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CAS No.: | 60643-86-9 |
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Name: | Vigabatrin |
Article Data: | 9 |
Molecular Structure: | |
Formula: | C6H11NO2 |
Molecular Weight: | 129.159 |
Synonyms: | Vigabatrin |
EINECS: | 200-659-6 |
Density: | 1.108?g/mL?at 25?°C(lit.) |
Melting Point: | 209° |
Boiling Point: | 73?°C749?mm Hg(lit.) |
Flash Point: | 9℃ |
Hazard Symbols: | R36/37/38:; |
Risk Codes: | Xi:Irritant; "> Xi:Irritant; |
Safety: | 26-36-45-36/37-16-7 |
PSA: | 63.32000 |
LogP: | 1.06480 |
5(S)-Vinyl-2-Pyrrolidinone
4-amino-5-hexenoic acid
Conditions | Yield |
---|---|
Stage #1: 5(S)-Vinyl-2-Pyrrolidinone With potassium hydroxide In water for 2h; Reflux; Stage #2: With acetic acid In water; isopropyl alcohol at 0 - 30℃; for 4.5h; | 74% |
Stage #1: 5(S)-Vinyl-2-Pyrrolidinone With water; potassium hydroxide In isopropyl alcohol at 20 - 60℃; for 16h; Inert atmosphere; Stage #2: With acetic acid In water; isopropyl alcohol | 60% |
With water; potassium hydroxide at 90 - 100℃; for 3h; Reflux; |
4-benzenesulphonamido 5-hexenoic acid
4-amino-5-hexenoic acid
Conditions | Yield |
---|---|
With ammonia; sodium In tetrahydrofuran | 63% |
4-amino-5-hexenoic acid
Conditions | Yield |
---|---|
With ammonium hydroxide; Dowex H(+) |
4-(carbobenzyloxy)amino-5-hexenenitrile
4-amino-5-hexenoic acid
Conditions | Yield |
---|---|
With diclazuril In water-d2 at 100℃; |
5-bromo-3-(carbobenzyloxy)amino-1-pentene
4-amino-5-hexenoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / tetrahydrofuran / 2 h / Heating 2: DCl / D2O / 100 °C View Scheme |
3-(carbobenzyloxy)amino-4-penten-1-ol
4-amino-5-hexenoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 89 percent / PPh3; CBr4 / CH2Cl2 / 1 h / 0 °C 2: 70 percent / tetrahydrofuran / 2 h / Heating 3: DCl / D2O / 100 °C View Scheme |
(E)-6-hydroxy-hex-4-enoic acid ethyl ester
4-amino-5-hexenoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) NaH / 1.) ether, 0 deg C, 1 h; 2.) xylene, 48 h, reflux 2: 6N HCl / 12 h / Heating 3: Dowex H(+), 1N NH4OH View Scheme |
4-amino-5-hexenoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: HCl gas / ethanol 2: 1.) NaH / 1.) ether, 0 deg C, 1 h; 2.) xylene, 48 h, reflux 3: 6N HCl / 12 h / Heating 4: Dowex H(+), 1N NH4OH View Scheme |
4-(2,2,2-Trichloro-acetylamino)-hex-5-enoic acid ethyl ester
4-amino-5-hexenoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 6N HCl / 12 h / Heating 2: Dowex H(+), 1N NH4OH View Scheme |
ethyl hex-5-enoate
4-amino-5-hexenoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 75 percent / diethyl ether / 40 h / Ambient temperature 2: 1.) hexamethyldisilazane, 2.) 0.2 N NaOH / 1.) dichloromethane, reflux, 24 h, 2.) 48 h 3: 72 percent / potassium hydroxide / H2O / 2 h / 100 °C 4: 63 percent / sodium, liquid ammonia / tetrahydrofuran View Scheme |