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| CAS No.: | 61-00-7 |
|---|---|
| Name: | acepromazine |
| Article Data: | 13 |
| Molecular Structure: | |
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| Formula: | C19H22 N2 O S |
| Molecular Weight: | 326.462 |
| Synonyms: | Ketone,10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl (8CI);10-(3-Dimethylaminopropyl)phenothiazin-3-yl methyl ketone; 1522CB;2-Acetylpromazine; 3-Acetyl-10-(3-dimethylaminopropyl)phenothiazine;Acepromazin; Acepromazine; Acetacin; Acetazin; Acetazine; Acetopromazine;Acetylpromazine; Azepromazine; CC 64; Placivet; Plegicil; Plivafen; Vetranquil |
| Density: | 1.1075 (rough estimate) |
| Melting Point: | <25 °C |
| Boiling Point: | bp0.5 220-240° |
| Solubility: | 16mg/L(25 oC) |
| Safety: | Poison by ingestion, intravenous, and subcutaneous routes. A flammable liquid. When heated to decomposition it emits toxic fumes of SOx and NOx. See also KETONES. An animal tranquilizer. |
| PSA: | 48.85000 |
| LogP: | 4.50860 |
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| Conditions | Yield |
|---|---|
| With copper(l) iodide; potassium carbonate; L-proline In ethyl methyl ether at 90 - 110℃; Inert atmosphere; | 75% |
| Conditions | Yield |
|---|---|
| Stage #1: 2-acetylphenothiazine With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 3-(Dimethylamino)propyl chloride In N,N-dimethyl-formamide at 50℃; for 5h; | 22% |
| With sodium hydride |
- 59995-97-0
2-acetyl-phenothiazine-10-carboxylic acid 3-dimethylamino-propyl ester
- 61-00-7
acetopromazine
| Conditions | Yield |
|---|---|
| oder unter vermindertem Druck; | |
| With copper; 1,3-Dimethoxybenzene |
- 39481-55-5
2-acetyl-10-(3'-chloropropyl)-10H-phenothiazine
- 124-40-3
dimethyl amine
- 61-00-7
acetopromazine
| Conditions | Yield |
|---|---|
| In ethanol |
| Conditions | Yield |
|---|---|
| Stage #1: 2-chloro-benzaldehyde; acetopromazine With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7; | 81% |
| Conditions | Yield |
|---|---|
| Stage #1: 4-chlorobenzaldehyde; acetopromazine With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7; | 78% |
| Conditions | Yield |
|---|---|
| Stage #1: acetopromazine; benzaldehyde With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7; | 68% |
| Conditions | Yield |
|---|---|
| Stage #1: acetopromazine; 2,4-dichlorobenzaldeyhde With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7; | 62% |
| Conditions | Yield |
|---|---|
| Stage #1: 2-Trifluoromethylbenzaldehyde; acetopromazine With sodium ethanolate In ethanol Cooling with ice; Sonication; Stage #2: With hydrogenchloride pH=5 - 7; | 58% |
- Total:28 Page 1 of 1 1
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Chemistry
Molecular Structure of Acetopromazine (CAS NO.61-00-7):
IUPAC Name: 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
Empirical Formula: C19H22N2OS
Molecular Weight: 326.4558
Index of Refraction: 1.609
Surface Tension: 45.4 dyne/cm
Density: 1.155 g/cm3
Flash Point: 254.4 °C
Enthalpy of Vaporization: 76.49 kJ/mol
Boiling Point: 497 °C at 760 mmHg
Vapour Pressure: 5.13E-10 mmHg at 25°C
Synonyms of Acetopromazine (CAS NO.61-00-7): acepromazine ; 10-[3-[Dimethylamino] propyl] phenothiazin-2-yl methyl ketone ; Acetylpromazine;Ethanone, 1-10-3-(dimethylamino)propyl-10H-phenothiazin-2-yl-;KETONEketone,10-(3-(dimethylamino)propyl)phenothiazin-2-ylmethyl ; 10-(3-dimethylaminopropyl)phenothiazine-3ethylone ; Acepromazine (base and/or unspecified salts) ; 1-[10-(3-dimethylaminopropyl)phenothiazin-2-yl]ethanone
Toxicity Data With Reference
| 1. | ipr-rat LD50:140 mg/kg | FATOAO Farmakologiya i Toksikologiya (Moscow). 24 (1961),136. | ||
| 2. | orl-mus LDLo:200 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 113 (1957),53. | ||
| 3. | ipr-mus LD50:350 mg/kg | RMNIBN Revista Medico-Chirurgicala. 81 (1977),105. | ||
| 4. | scu-mus LD50:130 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 113 (1957),53. | ||
| 5. | ivn-mus LD50:59 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 115 (1958),1. |
Safety Profile
Poison by ingestion, intravenous, and subcutaneous routes. A flammable liquid. When heated to decomposition it emits toxic fumes of SOx and NOx. See also KETONES. An animal tranquilizer.
Standards and Recommendations
DOT Classification: 3; Label: Flammable Liquid
Specification
Acetopromazine (CAS NO.61-00-7) is an orange yellow oily liquid. Boiling point is 220-240 ℃ (66.5Pa),its maleate yellow crystal, melting point is 135-136 ℃, soluble in water, 0.1% of the aqueous solution pH is 5.2, no foul and bitter taste, flammable,thermal decomposition would release toxic fumes of nitrogen oxides and sulfur oxides,it should be stored in low temperature, ventilation, drying environmental conditions,separated with food and raw materials, besides water, carbon oxides and oxidation of toxic carbon dioxide, dry powder, sand, water mist fire extinguishing agent can be used if emergency.
Its use is similar with chlorpromazine , but stable activity is weaker than chlorpromazine , poorer treatment outcomes. Used for sedation, anti-psychotic, antiemetic, analgesic and anti-convulsive and so on. And analgesics, hypnotics, local anesthetics such as in combination can strengthen its role. Be connection with pethidine, promethazine combination agent for the artificial hibernation.