Reference

Aminophthalimides

Aminophthalimides. Mueller, Wolfgang; Loeffler, Ralph; Hepp, Wulfdieter; Kleine, Fritz; Merkel, Dieter; Schumann, Siegfried (VEB Chemiekombinat Bitterfeld, Ger. Dem. Rep.). Ger. (East) DD 239790 A1 8 Oct 1986, 3 pp. (German Democratic Republic) CODEN: GEXXA8. CLASS: ICM: C07D209-48. APPLICATION: DD 85-279265 2 Aug 1985. DOCUMENT TYPE: Patent CA Section: 41 (Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers) Section cross-reference(s): 27 Aminophthalimides I (R = H, Cl, Br; R1 = H, Me, Et, Pr), useful in the manuf. of azo dyes, are prepd. by redn. of the corresponding nitrophthalimides in the presence of aq. NaSH.2H2O suspension at 10-50° and pH 8.2-9.8. 4-Nitrophthalimide was added to water contg. a dispersing agent, the suspension stirred, 23% aq. NaSH soln. added, and 15% aq. HCl soln. added to maintain pH at 8.2-9.5. The redn. temp. was 20-35°. After completion of nitro compd. addn. the mixt. was stirred for an addnl. 30 min, the solid product filtered off, washed neutral, and dissolved at 30° in a soln. 41663-84-7 and 603-62-3 which are cas registry numbers of substances are two of reagents here. of ZnCl2.H2O in concd. HCl. A 59.8% 4-aminophthalimide was obtained in 82.3% theor. yield. .

2-Pyrrolidinylideneureas, a new class of central nervous system agents

2-Pyrrolidinylideneureas, a new class of central nervous system agents. Rasmussen, C. R.; Gardocki, Joseph F.; Plampin, James N.; Twardzik, Barbara L.; Reynolds, Brian E.; Molinari, Albert J.; Schwartz, Norman; Bennetts, Walter W.; Price, Beth E.; Marakowski, Janis (Dep. Chem. Res., McNeil Lab., Fort Washington, Pa., USA). J. Med. Chem., 21(10), 1044-54 (English) 1978. CODEN: JMCMAR. 603-62-3 is also in the experiment. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 27 Pyrrolidinylideneureas (I) were prepd. and screened for pharmacol. activity. I (X = H, 4-NO2, 3-Br, 3-F, 3-Cl, 3-Me) had anxiolytic activity. I 2,6-disubstituted with Me, Cl, and Br imparted potent muscle-relaxant properties which appear to be centrally mediated. A significant sepn. of the anxiolytic and muscle-relaxant properties fromother CNS activities, eg, anticonvulsant, sedative, and hypnotic, was achieved. I were prepd. by treating 2-imino-1-methylpyrrolidines with aryl isocyanates. .