CAS No.5961-59-1,N-METHYL-P-ANISIDINE Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	5961-59-1
Name:	N-METHYL-P-ANISIDINE
Article Data:	207

Formula:	C₈H₁₁NO
Molecular Weight:	137.181
Synonyms:	p-Anisidine,N-methyl- (7CI,8CI);4-(Methylamino)anisole;4-Methoxy-N-methylaniline;4-Methoxy-N-methylbenzenamine;N-(4-Methoxyphenyl)-N-methylamine;
EINECS:	227-735-1
Density:	1.032 g/cm³
Melting Point:	33-36 °C(lit.)
Boiling Point:	252.4 °C at 760 mmHg
Flash Point:	87.2 °C
Appearance:	white to greyish-brown crystal. low melting mass
Hazard Symbols:
Risk Codes:	20/21/22
Safety:	22-24/25-36/37
PSA:	21.26000
LogP:	1.80990

Synthetic route

: 7451-55-0
ethyl 4-methoxyphenylcarbamate

: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating / reflux;	100%
With lithium aluminium tetrahydride In tetrahydrofuran at 60℃;
With lithium aluminium tetrahydride In diethyl ether Inert atmosphere; Reflux;

: 50-00-0
formaldehyd

: 104-94-9
4-methoxy-aniline

: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

Conditions

Conditions	Yield
With butyl triphenylphosphonium tetraborate at 20℃; for 0.183333h;	99%
With 3 weight% Pd/C; hydrogen In methanol at 80℃; under 3800.26 Torr; Reagent/catalyst; Autoclave;	94.2%
Stage #1: formaldehyd; 4-methoxy-aniline With sodium methylate In methanol at 20℃; for 5h; Stage #2: With sodium tetrahydroborate In methanol for 1.75h; Heating;	80%

: 67-56-1
methanol

: 104-94-9
4-methoxy-aniline

: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

Conditions

Conditions	Yield
With cesiumhydroxide monohydrate; (1,4-dimethyl-5,7-diphenyl-1,2,3,4-tetrahydro-6H-cyclopenta[b]pyrazin-6-one) irontricarbonyl complex3 at 110℃; Catalytic behavior; Reagent/catalyst; Temperature; Schlenk technique; Inert atmosphere;	99%
With potassium tert-butylate; C49H50Cl2Ir2N5O(1+)*F6P(1-) at 130℃; for 4h;	99%
With C12H16IrN4O2(1+)*BF4(1-); potassium hydroxide at 120℃; for 5h; Irradiation; Inert atmosphere; Sealed tube;	95%

: 108874-78-8
N-(4-methoxyphenyl)-N-methyl-S-phenylthiohydroxylamine

A: 882-33-7
diphenyldisulfane

B: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In acetonitrile for 0.166667h; Mechanism; Product distribution; Ambient temperature; various solvents, Lewis acids, and N-methylbenzenesulfenanilide;	A 97% B 40%

: 4-cyano-N-(4-methoxyphenyl)-N-methylbenzenesulfonamide

: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-dodecylthiol In water; N,N-dimethyl-formamide for 12h; Inert atmosphere;	97%

: 5279-51-6
4-methoxy-N-methylformanilide

: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

Conditions

Conditions	Yield
With C18H37ClMoNO2P2; hydrogen; sodium triethylborohydride In tetrahydrofuran; toluene at 130℃; under 37503.8 Torr; for 24h; Autoclave; Glovebox;	96%
With hydrogenchloride In water for 1.5h; Reflux;	74%
With water Heating; Yield given;
With aluminum oxide; potassium fluoride for 0.333333h; microwave irradiation;

: tert-butyl (4-methoxyphenyl)methylcarbamate

: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 25℃;	96%
With trifluoroacetic acid In dichloromethane at 40℃; for 48h; Inert atmosphere; Schlenk technique;
With hydrogenchloride In water at 120℃;

: 35813-38-8
N-(4-methoxyphenyl)-N-methylacetamide

A: 6114-15-4
4-methoxy-N-ethyl-N-methylaniline

B: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

Conditions

Conditions	Yield
With triethyl borane; Triethoxysilane; sodium hydroxide In hexane at 80℃; for 6h; Reagent/catalyst; Solvent; Inert atmosphere; Sealed tube;	A 3% B 96%
With sodium triethylborohydride In tetrahydrofuran at 80℃; for 12h; Inert atmosphere; Schlenk technique; Glovebox; Sealed tube;	A n/a B 72%
With sodium triethylborohydride In tetrahydrofuran at 80℃; for 6h; Inert atmosphere; Schlenk technique; High pressure; Sealed tube;	A n/a B 72%

: 67-56-1
methanol

: 100-17-4
para-methoxynitrobenzene

: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

Conditions

Conditions	Yield
With potassium tert-butylate; C49H50Cl2Ir2N5O(1+)*F6P(1-) at 130℃; for 10h;	96%
With [iridium(I)Br(carbonyl)2(κ1C-tBuImCH2PyCH2OMe)]; caesium carbonate at 129.84℃; for 5h; Catalytic behavior; Mechanism; Inert atmosphere; Glovebox; Green chemistry;	92%
With rhodium(III) chloride hydrate; potassium tert-butylate at 130℃; for 48h; Sealed tube; High pressure;	82%

: 35813-38-8
N-(4-methoxyphenyl)-N-methylacetamide

: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

Conditions

Conditions	Yield
Stage #1: N-(4-methoxyphenyl)-N-methylacetamide With sulfuric acid; water for 2h; Heating / reflux; Stage #2: With sodium hydroxide; water Product distribution / selectivity;	95.86%
With potassium methanolate; C26H32MnN4O4 In butan-1-ol at 135℃; for 45h;	63%
With hydrogenchloride In water; ethylene glycol for 24h; Reflux; Inert atmosphere;
With hydrogenchloride In water; ethylene glycol at 20℃; for 3h; Inert atmosphere;

Raw Materials

106-49-0

141814-27-9

106-40-1

109-99-9

74-88-4

106-47-8

123-30-8

104-94-9

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Chemistry

IUPAC Name: 4-methoxy-N-methylaniline
Synonyms of N-Methyl-4-anisidine (CAS NO.5961-59-1): 1-Methylamino-4-methoxybenzene ; 4-Methoxy-N-methylaniline ; 4-Methoxy-N-methylbenzenamine ; N-Methyl-p-anisidine ; p-Methoxy-N-methylaniline ; Benzenamine, 4-methoxy-N-methyl- (9CI) ; p-Anisidine, N-methyl- (8CI)
CAS NO: 5961-59-1
Molecular Formula: C₈H₁₁NO
Molecular Weight: 137.18
Molecular Structure:
EINECS: 227-735-1
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 2
Polar Surface Area: 12.47 Å²
Index of Refraction: 1.553
Molar Refractivity: 42.54 cm³
Molar Volume: 132.8 cm³
Surface Tension: 34.8 dyne/cm
Density: 1.032 g/cm³
Flash Point: 87.2 °C
Enthalpy of Vaporization: 48.98 kJ/mol
Boiling Point: 252.4 °C at 760 mmHg
Vapour Pressure: 0.0194 mmHg at 25°C
Melting Point: 33-36 °C(lit.)
Appearance: white to greyish-brown crystal. low melting mass
SMILES: O(c1ccc(NC)cc1)C
InChI: InChI=1/C8H11NO/c1-9-7-3-5-8(10-2)6-4-7/h3-6,9H,1-2H3
InChIKey: JFXDIXYFXDOZIT-UHFFFAOYAN
Std. InChI: InChI=1S/C8H11NO/c1-9-7-3-5-8(10-2)6-4-7/h3-6,9H,1-2H3
Std. InChIKey: JFXDIXYFXDOZIT-UHFFFAOYSA-N
Product Categories of N-Methyl-4-anisidine (CAS NO.5961-59-1): Aromatics

Safety Profile

Safety Information about N-Methyl-4-anisidine (CAS NO.5961-59-1):
Hazard Codes: Harmful Xn
Risk Statements: 20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-24/25-36/37
S22:Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
S36/37: Wear suitable protective clothing and gloves.
WGK Germany: 3
F: 10

Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container.