Reference

Electrochemical oxidation of L-prolinol derivative protected with 1-alkoxy-2,2,2-trifluoroethyl group

All Rights Reserved. Electrochemical oxidation of L-prolinol derivative protected with 1-alkoxy-2,2,2-trifluoroethyl group. Onomura, Osamu; Ishida, Yukihiro; Maki, Toshihide; Minato, Daishirou; Demizu, Yosuke; Matsumura, Yoshihiro (Fac. Pharmaceutical Sci., Grad. 59936-29-7 and 917956-28-6 are cas registry numbers. These chemicals are also mentioned in this article. Sch. Biomed. Sci., Nagasaki Univ. 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan). Electrochemistry (Tokyo, Japan), 74(8), 645-648 (English) 2006 Electrochemical Society of Japan. CODEN: EECTFA. ISSN: 1344-3542. DOCUMENT TYPE: Journal CA Section: 72 (Electrochemistry) Section cross-reference(s): 22 1-Alkoxy-2,2,2-trifluoroethyl group is a new protecting group for electrochem. oxidn. of L-prolinol. The result is a 1st example for the introduction of a nucleophile to a-position of L-prolinol without a loss of the optical activity through an iminium ion intermediate. This exploited method is complementary for methods in which an electrophile is introduced to the a-position of L-proline deriv. through a carbanion intermediate. .