Detail of "5967-84-0"

Reference

Preparation of pellets containing theophylline

Preparation of pellets containing theophylline. Musko, Zsolt; Bajdik, Janos; Pintye-Hodi, Klara; Szabo-Revesz, Piroska; Kelemen, Andras; Eros, Istvan (Department of Pharmaceutical Technology, University of Szeged, Szeged, Hung.). Pharmazeutische Industrie, 64(11), 1194-1198 (English) 2002 Editio Cantor Verlag. CODEN: PHINAN. ISSN: 0031-711X. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The aim of this work was to prep. theophylline (CAS 5967-84-0) pellets by using a centrifugal granulator. Theophylline crystals have unsuitable powder rheol. properties. Wet granulation was necessary and pellets with different particle sizes were prepd. The habit of the pellets was spherical, with a compact texture. The process of pellet deformation was tested by means of a modified equipment, and the force-time curve is presented. Use of a centrifugal granulator with the parameters applied resulted in theophylline pellets with suitable parameters (shape, texture, deformation behavior and dissoln.). The particle size influenced the flow properties and the deformation parameters but it had no influence on the dissoln. rate of active agent.

In situ measurement of solvent-mediated phase transformations during dissolution testing

All Rights Reserved. In situ measurement of solvent-mediated phase transformations during dissolution testing. Aaltonen, Jaakko; Heinanen, Paula; Peltonen, Leena; Korteiarvi, Hanna; Tanninen, Veli Pekka; Christiansen, Leena; Hirvonen, Jouni; Yliruusi, Jouko; Rantanen, Jukka (Division of Pharmaceutical Technology, University of Helsinki 00014, Finland). Journal of Pharmaceutical Sciences, 95(12), 2730-2737 (English) 2006 Wiley-Liss, Inc. CODEN: JPMSAE.Chemicals with cas numbers 67-20-9 and 5967-84-0 also play role. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) In this study, solvent-mediated phase transformations of theophylline (TP) and nitrofurantoin (NF) were measured in a channel flow intrinsic dissoln. test system. The test set-up comprised simultaneous measurement of drug concn. in the dissoln. medium (with UV-Vis spectrophotometry) and measurement of the solid-state form of the dissolving solid (in situ with Raman spectroscopy). The solid phase transformations were also investigated off-line with SEM. TP anhydrate underwent a transformation to TP monohydrate, and NF anhydrate (form b) to NF monohydrate (form II). Transformation of TP anhydrate to TP monohydrate resulted in a clear decrease in the dissoln. rate, while the transformation of NF anhydrate (form b) to NF monohydrate (form II) could not be linked as clearly to changes in the dissoln. rate. The transformation of TP was an order of magnitude faster than that of NF. The presence of a water absorbing excipient, microcryst. cellulose, was found to delay the onset of the transformation of TP anhydrate. Combining the measurement of drug concn. in the dissoln. medium with the solid phase measurement offers a deeper understanding of the solvent-mediated phase transformation phenomena during dissoln. .