CAS No.60-56-0,Methimazole Suppliers,MSDS download

Products Categories

Pharmaceutical (177)
Organic Chemicals (39)
Others (24)
Reagent (8)
Materials (7)
Plant Extract (4)
Basic Inorganic Chemicals (2)
Catalyst and Auxiliary (2)

Basic Information

Molecular Structure:
CAS No.:	60-56-0
Name:	Methimazole
Article Data:	31

Formula:	C₄H₆N₂S
Molecular Weight:	114.171
Synonyms:	4-Imidazoline-2-thione,1-methyl- (6CI,7CI);Imidazole-2-thiol, 1-methyl- (8CI);1-Methyl-1H-imidazole-2-thiol;1-Methyl-2-mercapto-1H-imidazole;1-Methyl-4-imidazoline-2-thione;1-Methylimidazole-2-thiol;1-Methylimidazole-2-thione;Basolan;Danantizol;Mercaptazole;Mercazole;Mercazolyl;
EINECS:	200-482-4
Density:	1.28 g/cm³
Melting Point:	144-147 °C(lit.)
Boiling Point:	154.8 °C at 760 mmHg
Flash Point:	47.4 °C
Solubility:	soluble in water
Appearance:	White Solid
Hazard Symbols:	Xn
Risk Codes:	43-62-63
Safety:	26-27-45-36/37
PSA:	56.62000
LogP:	0.70880

Synthetic route

: 79487-94-8
2-tert-butylthio-1-methyl-1H-imidazole

: 60-56-0
2-Mercapto-1-methylimidazole

Conditions

Conditions	Yield
With aluminum (III) chloride at 20℃; Reagent/catalyst; Inert atmosphere;	91%

: 616-47-7
1-methyl-1H-imidazole

: 60-56-0
2-Mercapto-1-methylimidazole

Conditions

Conditions	Yield
Stage #1: 1-methyl-1H-imidazole With n-butyllithium In tetrahydrofuran; hexane at -10℃; for 1.5h; Stage #2: With sulfur In tetrahydrofuran; hexane for 9h; Temperature; Reflux;	82.54%

: S-2-(1-methyl)imidazolyl ethanethioate

: 60-56-0
2-Mercapto-1-methylimidazole

Conditions

Conditions	Yield
With hydrogenchloride In isopropyl alcohol at 20℃; for 5h; Solvent;	77%

: 63348-55-0
2-(benzylthio)-1-methyl-1H-imidazole

A: 23269-08-1
3-methyl-1-benzyl-1,3-dihydroimidazole-2-thione

B: 60-56-0
2-Mercapto-1-methylimidazole

Conditions

Conditions	Yield
In methanol for 5h; Irradiation;	A 168 mg B 88 mg

: 7647-01-0
hydrogenchloride

: 333-20-0
potassium thioacyanate

: 20677-73-0
N-methylaminoacetaldehyde diethyl acetal

: 60-56-0
2-Mercapto-1-methylimidazole

...Expand

: 90203-43-3
N-(2,2-diethoxy-ethyl)-N'-methyl-thiourea

H2SO4 (diluted ): H2SO4 (diluted )

: 60-56-0
2-Mercapto-1-methylimidazole

: 3129-90-6
isothiocyanic acid

: 20677-73-0
N-methylaminoacetaldehyde diethyl acetal

: 60-56-0
2-Mercapto-1-methylimidazole

: 2,2'-dithiodi(1-methylimidazole) bis(perchloric acid) salt

A: 616-47-7
1-methyl-1H-imidazole

B: 60-56-0
2-Mercapto-1-methylimidazole

Conditions

Conditions	Yield
With Carbonate buffer at 25℃; Kinetics;

: 333-20-0
potassium thioacyanate

: 20677-73-0
N-methylaminoacetaldehyde diethyl acetal

: 60-56-0
2-Mercapto-1-methylimidazole

Conditions

Conditions	Yield
With hydrogenchloride In water at 20 - 30℃; Large scale;	150 kg

: 540-72-7
sodium thiocyanide

: 122-07-6
N-(methyl)aminoacetaldehyde dimethyl acetal

: 60-56-0
2-Mercapto-1-methylimidazole

Conditions

Conditions	Yield
With hydrogenchloride In water at 20 - 60℃; pH=1 - 2;	0.86 kg

Raw Materials

333-20-0

Downstream Products

616-47-7

Total:176 Page 1 of 5 1 2 3 4 5 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 60-56-0

Chemistry

IUPAC Name: 3-Methyl-1H-imidazole-2-thione
Synonyms of Methimazole (CAS NO.60-56-0): 1,3-Dihydro-1-methyl-2H-imidazole-2-thione ; 1-Methyl-1,3-dihydroimidazole-2-thione ; 1-Methyl-2-mercaptoimidazole ; 1-Methylimidazole-2-thiol ; 2-Mercapto-1-methylimidazole ; 4-Imidazoline-2-thione, 1-methyl- ; Favistan ; Mercazolylum ; N-Methyl-2-mercaptoimidazole
CAS NO: 60-56-0
Molecular Formula: C₄H₆N₂S
Molecular Weight: 114.16
Molecular Structure:
EINECS: 200-482-4
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 0
Polar Surface Area: 38.57 Å²
Index of Refraction: 1.666
Molar Refractivity: 33.07 cm³
Molar Volume: 88.8 cm³
Surface Tension: 61.9 dyne/cm
Density: 1.28 g/cm³
Flash Point: 47.4 °C
Enthalpy of Vaporization: 39.15 kJ/mol
Boiling Point: 154.8 °C at 760 mmHg
Vapour Pressure: 3.13 mmHg at 25°C
Melting point: 140-145 °C
Water solubility: soluble
Appearance: White Solid
SMILES: S=C1N(\C=C/N1)C
InChI: InChI=1/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
InChIKey: PMRYVIKBURPHAH-UHFFFAOYAN
Std. InChI: InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
Std. InChIKey: PMRYVIKBURPHAH-UHFFFAOYSA-N
SMILES: S=C1N(\C=C/N1)C
InChI: InChI=1/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
InChIKey: PMRYVIKBURPHAH-UHFFFAOYAN
Std. InChI: InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
Std. InChIKey: PMRYVIKBURPHAH-UHFFFAOYSA-N
Product Categories of Methimazole (CAS NO.60-56-0): Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals

Uses

Methimazole (CAS NO.60-56-0) is used as a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	500mg/kg (500mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	oral	860mg/kg (860mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 20, 1954.
mouse	LD50	subcutaneous	345mg/kg (345mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 20, 1954.
rat	LD50	oral	2250mg/kg (2250mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 20, 1954.
rat	LD50	subcutaneous	1050mg/kg (1050mg/kg)		Farmaco, Edizione Scientifica. Vol. 14, Pg. 54, 1959.
women	TDLo	oral	13mg/kg/33D-I (13mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EAR BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: OTHER CHANGES	Clinical Endocrinology Vol. 51, Pg. 667, 1999.
women	TDLo	oral	492mg/kg/88W- (492mg/kg)	ENDOCRINE: CHANGE IN GONADOTROPINS BLOOD: AGRANULOCYTOSIS	Netherlands Journal of Medicine. Vol. 43, Pg. 71, 1993.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 43-62-63
43: May cause sensitization by skin contact
62: Possible risk of impaired fertility
63: Possible risk of harm to the unborn child
Safety Statements: 26-27-45-36/37
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37: Wear suitable protective clothing and gloves
WGK Germany: 3
RTECS: NI8615000
HS Code: 29332990
Poison by subcutaneous route. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. An antithyroid drug. When heated to decomposition it emits very toxic fumes of NO_x and SO_x. See also MERCAPTANS.

Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container.