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| CAS No.: | 609-71-2 |
|---|---|
| Name: | 2-Hydroxynicotinic acid |
| Article Data: | 47 |
| Molecular Structure: | |
|
|
|
| Formula: | C6H5NO3 |
| Molecular Weight: | 139.111 |
| Synonyms: | 1,2-Dihydro-2-oxonicotinic acid;2-Hydroxy-3-pyridinecarboxylic acid;2-Hydroxy-3-Pyridine Carboxylic acid;2-oxo-1H-pyridine-3-carboxylic acid;2-oxo-1H-pyridine-3-carboxylate;1,2-Dihydro-2-oxo-3-pyridinecarboxylic acid; |
| EINECS: | 210-198-2 |
| Density: | 1.451 g/cm3 |
| Melting Point: | 258-261 °C(lit.) |
| Boiling Point: | 436 °C at 760 mmHg |
| Flash Point: | 217.5 °C |
| Appearance: | white to light yellow powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36-37/39 |
| PSA: | 70.42000 |
| LogP: | 0.48540 |
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| Conditions | Yield |
|---|---|
| With hydrogenchloride; water for 6h; Heating; | 92% |
| With copper(I) oxide; 2-pyridinealdoxime; cesium hydroxide; tetrabutylammomium bromide In water at 110℃; for 48h; Inert atmosphere; | 63% |
| Heating; | |
| With sodium hydroxide In ethanol; water |
| Conditions | Yield |
|---|---|
| Stage #1: 3-bromo-pyridin-2-ol With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.5h; Stage #3: carbon dioxide In tetrahydrofuran; hexane at -20℃; for 0.5h; | 79% |
- 2398-81-4
Nicotinic acid N-oxide
- 108-24-7
acetic anhydride
A
- 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid
B
- 609-71-2
2-hydroxy-3-carboxypyridine
C
- 111068-01-0
3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide
| Conditions | Yield |
|---|---|
| for 6h; Heating; | A 1.5% B 5.4% C 62% |
- 2398-81-4
Nicotinic acid N-oxide
A
- 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid
B
- 609-71-2
2-hydroxy-3-carboxypyridine
C
- 111068-01-0
3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide
| Conditions | Yield |
|---|---|
| With acetic anhydride for 6h; Heating; | A 1.5% B 5.4% C 62% |
- 2942-59-8
2-chloronicotinic acid
A
- 609-71-2
2-hydroxy-3-carboxypyridine
B
- 5345-47-1
2-aminopyridin-3-carboxylic acid
| Conditions | Yield |
|---|---|
| With ammonium hydroxide at 155℃; for 20h; | A n/a B 60% |
- 83164-33-4
N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)-3-pyridinecarboxamide
A
- 609-71-2
2-hydroxy-3-carboxypyridine
B
- 98-17-9
3-Trifluoromethylphenol
C
- 367-25-9
2,4-difluorophenylamine
D
- 130191-66-1
N-(2,4-Difluorophenyl)-2-hydroxy-3-pyridinecarboxamide
| Conditions | Yield |
|---|---|
| With hydrogenchloride; acetic acid In water for 48h; Heating; | A 57% B n/a C n/a D 28% |
| With hydrogenchloride; acetic acid In water for 48h; Product distribution; Mechanism; Heating; | A 57% B n/a C n/a D 28% |
- 2398-81-4
Nicotinic acid N-oxide
- 123-62-6
propionic acid anhydride
A
- 609-71-2
2-hydroxy-3-carboxypyridine
C
- 115147-79-0
5-aza-3-methyl-4-propionyloxyisocoumarin
| Conditions | Yield |
|---|---|
| at 125℃; for 6h; | A n/a B n/a C 12.9% D 54.2% |
- 2398-81-4
Nicotinic acid N-oxide
- 123-62-6
propionic acid anhydride
A
- 609-71-2
2-hydroxy-3-carboxypyridine
C
- 115147-79-0
5-aza-3-methyl-4-propionyloxyisocoumarin
D
- 115147-80-3
4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone
| Conditions | Yield |
|---|---|
| at 160℃; for 4h; Yield given. Further byproducts given; | A n/a B n/a C 39.8% D 16.4% |
- 2398-81-4
Nicotinic acid N-oxide
- 123-62-6
propionic acid anhydride
A
- 609-71-2
2-hydroxy-3-carboxypyridine
C
- 115147-79-0
5-aza-3-methyl-4-propionyloxyisocoumarin
D
- 115147-80-3
4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone
F
- 115147-81-4
4-aza-3-ethyl-3,5-dipropionyloxy-1(3H)-isobenzofuranone
| Conditions | Yield |
|---|---|
| at 160℃; for 4h; Product distribution; Mechanism; various temperatures and times; | A n/a B n/a C 39.8% D 16.4% E 8.3% F 2.1% |
- 504-29-0
2-aminopyridine
- 2942-59-8
2-chloronicotinic acid
A
- 609-71-2
2-hydroxy-3-carboxypyridine
B
- 99973-09-8
2-hydroxy-nicotinic acid-[2]pyridylamide
C
- 109255-91-6
2-(2-hydroxy-nicotinoylimino)-2H-[1,2']bipyridyl-3'-carboxylic acid
| Conditions | Yield |
|---|---|
| at 180 - 185℃; |
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Chemistry
Molecular Structure of 2-Hydroxynicotinic acid (CAS NO. 609-71-2):
IUPAC Name: 2-Oxo-1H-pyridine-3-carboxylic acid
Molecular Formula: C6H5NO3
Molecular Weight: 139.108800 g/mol
Index of Refraction: 1.579
Molar Refractivity: 31.84 cm3
Molar Volume: 95.8 cm3
Surface Tension: 61 dyne/cm
Density: 1.451 g/cm3
Flash Point: 217.5 °C
Enthalpy of Vaporization: 75.92 kJ/mol
Boiling Point: 436 °C at 760 mmHg
Vapour Pressure: 8.03E-09 mmHg at 25 °C
Melting Point: 258-261 °C(lit.)
BRN: 119028
EINECS: 210-198-2
Product Categories: blocks;Carboxes;Pyridines;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Organic acids;CHIRAL CHEMICALS
Safety Profile
Safety Information of 2-Hydroxynicotinic acid (CAS NO. 609-71-2):
Hazard Codes: Xi 
Hazard Note: Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36:Wear suitable protective clothing
S37/39:Wear suitable gloves and eye/face protection
WGK Germany: 3
HazardClass: IRRITANT
Specification
2-Hydroxynicotinic acid with cas registry number of 609-71-2 is also called NSC 226152 ; 1,2-Dihydro-2-oxo-3-pyridinecarboxylic acid ; 1,2-Dihydro-2-oxonicotinic acid .