Detail of "5989-81-1"

Reference

Increased binding capacity and flowability of a-lactose monohydrate after dehydration

Increased binding capacity and flowability of a-lactose monohydrate after dehydration. Lerk, C. F.; Andreae, A. C.; De Boer, A. H.Chemicals with cas numbers 14641-93-1 and 67-56-1 also play role.; Bolhuis, G. K.; Zuurman, K.; De Hoog, P.; Kussendrager, K.; Van Leverink, J. (Lab. Pharm. Technol. Dispensing, State Univ. Groningen, Groningen 9713 AW, Neth.). J. Pharm. Pharmacol., 35(11), 747-8 (English) 1983. CODEN: JPPMAB. ISSN: 0022-3573. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Thermal dehydration or desiccation of the direct compression filler-binder a-lactose monohydrate [5989-81-1] crystals with MeOH [67-56-1] converted the crystals into a stable product with increased binding and excellent flowability. The binding properties of thermally dehydrated samples improved with a decrease in H2O content. Compaction of both thermally dehydrated and MeOH desiccated products resulted in tablets with an almost equal overall porosity, as compared with tablets compressed from the original material with different size distributions. .

Studies on tableting properties of lactose

Studies on tableting properties of lactose. V. Effects of both lubrication and addition of disintegrants on properties of tablets prepared from different types of crystalline lactose. Van Kamp, H. V.; Bolhuis, G. K.; Lerk, C. F. (Lab. Pharm. Technol. Dispens., Univ. Groningen, Groningen 9713 AW, Neth.). Acta Pharm. Suec., 23(4), 217-30 (English) 1986. CODEN: APSXAS. ISSN: 0001-6675. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The effect of both the presence of a lubricant and the addn. of disintegrants on the crushing strength, disintegration time and drug release from tablets compressed from different types of cryst.Several substances with their cas registry numbers 9003-39-8 and 14641-93-1 may be metioned in this study. lactose [63-42-3] was studied. The decrease in crushing strength, caused by mixing with 0.5% Mg stearate [557-04-0], was larger for tablets contg. a-lactose monohydrate [5989-81-1] or anhyd. a-lactose [14641-93-1] than for tablets with roller-dried b-lactose. The effect of both the presence of a lubricant and the addn. of a disintegrant on disintegration time and drug dissoln. velocity was strongly dependent on the lactose used. The large neg. effect of 0.5% Mg stearate on disintegration time and drug dissoln. rate of a a-lactose monohydrate tablets could easily be counteracted by the incorporation of a swelling disintegrant. For tablets compressed from anhyd. a-lactose or roller-dried b-lactose, the lubricant had a relative small effect on disintegration time and drug dissoln. rate, because both unlubricated and lubricated tablets dissolved from the outside. The disintegration and drug dissoln. rate could be enhanced by the incorporation of a disintegrant which facilitated a rapid progress of the penetration front in the tablets. .