Detail of "60325-46-4"

Reference

A tissue-selective prostaglandin E2 analog with potent antifertility effects

A tissue-selective prostaglandin E2 analog with potent antifertility effects. Hess, H. J.; Bindra, J. S.; Constantine, J. W.; Elger, W.; Loge, O.; Schillinger, E.; Losert, W. (Cent. Res., Pfizer Inc., Groton, Conn., USA). Experientia, 33(8), 1076-7 (English) 1977. CODEN: EXPEAM. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) In guinea pigs, rats, and monkeys, the abortifacient potency of CP 34089 (I) [60325-46-4] was .gtoreq.10-fold more potent than PGE2 (II) [363-24-6]. In vitro, both I and II had the same potency in causing isotonic contractions of the isolated estrus uterus. The bronchodilating, vasodilating, and in vitro guinea pig ileum-contracting potency of I was considerably less than that of II. Thus, I may have a greater abortifacient activity and enhanced tissue selectivity when compared to II.

Plasma renin activity and cAMP in termination of pregnancy induced by sulprostone

Plasma renin activity and cAMP in termination of pregnancy induced by sulprostone. Saarikoski, Seppo; Saastamoinen, Jukka; Penttila, Ilkka; Castren, Olli (Cent. Hosp. Kuopio, Univ. Kuopio, Kuopio SF-70210, Finland). Br. J. Obstet. Gynaecol., 94(4), 328-32 (English) 1987. CODEN: BJOGAS. ISSN: 0306-5456. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Plasma renin [9015-94-5] activity (PRA), plasma concns. of cAMP [60-92-4], and the serum levels of estradiol [50-28-2], progesterone [57-83-0], chorionic gonadotropin [9002-61-3], K, Na, and Ca were estd. in connection with termination of pregnancy in women by sulprostone [60325-46-4], a deriv. of PGE2. 9002-61-3 and 7440-09-7 which are cas registry numbers are also used here. A rapid decrease in PRA was obsd. during and after infusion of 1000 or 1500 mg sulprostone. PRA returned to the initial values at 24 h after drug administration. The lowest levels of PRA were 36% and 51% of the initial values in the 2 drug concn. groups. No changes were obsd. in the control group. The value for plasma cAMP did not correspond completely to the changes in PRA. Serum concns. of estradiol, progesterone, and chorionic gonadotropin showed gradual decreases during drug administration. The changes in serum K, Na, and Ca were minimal. The decrease in PRA assocd. with sulprostone is very surprising. These findings elucidate, in part, the still rather poorly known mechanisms and function of the renin-angiotensin system in pregnancy. .