Detail of "61-94-9"

Reference

Antagonism by cholinergic drugs of behavioral effects in cats of an anticholinergic psychotomimetic drug and enhancement by nicotine

Antagonism by cholinergic drugs of behavioral effects in cats of an anticholinergic psychotomimetic drug and enhancement by nicotine. Lowy, K.; Abood, M. E.; Drexler, M.; Abood, L. G. (Med. Cent., Univ. Rochester, Rochester, N. Y., USA). Neuropharmacology, 16(6), 399-403 (English) 1977. CODEN: NEPHBW. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) N-methyl-4-piperidylisopentynylphenyl glycollate (I) [16862-13-8] (10-25 .mu.g/kg, s.c.) modified the no. of responses and the lateral preference for the use of left or right levers of cats trained to press a lever for a food reward in response to an auditory stimulus. Administration of physostigmine-HCl [6091-12-9] (50 .mu.g/kg, s.c.) or 1,2,3,4-tetrahydroaminoacridine-HCl [1684-40-8] (100 .mu.g/kg, s.c.) with I caused both parameters to return to normal. Arecoline-HCl [61-94-9] (100 .mu.g/kg, s.c.) had a slight antagonistic effect, while nicotine-HCl [2820-51-1] (100 .mu.g/kg, s.c.) enhanced the effect of I. The behavioral effects of I must involve muscarinic neurons.

Specificity of arecoline and apomorphine and the site of action of arecoline in inhibiting the diurnal prolactin surge

Specificity of arecoline and apomorphine and the site of action of arecoline in inhibiting the diurnal prolactin surge. Subramanian, Marappa G.; Gala, Richard R. (Dep. Physiol., Wayne State Univ. Sch. Med., Detroit, Mich., USA). Proc. Soc. Exp. Biol. Med., 155(3), 353-6 (English) 1977. CODEN: PSEBAA. ISSN: 0037-9727. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 13 Ovariectomized, polyestradiol phosphate (PEP-injected, catheterized rats exhibiting a daily diurnal plasma prolactin [9002-62-4] surge were used to investigate the specificity of cholinergic receptor blocker drugs and to demonstrate the presence of cholinergic receptors outside the blood-brain barrier. Atropine methylnitrate (AMN) [52-88-0] blocked the inhibitor effect of arecoline-HCl (I) [61-94-9] on the diurnal surge of plasma prolactin and this blockade was more dramatic for the later time periods. The tremorogenic effect of I (a CNS action) was not blocked, whereas the salivation effect of I (a peripheral action) was blocked by AMN. The prolactin and behavioral responses were taken to indicate that AMN does not pass the blood-brain barrier and that there are cholinergic receptors inhibiting prolactin release outside this barrier, perhaps directly on the pituitary. Mecamylamine-HCl [826-39-1], a nicotine blocker, did not have any effect either on the I-induced blockade of the prolactin surge or on the I-induced behavioral responses. Atropine sulfate (AS) [55-48-1], a muscarinic blocker, did not influence either the apomorphine-HCl (II-HCl) [314-19-2]-induced inhibitions of the prolactin surge or the II-induced behavioral responses.