Detail of "6064-63-7"

Reference

Effect of 2-hydroxyacids on guinea pig footpad stratum corneum: mechanical properties and binding studies

Effect of 2-hydroxyacids on guinea pig footpad stratum corneum: mechanical properties and binding studies. Alderson, Susan G.; Barratt, Martin D.; Black, J. Gordon (Environ. Saf. Lab., Unilever Res., Sharnbrook/Bedford MK44 1LQ, UK). Int. J. Cosmet. Sci., 6(2), 91-100 (English) 1984. CODEN: IJCMDW. ISSN: 0142-5463. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) The effect of aq. solns. of C3-10 2-hydroxy acids on the extensibility of undamaged and solvent-damaged guinea-pig footpad stratum corneum was studied. The increase in extensibility of solvent-damaged corneum, caused by treatment with hydroxy acid, reached a max. with 2-hydroxycaprylic acid (I) [617-73-2] on undamaged corneum; I was the only hydroxy acid to give a significant effect. The increase in corneum extensibility produced by 2-hydroxy acids decreases when the pH is increased from 3 to 4. This loss of effect correlates with the ionization of the hydroxy acid (pK u 3.85). The binding of radiolabeled 2-hydroxycaproic acid [6064-63-7] and I stratum corneum was studied. I binds much more strongly than 2-hydroxycaproic acid, the difference in the binding being consistent with the hydrophobic binding energy of 2 CH2 groups. Increasing the pH above 3.5 results in a large decrease in the binding of I in line with the corresponding redn. in extensibility. Treatment with 2-hydroxy acids results in a small increase in the water-binding capacity of solvent-damaged stratum corneum, but in a decrease in the water-binding capacity of undamaged stratum corneum. These data are discussed in terms of a possible mechanism for the plasticizing of stratum corneum.

Detection of metabolites by frequency-pulsed electron capture gas-liquid chromatography in serum and cerebrospinal fluid of a patient with Nocardia infection

Detection of metabolites by frequency-pulsed electron capture gas-liquid chromatography in serum and cerebrospinal fluid of a patient with Nocardia infection. Brooks, J. B.; Kasin, J. V.; Fast, D. M.; Daneshvar, Maryam I. (Anal. Chem. Lab., Cent. Dis. Control, Atlanta, GA 30333, USA). J. Clin. Microbiol., 25(2), 445-8 (English) 1987. CODEN: JCMIDW. ISSN: 0095-1137. DOCUMENT TYPE: Journal CA Section: 9 (Biochemical Methods) Section cross-reference(s): 10, 14 Serum (SR) and cerebrospinal fluid (CSF) from a patient suspected of having tuberculous meningitis were submitted for anal. by frequency-pulsed electron capture gas-liq. chromatog. (FPEC GLC). The samples were tested for the presence of carboxylic acids, alcs. 6064-63-7 and 617-31-2 which are cas registry numbers of substances are two of reagents here., hydroxy acids, and amines by methods described previously. The results were different from previous FPEC GLC profiles of SR and CSF from patients with known tuberculous meningitis. Both the SR and CSF contained several unidentified compds. that were not previously detected in tuberculous meningitis or any of our other studies of body fluids. Nocardia brasiliensis Was later isolated from the patient. Detection of these metabolites by FPEC GLC could prove to be useful for rapid diagnosis of Nocardia disease, and their identification will provide a better understanding of metabolites produced by Nocardia in vivo. .