Detail of "6029-87-4"

CAS Number:
6029-87-4
Name:
2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione,4,5,8,10,12,13,13a,13b-octahydro-4-hydroxy-3,4,5-trimethyl-,(3R,4S,5S,13aR,13bR)- (9CI)
Molecular Structure:
Formula:
C16H23 N O5
Molecular Weight:
309.40
Synonyms:
20-Norcrotalanan-11,15-dione,14,19-dihydro-13-hydroxy-, (13a,14a)-; Fulvine (7CI,8CI);13-Epicrispatine;2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione,4,5,8,10,12,13,13a,13b-octahydro-4-hydroxy-3,4,5-trimethyl-,[3R-(3R*,4S*,5S*,13aR*,13bR*)]-; NSC 89932
Safety:
Poison by intraperitoneal route. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. Details

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Activation of monocrotaline, fulvine and their derivatives to toxic pyrroles by some thiols: Activation of monocrotaline, fulvine and their derivatives to toxic pyrroles by some thiols. Juneja, T. R.; Gupta, R. L.; Samanta, Subir (Dep. Pharm. Sci., Panjab Univ., Chandigarh 160014, India). Toxicol. Lett., 21(2), 185-9 (English) 1984. CODEN: TOLED5. ISSN: 0378-4274. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Arythiols (thiophenol [108-98-5], p-thiocresol [106-45-6], 6-mercaptopurine [50-44-2], and benzylmercaptan [100-53-8]) dehydrogenated monocrotaline (I) [315-22-0], fulvine (II) [6029-87-4], I N-oxide [35337-98-5], II N-oxide [19786-16-4], and retronecine [480-85-3] to activated pyrrole derivs. Unlike arylthiols, allkylthiols (butylmercaptan [109-79-5], hexylmercaptan [111-31-9], and 2-mercaptoethanol [60-24-2]), cysteine [52-90-4], and GSH [70-18-8] failed to dehydrogenate. All thiols failed to dehydrogenate methiodides of I and II or in an alk. medium. Therefore, if arylthiols are present in the body through industrial exposure or drug intake, they could convert pyrrolizidine alkaloids nonenzymically to activated pyrroles and enhance their toxicity.