Reference

Changes in superhelical density of closed circular deoxyribonucleic acid by intercalation of anti-R-plasmid drugs and primaquine

Changes in superhelical density of closed circular deoxyribonucleic acid by intercalation of anti-R-plasmid drugs and primaquine. Allison, Richard G.; Hahn, Fred E. (Dep. Mol. Biol., Walter Reed Army Inst. Res., Washington, D. C., USA). Antimicrob. Agents Chemother., 11(2), 251-7 (English) 1977. CODEN: AMACCQ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The following compds., which possess anti-R-plasmid activity in decreasing order, were shown to change systematically the superhelical d. of closed circular PM2 DNA in the manner of intercalators: ethidium bromide [1239-45-8], quinacrine HCl [69-05-6], acridine orange [65-61-2], quinine 2HCl [60-93-5], chlorpromazine [69-09-0], chloroquine diphosphate [50-63-5], and methylene blue [61-73-4]. The same effect was caused by the antimalarial drug primaquine diphosphate [63-45-6], which has not been tested for antiplasmid activity.Except for chemicals metioned above, 65-61-2 and 25535-16-4 are also used. .

The bioavailability of quinine

The bioavailability of quinine. Garnham, J. C.; Raymond, K.; Shotton, E.; Turner, P. (Sch. Pharm., Univ. London, London, Engl.). J. Trop. Med. Hyg., 79(12), 264-9 (English) 1976. CODEN: JTMHA9. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) In vitro dissoln. studies of quinine(I) [130-95-0] frm plain tablets of 3 of its salts suggested a correlation between the soly. of the salts and their dissoln. profiles. I di-HCl [60-93-5] dissolved faster than I bisulfate [549-56-4], which in turn dissolved faster than I sulfate [804-63-7]. Sugar-coated tablets of the salts gave the same trend, but there was a long in vitro lag time for the appearance of I in the dialysis cell used to study the dissoln., due to a delayed disintergration of the tablets. This delay was paralled by a delayed appearance of I in plasma after administration of the coated tablets to persons. The absorption lag time is apparently a function of the formulation and the soly. of the drug. The pharmacokinetics of the plain tablets showed that the di-HCl was the drug of choice because of its rapid appearance in the blood. The com. brand of sugar-coated di-HCl tablets, however, gave low availability when compared with the plain tablets or capsules of the same salt.