Reference

Respiratory gas exchange as an indicator of changed radioresistance in mammals

Respiratory gas exchange as an indicator of changed radioresistance in mammals. Novak, L.; Misustova, J. (Inst. Biophys., Czech. Acad. Sci., Brno, Czech.). Life Sci. Space Res.Several substances with their cas registry numbers 50-67-9 and 51-85-4 may be metioned in this study., 12, 125-8 (English) 1974. CODEN: LSSRAG. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8 5-Methoxytryptamine [608-07-1] (25 mg/kg), serotonin (I) [50-67-9] (50 mg/kg), cystamine [51-85-4] (200 mg/kg), and AET [56-10-0] (200 mg/kg) injected i.p. into mice showed radioprotective effects against x-irradn., and this protection was correlated with the decrease in respiratory gas exchange which was expressed by the O consumption. The correlation is used to evaluate quant. the radioprotective activity of these compds. .

Calcium-dependency of the pressor responses to selective 5-hydroxytryptamine receptor agonists in pithed rats

Calcium-dependency of the pressor responses to selective 5-hydroxytryptamine receptor agonists in pithed rats. Kalkman, H. O.; Boddeke, H. W. G. M.; Timmermans, P. B. M. W. M.; Van Zwieten, P. A. (Dep. Pharm., Univ. Amsterdam, Amsterdam 1018 TV, Neth.). J. Auton. Pharmacol., 3(4), 281-6 (English) 1983. CODEN: JAPHDU. ISSN: 0144-1795. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The pressor responses to 6 selective 5-HT receptor agonists, quipazine [4774-24-7], TFMPP (I) [15532-75-9], Org 10155 (II) [81078-82-2], Ru 24969 [66611-26-5], 5-methoxytryptamine [608-07-1], and 5-methoxy-N,N-dimethyltryptamine (III) [1019-45-0], were quantified and tested for Ca dependency following i.v. administration to pithed normotensive rats. The pressor responses induced by 5-methoxytryptamine and III were not influenced by Ca2+ entry blockade with nifedipine. The piperazine derivs. quipazine, I, and II were full agonists, but the pressor responses to these agonists were sensitive to Ca2+ entry blockade. III and Ru 24969 were partial agonists. Within the present series of 5-HT receptor agonists, a restricted side chain flexibility may enhance the dependency of their pressor responses to extracellular Ca2+.