Detail of "600-57-7"

Reference

Induction of lysosomal enzyme activities with glucocorticoids during differentiation of cultured mouse myeloid leukemia cells

Induction of lysosomal enzyme activities with glucocorticoids during differentiation of cultured mouse myeloid leukemia cells. Kasukabe, Takashi; Honma, Yoshio; Hozumi, Motoo (Dep. Chemother., Saitama Cancer Cent. Res. Inst., Saitama, Japan). Gann, 68(6), 765-73 (English) 1977. CODEN: GANNA2. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) The activities of the lysosomal enzymes, lysozyme [9001-63-2], acid protease [9001-92-7], and b-glucuronidase [9001-45-0] were induced with glucocorticoids during differentiation of cultured mouse myeloid leukemia line cells (M1). The induction of lysozyme activity accompanied by phagocytosis in M1 cells was very pronounced. Although lysozyme activity was not detected in undifferentiated cells, it showed a marked increase from the second day of incubation of M1 cells with dexamethasone (I) [50-02-2]. On the 5th day of incubation, the activity was about 1/2 that of mouse peritoneal macrophages. There was competitive interaction among different steroids on induction of lysozyme activity in M1 cells. 11b-Hydroxyprogesterone [600-57-7] and 11-deoxycortisol [152-58-9] did not induce the max. level of the activity, and cortisone [53-06-5] and fluoxymesterone [76-43-7] were not active in inducing the enzyme activity. However, these steroids inhibited the induction of enzyme activity with I prednisolone [50-24-8], or hydrocortisone [50-23-7]. Induction of lysozyme activity and phagocytic activity of M1 cells with I was inhibited by 5-bromodeoxyuridine or puromycin at a concn. that did not interfere with the growth of cells. Differentiation was not induced in DR-6 cells isolated from M1 cells even in a high concn. of I. Neither lysozyme activity nor other lysosomal enzyme activities were induced in DR-6 cells with I. Apparently, glucocorticoids are capable of inducing some lysosomal enzyme activities as well as morphol. and functional differentiation in M1 cells, and among these enzymes, lysozyme activity is a fairly suitable biochem. marker for the differentiation of M1 cells.

Altered blood levels of corticosteroids in the rat after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Altered blood levels of corticosteroids in the rat after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Balk, James L.; Piper, Walter N. (Coll. Med., Univ. Nebraska, Omaha, NE 68105, USA). Biochem. Pharmacol., 33(15), 2531-4 (English) 1984. CODEN: BCPCA6. ISSN: 0006-2952. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Blood levels of corticosterone [50-22-6] in the rat were significantly lower (26-29% of control) than those of control 14 and 21 days after oral administration of 25 mg/kg of TCDD (I) [1746-01-6]. 11-b-Hydroxyprogesterone [600-57-7] was isolated from blood samples indicating that TCDD produced a block in the 21-hydroxylase step.