Reference

Concurrent evaluation of phenacetin, caffeine, antipyrine and aminophenazone by gas chromatography

Concurrent evaluation of phenacetin, caffeine, antipyrine and aminophenazone by gas chromatography. Use of a selective nitrogen/phosphorus detector. Such, V.; Traveset, J.; Farre, M. A.; Gonzalo, R.; Gelpi, E. (Dep. Anal. Control, LACER, S. A., Barcelona, Spain). Cienc. Ind. Farm., 9(10), 268-74 (Spanish) 1977. CODEN: CIDFA8. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Phenacetin (I) [62-44-2], caffeine (II) [58-08-2], antipyrine (III) [60-80-0], and aminophenazone (IV) [58-15-1] were detd. by gas chromatog. using a double flame ionization detector and a selective N-P flame ionization detector. Std. deviation was <1%, except in samples where the I/II ratio was high (e.g. , resp.), in which case the std. deviation for II was 2.59%. Sensitivity for II was 180-fold greater with the N-P flame detector than with the double flame detector. Principal exptl. conditions were: column packing-3% OV-1 on Chromosorb W-HP 80/100 mesh; column, injector, and detector temps.-200°, 250°, and 250°, resp.

Quantitative analysis of pharmaceutical substances by nuclear magnetic resonance spectrometry

Quantitative analysis of pharmaceutical substances by nuclear magnetic resonance spectrometry. I. Pyrazolone derivatives. Ergenc, Nedime; Rollas, Sevim (Eczacilik Fak., Univ. Istanbul, Istanbul, Turk.). Istanbul Univ. Eczacilik Fak. Mecm., 13(1), 38-46 (Turkish) 1977. CODEN: IEFMA9. ISSN: 0367-7524. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) A NMR spectrometric method is described for the rapid quant. detn. of phenazone (I) [60-80-0], aminopyrine (II) [58-15-1], and methampyrone (III) [68-89-3], the solvents being CHCl3 for I and II and AcOH for III.