Reference

Mucosal mast cells

Mucosal mast cells. III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells. Pearce, Frederick L.; Befus, A. Dean; Bienenstock, John (Dep. Chem., Univ. College, London, UK). J. Allergy Clin. Immunol., 73(6), 819-23 (English) 1984. CODEN: JACIBY. ISSN: 0091-6749. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Quercetin [117-39-5], a naturally occurring flavonol structurally related to the antiallergic drug disodium cromoglycate inhibits anaphylactic histamine release from MMC (mucosal mast cells) isolated from the small bowel of rats previously infected with Nippostrongylus brasiliensis. The present effect is immediate and does not decrease on preincubation with the drug. The flavonoids acacetin [480-44-4], apigenin [520-36-5], chrysin [480-40-0] and phloretin [60-82-2] also demonstrate significant activity but are less potent than quercetin. Catechin [154-23-4], flavone [525-82-6], morin [480-16-0], and taxifolin [480-18-2] are inactive. These results resemble those previously reported for the human basophil. In contrast, all compds. with the possible exception of taxifolin demonstrate significant activity against rat PMC (peritoneal mast cells). Acacetin and chrysin are the most effective inhibitors and are more active than quercetin. Rutin [153-18-4] (the glycane of quercetin) and phlorizin [60-81-1] (the glycane of phloretin) are inactive in both systems. These results are discussed in terms of the functional heterogeneity of mast cells from different sources and identify a group of compds. other than doxantrazole (reported previously), which inhibit histamine secretion by MMC.

The influence of secondary plant substances on the growth and development of Myzus persicae of Beijing

The influence of secondary plant substances on the growth and development of Myzus persicae of Beijing. Junde, Qin; Lidao, Ke (Inst. Zool., Acad. Sin., Beijing, Peop. Rep. China). Entomol. Exp. Appl., 35(1), 17-20 (English) 1984. CODEN: ETEAAT. ISSN: 0013-8703. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Section cross-reference(s): 12 Green peach aphids, M. persicae from the Beijing region, maintained on greenhouse tobacco plants, were reared on a modified artificial diet; sinigrin [3952-98-5], tomatine [17406-45-0], nicotine [54-11-5], gossypol [303-45-7], phlorizin [60-81-1], inulin [9005-80-5], and malic acid [6915-15-7] were added sep. in concns. of 0.1 or 0.2%. In preference tests none of the diets enriched by secondary substances was more acceptable than the basal diet. Diet uptake during larval development was detd. quant. by using [14C]glycine in the diets. For the basal diet the total uptake during larval development was ~1.16 mL/aphid. The addn. of secondary plant substances to the diet caused redns. of uptake to different degrees in the order: nicotine > phlorizin > gossypol > tomatine > malic acid > inulin > sinigrin. The larvae feeding on diets contg. sinigrin or tomatine from the 2nd day after birth seemed to have a much higher tolerance for sinigrin than tomatine, with a mortality of 9.6% within 7 days of rearing for the former and 89.4% for the latter. Hence this aphid differs from that occurring in the Netherlands in that the latter has a higher tolerance towards tomatine. The addn. of inulin, malic acid, or sinigrin did not cause a significant difference in the rate of larval development or in adult longevity. Diets contg. these substances could support the aphid's development and reprodn. for 33 generations.