Detail of "6033-32-5"

Reference

Bicyclic lactams

Bicyclic lactams. Harris, Elbert E.; Patchett, Arthur A.Several substances are used for example 6033-32-5 and 89461-22-3 which are their cas registry numbers.; Tristram, Edward W.; Thorsett, Eugene D.; Wyvratt, Matthew J., Jr. (Merck and Co., Inc. , USA). U.S. US 4415496 A 15 Nov 1983, 25 pp. Cont.-in-part of U.S. Ser. No. 246,492, abandoned. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C07D513-04. NCL: 260239300B. APPLICATION: US 82-348811 19 Feb 1982. PRIORITY: US 81-246492 23 Mar 1981. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 27, 34, 63 Antihypertensive (no data) thiazoloazepinecarboxylates I [R, R2 = H, alkyl, aryl, aralkyl; R1 = H, alkenyl, alkynyl, (un)substituted alkyl, cycloalkyl, aryl] were prepd. Thus, (S)-2-amino-6-hydroxyhexanoic acid was treated with N-(ethoxycarbonyl)phthalimide to give (S)-6-hydroxy-2-phthalimidohexanoic acid. This was oxidized to the formyl deriv. and cyclocondensed with L-cysteine Me ester to give thiazolidine (4R)-II, which was cyclized to give epimeric thiazoloazepines III (R3 = phthalimido). (9Ab)-III was hydrolyzed to the free amine, sapond., and condensed with PhCH2CH2COCO2Me to give diasteromeric aminobutyrates IV (R4 = Me), which were sapond. to give the free acids IV (R4 = H). .

Analysis of non-protein amino acids as specific markers of low density lipoprotein apolipoprotein B-100 oxidation in human atherosclerotic lesions: the use of N(O)-ethoxycarbonyl trifluoroethyl ester derivatives and GC-MS

Analysis of non-protein amino acids as specific markers of low density lipoprotein apolipoprotein B-100 oxidation in human atherosclerotic lesions: the use of N(O)-ethoxycarbonyl trifluoroethyl ester derivatives and GC-MS. Pietzsch, Jens; Bergmann, Ralf; Kopprasch, Steffi (Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf Dresden, Dresden D-01314, Germany). Spectroscopy (Amsterdam, Netherlands), 18(2), 177-183 (English) 2004 IOS Press. CODEN: SPIJDZ. ISSN: 0712-4813. DOCUMENT TYPE: Journal CA Section: 9 (Biochemical Methods) Section cross-reference(s): 13 Oxidative modification of proteins can interfere with crit. cellular functions, and is widely regarded as a crucial event in the pathogenesis of various diseases ranging from rheumatoid arthritis to atherosclerosis and cancer. In this line, a new GC-MS methodol. using N(O)-ethoxycarbonyl trifluoroethyl amino acid esters (ECEE-F3) for rapid and sensitive detn. of 3-chlorotyrosine, 5-hydroxy-2-aminovaleric acid (HAVA), and 6-hydroxy-2-aminocaproic acid (HACA) in proteins has been developed. 3-Chlorotyrosine is a highly specific marker of myeloperoxidase catalyzed protein oxidn., whereas g-glutamyl semialdehyde (gGSA) and a-aminoadipyl semialdehyde (aASA), which by redn. form HAVA and HACA, resp., are specifically formed by metal catalyzed oxidn.In this article, certain chemicals are used. Some of their cas registry numbers are 6033-32-5 and 6152-89-2 processes. ECEE-F3 derivs. are formed by the unlabored reaction of amino acids with ethylchloroformate plus trifluoroethanol plus pyridine. The key steps of the methodol. employed are (i) enzymic hydrolysis of target proteins to prevent decompn. of oxidn. products during hydrolysis and (ii) an uniquely rapid derivatization of amino acids completing sample prepn. for GC within a few minutes in aq. soln. at room temp. The use of these stable products of protein amino acid side chain oxidn. as potential markers for assessing oxidative damage in LDL apoB-100 recovered from human aortic vascular lesions is demonstrated. These observations provide quant. chem. evidence for metal catalyzed oxidative processes in the human artery wall. .