Detail of "603-00-9"

Reference

Interpretation of dissolution rate data from in vitro testing of compressed tablets

Interpretation of dissolution rate data from in vitro testing of compressed tablets. Kitazawa, Shikifumi; Johno, Ikuo; Minouchi, Tokuzo; Okada, Jutaro (Dep. Pharm., Kyoto Univ. Hosp., Kyoto, Japan). J. Pharm. Pharmacol., 29(8), 453-9 (English) 1977. CODEN: JPPMAB. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Dissoln. tests on uncoated caffeine [58-08-2], aspirin [50-78-2], and proxyphylline [603-00-9] tablets using 2 dissoln. methods gave similar dissoln. rate consts. Consideration of changes in surface area of drug available for dissoln. may not always be necessary for detn. of dissoln. rate. The lnW.infin./(W.infin.-W) versus time plot (where W.infin. is the amt. of drug dissolved at infinite time and W is the amt. dissolved at time t) devised by S. Kitazawa et al. (1975) may be a useful and simple way of obtaining the dissoln. rate const. of an active ingredient from a dosage form such as compressed tablets.

Antiglaucoma ophthalmic solutions containing tetraazabicyclic compounds

Antiglaucoma ophthalmic solutions containing tetraazabicyclic compounds. Horlington, Michael (Smith and Nephew Associated Co. Ltd., UK). U.S. US 4425346 A 10 Jan 1984, 10 pp. Cont.-in-part of U.S. Ser. No. 287,356. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-505; A61K031-52. NCL: 424253000. APPLICATION: US 82-342655 25 Jan 1982. PRIORITY: GB 81-3917 9 Feb 1981; GB 81-8537 18 Mar 1981; US 81-287356 27 Jul 1981. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Sterile, nonirritant, nontoxic compns. for topical application to the eye for the treatment of glaucoma are prepd. contg. tetraazabicyclo compds. Thus, an aq. suspension which lowered ocular tension in the eye without changing the pupil diam. was prepd. 9005-63-4 and 1476-48-8 which are cas registry numbers are also used here. contg. 0.5% 2,4,7-triamino-6-(2-bromophenyl)pteridine (I) [13510-74-2] and 50% poly(vinylpyrrolidone) [9003-39-8] in 100 mL H2O. The ophthalmic compns. may also contain suspending agents, e.g., hydroxyethyl cellulose [9004-62-0], surfactants, e.g. polyoxypropylene-polyoxyethylene copolymer [9003-11-6], solubilizing agents, e.g., proxyphylline [603-00-9] or diphylline [479-18-5], and a preservative, e.g., benzalkonium chloride. The effectiveness of a no. of tetraazabicyclic compds. was demonstrated on the ocular tension in rabbits' eyes by topical administration of solns. or suspensions of the compds. A 0.02% soln. of 2,4,7-triamino-6-(4-methylphenyl)pteridine [2853-71-6] contg. 6.0% dyphylline as solubilizer caused a lowering of intraocular pressure for a longer duration than did a suspension contg. 0.8% hydroxyethyl cellulose as suspending agent. .