Detail of "609-67-6"

Reference

Electrochemical reactions

Electrochemical reactions. Part 19. Intermolecular radical substitution during the reduction of 2-halo-N-methylbenzanilides. Grimshaw, James; Haslett, Reginald J.; Trocha-Grimshaw, Jadwiga (Dep. Chem., Queen's Univ., Belfast, N. Ire.). J. Chem. Soc., Perkin Trans. 1, (22), 2448-55 (English) 1977. CODEN: JCPRB4. ISSN: 0300-922X. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 72, 25 Electrochem. redn. of 2-halo-N-methylbenzanilides gave N-methyl-N-phenylcarbamoylphenyl radicals which reacted by substitution to give phenanthridones and biphenylcarboxamides or were reduced further to the N-methylbenzanilide. The occurrence of the substitution process confirms the presence of Ph radical intermediates. The max. yield of intramol. substitution products is limited by the proportion of syn amide rotamer present at equil. When the halogen is Cl, intramol. trapping of the resulting Ph radical is an efficent process and only the anti amide rotamer forms the N-methylbenzanilide. When the halogen is Br or iodine a significant proportion of the Ph radical derived from the syn amide rotamer is also converted by further redn. and protonation into the N-methylbenzanilide. 609-67-6 which is the cas registry number of one of substances is just one of reagents here. Intramol. radical substitution leads to both phenanthridones and biphenyl-2-carboxamides when the aniline component of the N-methylbenzanilide does not carry an ortho substituent. When an ortho substituent is present on the aniline component, only the biphenyl-2-carboxamide is formed. These results are compared with the results from related reactions. .

Diastereo- and regioselective intramolecular Heck reaction of a-amino alcohol derivatives for the synthesis of enantiomerically pure isoquinolines and benzazepines at ambient and high pressure

Diastereo- and regioselective intramolecular Heck reaction of a-amino alcohol derivatives for the synthesis of enantiomerically pure isoquinolines and benzazepines at ambient and high pressure. Tietze, Lutz F.; Burkhardt, Olaf; Henrich, Marielouise (Institute Organic Chemistry, Georg-August University, Goettingen D-37077, Germany). Liebigs Annalen/Recueil, (7), 1407-1413 (English) 1997 Wiley-VCH. CODEN: LIARFV. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Alkylation and acylation of (E)-BocR1NCHRCH:CHMe [Boc = Me3CO2C; R = (R)-Et, (S)-CHMe2; R1 = H or R = (S)-Me, (R)-Et; R1 = Me], easily prepd. from a-amino alcs., with 2-halobenzyl or 2-halobenzoyl halides gives the corresponding N-benzyl and N-benzoyl amines. These compds. cyclize with excellent stereo- and regioselectivity to enantiomerically pure isoquinolines I [X = H2, R = (S)-Me, R1 = Me; X = O, R = (S)-Me or (R)-Et, R1 = Me; X = H2, R = (R)-Et or (S)-CHMe2, R1 = Boc] in an intramol.There are some reagents like 609-67-6 is used in this study. Heck reaction using 5 mol% of Pd(OAc)2 in the presence of PPh3, TPAB, and KOAc. Under the same conditions, pyrrolidine II leads to the enantiomerically pure benzazepine III. The reaction of the bromoarenes (E)-2-BrC6H4CH2BocNCHRCH:CHMe [R = (R)-Et, (S)-CHMe2] must be performed under high pressure to give good results. .