Reference

Antibacterial activities of phenolic benzaldehydes and benzoic acids against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica

Friedman, Mendel; Henika, Philip R.; Mandrell, Robert E.Some chemicals with cas registry numbers like 610-02-6 and 121-34-6 are also used. (Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA 94710, USA). Journal of Food Protection, 66(10), 1811-1821 (English) 2003 International Association for Food Protection. CODEN: JFPRDR. ISSN: 0362-028X. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) We evaluated the bactericidal activities of 35 benzaldehydes, 34 benzoic acids, and 1 benzoic acid Me ester against Campylobacter jejuni, Escherichia coli O157:H7, Listeria monocytogenes, and Salmonella enterica when these compds. were substituted on the benzene ring-with 0, 1, 2, or 3 hydroxy (OH) and/or methoxy (OCH3) groups in a pH 7.0 buffer. Dose-response plots were used to det. the percentage of the sample that induced a 50% decrease in CFU after 60 min (BA50). Of the 70 compds. tested, 24 were found to be active against all four pathogens, and addnl. 4, 10, and 12 were found to be active against three, two, and one of the pathogens, resp. C. jejuni was ~100 times as sensitive as the other three pathogens. The 10 compds. that were most active against the four pathogens (with av. BA50 values ranging from 0.026 to 0.166) and are candidates for studies of activity in foods or for disinfections were 2,4,6-trihydroxybenzaldehyde, 2,5-dihydroxybenzaldehyde, 2,3,4-trihydroxybenzaldehyde, 2-hydroxy-5-methoxybenzaldehyde, 2,3-dihydroxybenzaldehyde, 2-hydroxy-3-methoxybenzaldehyde, 4-hydroxy-2,6-dimethoxybenzaldehyde, 2,5-dihydroxybenzaldehyde, 2,4-dihydroxybenzaldehyde, and 2-hydroxybenzaldehyde. Comparison of the chem. structures of the test compds. and their activities revealed that (i) the aldehyde (CHO) group was more active than the carboxyl (COOH) group whether or not OH groups were present; (ii) compds. were most active with trisubstituted OH > disubstituted OH > monosubstituted OH; (iii) for disubstituted derivs., 2-OH enhanced activities were exhibited by benzaldehyde but not by benzoic acid; (iv) compds. were more active with OH than with OCH3, irresp. of the position of substitution on the benzene ring; (v) compds. with mixed OH and OCH3 groups exhibited variable results, i.e., in some cases OCH3 groups enhanced activity and in other cases they did not; (vi) methoxybenzoic acids were largely inactive; and (vii) gallic acid was 20 times as active against S. enterica at pH 7.0 as it was at pH 3.7, suggesting that the ionization of its OH groups may enhance bactericidal activity. .

Heteroligand complexes of neodymium, holmium, and erbium ions with ethylenediaminetetraacetic acid and gallic or pyrogallolcarboxyl acids

Heteroligand complexes of neodymium, holmium, and erbium ions with ethylenediaminetetraacetic acid and gallic or pyrogallolcarboxyl acids. Tishchenko, M. A.; Zheltvai, I. I. 7440-52-0 and 610-02-6 are also occured in this study.; Poluektov, N. S. (Inst. Zagal'noi Neorg. Khim., Odessa, USSR). Dopov. Akad. Nauk Ukr, RSR, Ser. B: Geol., Khim. Biol. Nauki, (10), 917-19 (Ukrainian) 1976. CODEN: DANND6. DOCUMENT TYPE: Journal CA Section: 78 (Inorganic Chemicals and Reactions) Section cross-reference(s): 73, 68 Absorption spectra of complexes formed at pH >8 in solns. contg. 0.01M M(III) (M = Nd, Ho, and Er), 0.01M ethylenediaminetetraacetate (I), and variable concns. of gallic or pyrogallolcarboxylic acid (II and III, resp.) were measured and the formation of complexes with a M:I (II or III) ratio of 1:1:1 was indicated. II and III are coordinated to M through the O atoms of 2 OH groups. The coordination of a II ion to M(H2O)63+ causes a larger increase of the oscillator strength than the coordination to the M3+ ion bound in a M(III)-I complex. .