Detail of "60645-01-4"
- CAS Number:
- 60645-01-4
- Name:
R 32767
- Molecular Structure:
- Formula:
- C25H30N2O3
R 32767
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Reference
- Crystal structures and structure-activity relationships of the 4-substituted fentanyl derivatives
- Crystal structures and structure-activity relationships of the 4-substituted fentanyl derivatives. Hu, Jianguo; Li, Yulin; Chen, Jisheng (PLA Inst. Pharm. Chem.Several substances like 60645-01-4 may be metioned in this study., Beijing, Peop. Rep. China). Yaoxue Xuebao, 22(11), 864-8 (Chinese) 1987. CODEN: YHHPAL. ISSN: 0513-4870. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 22, 75 Crystal structures are reported for the fentanyl derivs. R 32767 (I, R1 = CO2Me; R2 = cyclopropyl; X = CH:CH) and R 32557 (I, R1 = CO2Me; R2 = Et; X = CH:CH). These structures are compared with 3 other I (R1 = CH2OMe, H; R2 = Et; X = CH:CH, S). Toxicity is considered to be related to the angles between the 2 arom. rings and the piperidine ring. Analgesic activity corresponds to a torsion angle of S120° at C(14)-C(1)-N(2)-C(19) (based on the locants of R 32557). .