsd. in nerve membranes was prepd. The open chain sequence of alamethicin (ALA-o) proposed by Martin and Williams (1976) was synthesized by stepwise solid-phase condensation of 4 fragments and was not identical with the main component of natural ALA. In lipid bilayer membranes the exponential dependence of cond. on voltage and the dependence of cond. on a high power of the peptide concn. were qual. similar for ALA-o and for natural ALA.In this experiment, several chemicals are used like 59588-86-2 and 62571-14-6 ALA-o showed the characteristics of a channel-former, although the single-channel conductances were less well defined for the synthetic compd. A cyclic structure is not necessary for a peptide to induce voltage-depended conds. in membranes. .