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Detail of "60282-87-3"

  • CAS Number:
  • 60282-87-3
  • Name:

  • Gestodene

  • Molecular Structure:
  • Formula:
  • C21H26O2
  • Molecular Weight:
  • 310.43
  • Synonyms:
  • Gestinol;13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregna-4,15-dien-20-yn-3-one;SHB 331;18,19-Dinorpregna-4,15-dien-20-yn-3-one,13-ethyl-17-hydroxy-, (17a)-;7-alpha-Ethinyl-13-ethyl-17-beta-hydroxy-4,15-gonadien-3-one ; Gestodeno;
  • EINECS:
  • 262-145-8
  • Density:
  • 1.15 g/cm3
  • Melting Point:
  • 190-192 °C
  • Boiling Point:
  • 462.7 °C at 760 mmHg
  • Flash Point:
  • 196.9 °C
  • Appearance:
  • white crystalline solid
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CAS No.60282-87-3 GestodeneCompetitive Product

Gestodene is a progestogen hormonal contraceptive, side effects caused by the medication include : antinuclear antibody positive, arthralgia, monarthritis.

Supplier:SOGA ENTERPRISES ASIA GROUP [ China (Mainland)]

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CAS No.60282-87-3 GestodeneCompetitive Product

Gestodene USP28/EP5.0

Supplier:Sinosource Pharma Limited [ China (Mainland)]

Silver
Supplier 920Integral
920

Tel:0086-20-23345203

Address:1-19L, Canada Garden, Tianhe, Guangzhou,China

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CAS No.60282-87-3 GestodeneCompetitive Product

Supplier:Synchem Pharma Co.,Ltd [ China (Mainland)]

Platinum
Supplier 1042Integral
1042

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CAS No.60282-87-3 Gestodene

Supplier:Taizhou Crene Biotechnology co.ltd [ China (Mainland)]

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1090

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Address:Economic Developed Zone of Taizhou Zhejiang China

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CAS No.60282-87-3 Gestodene

Assay:99%  Appearance:powder  Package:25kg/drum

Supplier:HANGZHOU TOYOND BIOTECH CO., LTD [ China (Mainland)]

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SupplierHALALISOKOSHER 1590Integral
1590

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CAS No.60282-87-3 Gestodene

  Package:1Mg;5Mg;10Mg...Storage:store in RT  Transportation:by air/sea  Application:Gestodene

Supplier:SHAANXI TOP PHARM CHEMICAL CO.LTD [ China (Mainland)]

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Supplier 370Integral
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CAS No.60282-87-3 Gestodene

Assay:≥99%(HPLC)  Appearance:Inqury  Package:1G,5G,121G

Supplier:Shanghai DEMO Medical Tech Co.,Ltd [ China (Mainland)]

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1269

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CAS No.60282-87-3 Gestodene

Assay:98%  Appearance:White powder

Supplier:Taiyuan RHF CO., ltd. [ China (Mainland)]

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2160

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CAS No.60282-87-3 Gestodene

60282-87-3

Supplier:Jinan Wedo Industrial Co., Ltd. [ China (Mainland)]

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CAS No.60282-87-3 Gestodene

Gestodene

Supplier:TCS INDUSTRY LIMITED [ China (Mainland)]

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CAS No.60282-87-3 Gestodene

Gestodene

Supplier:Josun International Limited [ China (Mainland)]

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Address:No.50, Zhaiying Street, Shijaizhuang,Hebei,China

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CAS No.60282-87-3 Gestodene

Assay:98%

Supplier:Hangzhou Dayangchem Co., Ltd. [ China (Mainland)]

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3875

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Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China

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CAS No.60282-87-3 Gestodene

Supplier:LIDE PHARMACEUTICALS LIMITED [ China (Mainland)]

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Supplier 965Integral
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Tel:+86-25-58409506; +86-25-58766653

Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.

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CAS No.60282-87-3 Gestodene

Supplier:Jinan Haohua Industry CO., LTD [ China (Mainland)]

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CAS No.60282-87-3 Gestodene

Supplier:ChemOrganic Limited [ China (Mainland)]

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Address:Room 608,Building B , Zhejiang University science park, #525 Xixi Road ,hangzhou,China.

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CAS No.60282-87-3 Gestodene

Supplier:Zhejiang Chemline International Co., Ltd. [ China (Mainland)]

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Address:Hengdian Industry Area, Dongyang, Zhejiang, China

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CAS No.60282-87-3 Gestodene

Supplier:Afine Chemicals Limited [ China (Mainland)]

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CAS No.60282-87-3 Gestodene

Supplier:Reath Bioscience Co., Inc [ China (Mainland)]

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CAS No.60282-87-3 Gestodene

Supplier:Shanghai Rainbow Chemistry Co., Ltd. [ China (Mainland)]

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Address:5th floor, Building A, No. 10, Lane 1305, Huajing Road, Xuhui Area, Shanghai

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CAS No.60282-87-3 Gestodene

Supplier:Tiantai Linda Import & Export Co., Ltd. [ China (Mainland)]

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Address:Suite C.702, AnShaMingZhu Building, Tiantai County, Zhejiang,

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CAS No.60282-87-3 Gestodene

Supplier:Changzhou Highassay Chemical Co., Ltd [ China (Mainland)]

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Address:XIXIASHU TOWN, XINBEI DISTRICT, CHANGZHOU, JIANGSU

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CAS No.60282-87-3 Gestodene

Supplier:HONGKONG CHEMAPI LIMITED [ Hong Kong]

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1430

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Address:1-5-402,Caiyangli,Hongxing road,Hedong district

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CAS No.60282-87-3 Gestodene

Assay:≥98.0%

Supplier:TAIZHOU SHASIN PHARMACHEM CO.,LTD [ China (Mainland)]

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Supplier 1370Integral
1370

Tel:0086-576-88525005, 88880039

Address:B Area. 10 Floor.Yaodadasha. 289#.Shifu Road.Taizhou.Zhejiang.China

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CAS No.60282-87-3 Gestodene

Supplier:LCN BIO-CHEMICALS CO., LIMITED [ China (Mainland)]

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910

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Address:No.55, West GuangYuan Road

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CAS No.60282-87-3 Gestodene

Gestodene

Supplier:Hangzhou Starshine Pharmaceutical Co., LTD [ China (Mainland)]

660Integral
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Address:NO.508 WENSAN ROAD, HANGZHOU, CHINA.

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CAS No.60282-87-3 Gestodene

Assay:99%  Appearance:white crysta...  Package:1 kg in a al...

CAS No. 60282-87-3 Other Names Gestodene EINECS No. 262-145-8 Place of Origin China (Mainland) Type Auxiliaries and Other Medicinal Chemicals Grade Standard Medicine Grade Brand Name Xingren Purity 99% Hormone

Min. Order:1Kilogram

Supplier:Zhengzhou Xingren Chemical Products Co.,Ltd. [ China (Mainland)]

80Integral
80

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Address:Room1101，Unit1，Building3，No.39 Zhengtong Road,Zhengzhou,Henan

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CAS No.60282-87-3 Gestodene

  Appearance:creamy white...  Application:Resistance p...

EP7. Chemical name: (17alpha)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,15-dien-20-yn -3-one. Contraceptive Drugs belong to progestational hormone

Min. Order:100Gram

Supplier:hangzhou deli chemical co., [ China (Mainland)]

144Integral
144

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Address:tang xi industry area, yuhang district, hangzhou

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CAS No.60282-87-3 Gestodene

Gestodene

Supplier:Tianjin HongShengLi Chemical Co.,Ltd. [ China (Mainland)]

900Integral
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Address:No.188 Yongan Road,Hexi District,Tianjin,China

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CAS No.60282-87-3 Gestodene

Product name: Gestodone, This is one of our strong products.

Supplier:orichem international ltd [ China (Mainland)]

685Integral
685

Tel:0571-85270505-112

Address:Flat E 16/F 1 Huazhe Plaza,Hangzhou,China

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CAS No.60282-87-3 Gestodene

Gestodene is a progestogen hormonal contraceptive.

Supplier:Selleck Chemicals [ United States]

600Integral
600

Tel:+18325828158

Address:2626 South Loop West, Suite 225, Houston, TX 77054 USA

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CAS No.60282-87-3 Gestodene

IN HOUSE STANDARD

Supplier:Agile Mfg. Chemical Co., Ltd. [ China (Mainland)]

32Integral
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Address:7th Quarter, High-tech Industrial Development Zone, Qingyuan, Guangdong, China

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CAS No.60282-87-3 Gestodene

Supplier:Lanza Pharma Ltda. [ Brazil]

600Integral
600

Tel:+ 55 11 5533-2181

Address:Chácaras Marco - Barueri - SP, Brazil

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CAS No.60282-87-3 Gestodene

Supplier:Euticals [ Italy]

600Integral
600

Tel:+39 02 96953398

Address:Origgio

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Reference

Plasma levels of levonorgestrel, gestodene, norethisterone and cyproterone acetate on single-dose subcutaneous administration in oily solution in the rat, beagel and rhesus monkey
Plasma levels of levonorgestrel, gestodene, norethisterone and cyproterone acetate on single-dose subcutaneous administration in oily solution in the rat, beagel and rhesus monkey. Duesterberg, B. (Dep. Pharmacokinet., Schering A.-G. Berlin/Bergkamen, Berlin 1000/65, Fed. Rep. Ger.). Steroids, 43(1), 43-56 (English) 1984. CODEN: STEDAM. ISSN: 0039-128X. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 2 The pharmacokinetics of levonorgestrel [797-63-7], gestodene [60282-87-3], norethisterone [68-22-4] and cyproterone acetate [427-51-0] are described in the title species following s.c. administration in oily soln. Half-lives calcd. for the disposition of each metabolically unchanged drug in plasma revealed marked differences with respect to animal species. A comparison of the different progestogens showed large variations in this parameter in all the animal species. Apparently, there are physicochem. properties as well as metabolic rate limitations affecting the release and elimination of synthetic progestogens administered in oily solns. The results are compared with the half-lives of these progestogens administered i.v. as reported previously. A prolongation of half-life as a result of the depot effect of s.c. administration was demonstrated for all the progestogens in the title animals.
Progestogens with antimineralocorticoid activity
Progestogens with antimineralocorticoid activity. Losert, W.; Casals-Stenzel, J.; Buse, M. (Res. Lab., Schering A.-G., Berlin D-1000/65, Fed. Rep. Ger.). Arzneim.-Forsch., 35(2), 459-71 (English) 1985. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Eleven progestogenic steroids were tested for their ability to inhibit the renal actions of aldosterone in rats. Gestodene [60282-87-3] (26.7 or 53.3 mg/kg, s.c.), progesterone [57-83-0] (53.3 mg/kg, s.c.), spironolactone [52-01-7] (26.7 mg/kg, s.c.), spirorenone [74220-07-8] (13.3 mg/kg, s.c.), 1,2-dihydrospirorenone [67392-87-4] (13.3 mg/kg, s.c.), and 1,2a-methylene-spirotenone [95218-20-5] (13.3 mg/kg, s.c.) all exhibited marked antimineralocorticosteroid activity. Canrenone [976-71-6] (53.3 mg/kg, s.c.) had weak activity, whereas d-norgestrel [6533-00-2], norethisterone acetate [51-98-9], 3-keto-desogestrel [54048-10-1], and cyproterone acetate [427-51-0] were inactive in this test. With the exception of progesterone, the antimineralocorticosteroid activity of the steroids tested was also demonstrated after oral administration. The potencies, relative to spironolactone, were: gestodene, ~0.2; canrenone, ~0.3-0.35; spirorenone, 7-8; 1,2-dihydrospirorenone, ~8; 1,2a-methylene-spirorenone, ~3.5. Gestodene may be regarded as the 1st progestogen of the nortestosterone series exhibiting a more natural, progestogen-like activity; however, its low antimineralocorticosteroid potency precludes its therapeutic usefulness in man. In contrast, 1,2-dihydrospirorenone exhibit progestogenic and antimineralocorticosteroid activity in the same dose range and may be the prototype of a new class of orally active progestogens with progesterone-like effects on salt and water excretion.
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