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CAS No.: | 60857-08-1 |
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Name: | 12-DEOXYPHORBOL 13-ACETATE |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C22H30O6 |
Molecular Weight: | 390.477 |
Synonyms: | 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one,9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-,[1aR-(1aa,1bb,4ab,7aa,7ba,8a,9aa)]-;12-Deoxyphorbol 13-acetate;13-O-Acetyl-12-deoxyphorbol;NSC 623310;SA 101A;Stillingia factorS7;5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one,9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-,(1aR,1bS,4aR,7aS,7bR,8R,9aS)-; |
Density: | 1.31 g/cm3 |
Melting Point: | 216-219℃ |
Boiling Point: | 550.5 ºC at 760 mmHg |
Flash Point: | 188.7 ºC |
Solubility: | Soluble in DMSO or 100% ethanol |
Appearance: | White to off-white powder. |
PSA: | 104.06000 |
LogP: | 1.53010 |
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IUPAC name: (1aR,1bS,4aR,7aS,7bR,8R,9aS)-4a,7b-Dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate
Molecular Weight: 390.47 [g/mol]
Molecular Formula: C22H30O6
XLogP3-AA: 0.7
H-Bond Donor: 3
H-Bond Acceptor: 6
Index of Refraction: 1.599
Molar Refractivity: 101.62 cm3
Molar Volume: 297.1 cm3
Surface Tension: 57.9 dyne/cm
Density: 1.31 g/cm3
Flash Point: 188.7 °C
Enthalpy of Vaporization: 95.47 kJ/mol
Boiling Point: 550.5 °C at 760 mmHg
Vapour Pressure: 2.06E-14 mmHg at 25 °C
Product Categories of Prostratin (CAS NO.60857-08-1): Chiral Reagents; Intermediates & Fine Chemicals; Pharmaceuticals; Protein Kinase Inhibitors and Activators
The antiviral activity of Prostratin (CAS NO.60857-08-1) was discovered during research on the traditional knowledge of Samoan healers by ethnobotanist Paul Alan Cox and a team at the U.S. National Cancer Institute. Samoan healers use the mamala tree to treat hepatitis. Research indicated that prostratin has potential to be useful in the treatment of HIV as it could flush viral reservoirs in latently infected CD4+ T-cells.
Prostratin (CAS NO.60857-08-1) is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans (Euphorbiaceae). Research indicated that prostratin has potential to be useful in the treatment of HIV as it flushes viral reservoirs in latently.
Prostratin (CAS NO.60857-08-1), its Synonyms are 6H-Cyclopropa(3,4)benz(1,2-e)azulen-6-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bR,8R,9aS)- ; 6H-Cyclopropa(3,4)benz(1,2-e)azulen-6-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,8alpha,9aalpha))- .