Detail of "599179-03-0"

Reference

Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome p450 enzymes and membrane efflux systems following vaginal and oral cavity administration

All Rights Reserved. Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome p450 enzymes and membrane efflux systems following vaginal and oral cavity administration. Pauletti, Giovanni M.Several substances are used for example 599179-03-0 which is its cas registry number.; Harrison, Donald C.; Desai, Kishorkumar J. ( USA ). U.S. Pat. Appl. Publ. US 2007036834 A1 15 Feb 2007,24pp., Cont.-in-part of U.S. Ser. No. 208,209. (English). (United States of America). CODEN: USXXCO. INCL: 424426000; 424486000; 424725000; 424756000; 424736000; 424737000; 424726000; 424733000; 424734000; 424764000. APPLICATION: US 2006-522126 15 Sep 2006. PRIORITY: US 2001-315877P 29 Aug 2001; US 2002-226667 21 Aug 2002; US 2005-208209 18 Aug 2005; US 2005-717680P 15 Sep 2005. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The present invention relates to a method for augmentation of epithelial concn. and systemic exposure of therapeutic agents having a substrate affinity for cytochrome P 450 enzymes and membrane efflux transporter systems by using a vaginal or buccal drug delivery compns. and/or devices. Specifically, the invention relates to a method for augmentation of intraepithelial concn. and/or systemic bioavailability for delivery of anti-viral and/or anti-cancer therapeutic agents having a substrate affinity for cytochrome P 450 enzymes and membrane efflux systems by using a vaginal or buccal drug delivery of these drugs into the systemic circulation by delivering such drug to a subject in need thereof vaginally or buccally in an esp. formulated compn. increasing the drug's bioavailability by providing means for increasing the drug soly. and permeability through the vaginal or buccal mucosa. .